Systemic lupus erythematosus and thyroid disease: A 10-year study

Lin, Wen-Ya; Chang, Chia-Li; Fu, Lin-Shien; Lin, Ching-Heng; Lin, Heng-Kuei

doi:10.1016/j.jmii.2014.03.004

Cited by 37 publications

(44 citation statements)

References 22 publications

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“…However, discordant results have been recently reported (33). In 1,633 SLE patients of new diagnosis, the prevalence of hyperthyroidism, hypothyroidism, and autoimmune thyroiditis (AT) was compared with 6,532 controls (matched by sex and age).…”

Section: The Association Of Sle and Aitdmentioning

confidence: 64%

“…The authors suggested that SLE patients had a significantly lower rate of thyroid diseases and hyperthyroidism than matched controls (33). The reported study could have some limitations, able to affect the results, to be considered: (1) it was based on diagnostic codes released from The National Health Insurance Research Database, and for this reason details on thyroid serological assessments, presence of ThyAb, or SLE autoantibodies were not available; (2) data obtained in a retrospective cohort study are usually inferior in statistical quality to those derived from randomized trials because of the potential biases related to adjustments for confounding variables (33). A total of 376 Colombian SLE patients were evaluated for the presence of (1) confirmed autoimmune hypothyroidism (AH), (2) positive AbTPO/AbTg without hypothyroidism, (3) non-AH, and (4) SLE patients with neither.…”

Section: The Association Of Sle and Aitdmentioning

confidence: 99%

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Systemic Lupus Erythematosus and Thyroid Autoimmunity

et al. 2017

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Most of the studies present in the literature show a high prevalence, and incidence, of new cases of hypothyroidism and autoimmune thyroiditis (AT) in systemic lupus erythematosus (SLE) patients, overall in female gender. A limited number of cases of Graves’ disease have been also reported in SLE patients, in agreement with the higher prevalence of thyroid autoimmunity. It has been also demonstrated that a Th1 predominance is associated with AT in SLE patients. Furthermore, a higher prevalence of papillary thyroid cancer has been recently reported in SLE, in particular in the presence of thyroid autoimmunity. However, studies in larger number of SLE patients are needed to confirm findings about thyroid cancer. On the whole, data from literature strongly suggest that female SLE patients, with a high risk (a normal but at the higher limit thyroid-stimulating hormone value, positive antithyroid peroxidase antibodies, a hypoechoic pattern, and small thyroid), should undergo periodic thyroid function follow-up, and appropriate treatments when needed. A careful thyroid monitoring would be opportune during the follow-up of these patients.

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Section: The Association Of Sle and Aitdmentioning

confidence: 64%

Section: The Association Of Sle and Aitdmentioning

confidence: 99%

Systemic Lupus Erythematosus and Thyroid Autoimmunity

et al. 2017

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“…Even though more recent studies have investigated the relationship between thyroid disease and SLE using data from large populations, they also provide inconsistent and conflicting results. A Taiwanese retrospective nationwide cohort study showed that SLE patients had a significantly lower rate of thyroid disease [15], whereas another recent study in Israel reported that both hyper- and hypothyroidism were associated with SLE [13, 16]. …”

Section: Introductionmentioning

confidence: 99%

Increased risk of thyroid diseases in patients with systemic lupus erythematosus: A nationwide population-based Study in Korea

et al. 2017

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We investigated the association between autoimmune thyroid disease and systemic lupus erythematosus (SLE) using nationwide insurance claims data for the entire Korean population. Claims data for the period 2009–2013 were retrieved from the National Health Insurance System database. SLE and thyroid disease were identified using the International Classification of Diseases codes and medication information. Logistic regression analyses were used to evaluate the association between SLE and thyroid disease. The study used records from 17,495 patients with SLE and 52,485 age- and sex-matched control subjects. A greater prevalence of Graves’ disease (0.94% vs. 0.46%, P < 0.001), Hashimoto’s thyroiditis (2.68% vs. 0.80%, P < 0.001), and thyroid cancer (1.81% vs. 1.30%, P < 0.001) was observed in SLE patients than in control subjects. Multivariate regression analyses demonstrated that SLE was significantly associated with an increased risk of both autoimmune thyroid disease and thyroid cancer (Graves’ disease: odds ratio [OR] 2.07, 95% confidence interval [CI] 1.70–2.53; Hashimoto’s thyroiditis: OR 3.42, 95% CI 3.00–3.91; thyroid cancer: OR 1.40, 95% CI 1.22–1.60). Age- and sex- stratified analyses revealed that the risk of autoimmune thyroid disease in SLE patients was increased for all age groups and the female group. An association between thyroid cancer and SLE was identified only in the 20- to 59-year-old age group and in the female group. Using a large population-based study, we demonstrated that patients with SLE are at a greater risk of developing thyroid disease than matched control individuals.

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“…Clustering of multiple autoimmune disorders has been described as a spectrum ranging from involving one organ (such as autoimmune thyroiditis and CLE) to involving multiple organs 15. However, an extensive PubMed search revealed no association between DSH and autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

Dyschromatosis symmetrica hereditaria with cutaneous lupus erythematosus and hyperthyroidism

Alsaif¹,

Alhumidi²,

Alhallaf³

2017

IMCRJ

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Dyschromatosis symmetrica hereditaria (DSH) is a rare genodermatosis characterized by various sizes of both hyper- and hypopigmented macules arranged in reticulated patterns on the face and the dorsal aspects of the extremities. There are also cutaneous and extracutaneous abnormalities, but they are rare. As far as we know, DSH associated with immune-mediated conditions has not been reported. We report the first case of DSH, which is associated with cutaneous lupus erythematosus and hyperthyroidism.

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Systemic lupus erythematosus and thyroid disease: A 10-year study

Abstract: SLE patients had a significantly lower rate of thyroid diseases and hyperthyroidism than matched controls. Among SLE patients, risks of hypothyroidism and autoimmune thyroiditis were different in the presence of overlap syndrome. This finding is novel and important for clinical practices.

Cited by 37 publications

References 22 publications

Systemic Lupus Erythematosus and Thyroid Autoimmunity

Systemic Lupus Erythematosus and Thyroid Autoimmunity

Increased risk of thyroid diseases in patients with systemic lupus erythematosus: A nationwide population-based Study in Korea

Dyschromatosis symmetrica hereditaria with cutaneous lupus erythematosus and hyperthyroidism

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