Systemic lupus erythematosus-associated lymphoproliferative disorder: Report of a case and discussion in light of the literature

Blanco, Ramon; McLaren, Bernadette K.; Davis, Betty; Steele, Paul; Smith, R. Neal

doi:10.1016/s0046-8177(97)90015-0

Cited by 26 publications

(28 citation statements)

References 23 publications

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“…Histologically, the present 9 cases were characterized by : (i) prominent lymphoplasmacytic and B-immunoblastic infiltration ; (ii) an absence of pronounced arborizing vascular proliferation ; (iii) absence of CD10 + "clear cells" ; (iv) presence of hyperplastic germinal center in 7 cases ; (v) a polyclonal nature of both T-and B-lymphocytes on immunophenotypic and genotypic analysis ; (vi) flowcytometry demonstrated that there was no absence of pan T-cell marker, which is a characteristic flowcytometric finding of AITL ; 18 and (vii) EBV-infected lymphoid cells were absent in all 9 cases. The overall histologic, immunohistochemical, genotypic, and EBV findings of this case were similar to those of previous reports, [3][4][5][6][7] and the present 9 cases may be classified as ALPIB associated with AIDs.…”

Section: Discussionsupporting

confidence: 90%

“…As previously suggested by Blanco et al, 4 the absence of EBV as determined by ISH studies in all our 9 cases indicates that EBV was not related to the lymphoproliferative process in the majority of ALPIB cases. Moreover, the present study suggests that the underlying cause of lymphadenopathy in these ALPIB patients may involve the chronic immune problems caused by AID.…”

supporting

confidence: 87%

“…Lymphoid follicles were seen in 7 cases (nos. [3][4][5][6][7][8][9], and their germinal centers were usually hyperplastic, although a few were rather atrophic. Each case contained mild to moderate small vessels in the interfollicular area.…”

Section: Pathological Immunohistochemical and Ebv Findingsmentioning

confidence: 99%

“…However, except for an earlier report by Koo et al, 3 only sporadic case reports have been published. [4][5][6][7] Previously, we reported clinicopathologic findings of 5 such cases. [5][6][7] Recently, several authors have emphasized the differential diagnostic problems for ALPIB from lymph node lesions of IgG4-related diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Multicentric lymph node enlargement was present in 6 cases (nos. [4][5][6][7][8][9]. Analysis of patient lifestyles did not suggest any risk factors for human immunodeficiency virus type-1 infection, although serological data on anti-human immunodeficiency virus type-1 antibody were available in only 4 cases (nos.…”

mentioning

confidence: 99%

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Atypical Lymphoplasmacytic and Immunoblastic Proliferation of Autoimmune Disease : Clinicopathologic and Immunohistochemical Study of 9 Cases

Kojima

Nakamura

Tsukamoto

et al. 2010

J Clin Exp Hematopathol

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Atypical lymphoplasmacytic immunoblastic proliferation (ALPIB) is a rare lymphoproliferative disorder (LPD) associated with autoimmune disease (AID). To further clarify the clinicopathologic, immunohistological, and genotypic findings of ALPIB in lymph nodes associated with well-documented AIDs, 9 cases are presented. These 9 patients consisted of 4 patients with systemic lupus erythematosus, 3 patients with rheumatoid arthritis, and one case each with Sjögren's syndrome and dermatomyositis. All 9 patients were females aged from 25 to 71 years with a median age of 49 years. Four cases presented with lymphadenopathy as the initial manifestation. In 4 patients, immunosuppressive drugs were administered before the onset of lymph node lesion. However, none of the 9 patients received methotrexate therapy. The present 9 cases were characterized by : (i) prominent lymphoplasmacytic and B-immunoblastic infiltration ; (ii) absence of pronounced arborizing vascular proliferation ; (iii) absence of CD10 + "clear cells" ; (iv) presence of hyperplastic germinal center in 7 cases ; (v) immunohistochemistry, flow cytometry, and polymerase chain reaction demonstrated a reactive nature of the T-and B-lymphocytes ; and (vi) on in situ hybridization, there were no Epstein-Barr virus -infected lymphoid cells in any of the 9 cases. Overall 5-year survival of our patients was 83%. The combination of clinical, immunophenotypic, and genotypic findings indicated that the present 9 cases can be regarded as having an essentially benign reactive process. Finally, we emphasized that ALPIB should be added to the differential diagnostic problems of atypical LPDs, particularly lymph node lesions of IgG4-related diseases. 〔J Clin Exp Hematopathol 50(2) : 113-119, 2010〕

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Section: Discussionsupporting

confidence: 90%

supporting

confidence: 87%

Section: Pathological Immunohistochemical and Ebv Findingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Atypical Lymphoplasmacytic and Immunoblastic Proliferation of Autoimmune Disease : Clinicopathologic and Immunohistochemical Study of 9 Cases

Kojima

Nakamura

Tsukamoto

et al. 2010

J Clin Exp Hematopathol

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Chronische Gelenkentzündungen

Mohr¹

2000

Gelenkpathologie

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Systemic Lupus Erythematosus Associated Pitfalls on 18F-FDG PET/CT: Reactive Follicular Hyperplasia, Kikuchi-Fujimoto Disease, Inflammation and Lymphoid Hyperplasia of the Spleen Mimicking Lymphoma

Makis¹,

Ciarallo²,

Gonzalez-Verdecia³

et al. 2017

Nucl Med Mol Imaging

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Systemic lupus erythematosus (SLE) is associated with a variety of inflammatory processes that can affect the lymph nodes, brain, kidneys, and spleen. We present two patients with SLE in whom SLE-associated conditions complicated interpretation of F-fluoro-2-deoxy-d-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT) imaging of the lymph nodes and the spleen. The imaging findings mimicked lymphoma, but histopathological evaluation showed benign processes including reactive follicular hyperplasia in the lymph nodes, Kikuchi-Fujimoto disease in perisplenic lymph nodes, and inflammatory changes and lymphoid hyperplasia in the spleen.

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Systemic lupus erythematosus-associated lymphoproliferative disorder: Report of a case and discussion in light of the literature

Cited by 26 publications

References 23 publications

Atypical Lymphoplasmacytic and Immunoblastic Proliferation of Autoimmune Disease : Clinicopathologic and Immunohistochemical Study of 9 Cases

Atypical Lymphoplasmacytic and Immunoblastic Proliferation of Autoimmune Disease : Clinicopathologic and Immunohistochemical Study of 9 Cases

Chronische Gelenkentzündungen

Systemic Lupus Erythematosus Associated Pitfalls on 18F-FDG PET/CT: Reactive Follicular Hyperplasia, Kikuchi-Fujimoto Disease, Inflammation and Lymphoid Hyperplasia of the Spleen Mimicking Lymphoma

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