Systemic Lupus Erythematosus in Domestic Animals

Day, Michael

doi:10.1016/b978-0-12-374994-9.10025-7

Cited by 3 publications

(3 citation statements)

References 79 publications

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“…Several studies have attempted to correlate the activity of specific antibodies with patterns of nuclear labeling. Early studies had shown that anti-T1 (hnRNP G) gives a relatively fine speckle pattern, anti-Sm and anti-RNP give a coarser speckle or reticulum nodule pattern, and anti-histone antibody gives a generally homogeneous pattern [18].…”

Section: Discussionmentioning

confidence: 99%

Detection of Antinuclear Antibodies in Canine Serum by Immunoperoxidase in MDCK and Indirect Immunofluorescence in HEp2 Cells

Anda¹,

Lara²,

Uribe³

et al. 2023

OJVM

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Antinuclear antibodies are found in animals suffering from Systemic Lupus Erythematosus (SLE) and some other diseases, their presence in the blood is determined by antinuclear antibody (ANA) test using indirect immunofluorescence (IF) with HEp2 cells as a substrate. In this work, an immunoperoxidase (IP) assay was developed to evaluate the ANAs in canine sera, using canine kidney cell lines (MDCK) and compared with a commercial immunofluorescence test on Hep2 cells for this system, a fluoresceinated anti-canine Ig antibody was standardized. The study was performed on 50 sera from dogs submitted to the laboratory with different clinical diagnoses of autoimmuneassociated diseases. The procedures on both cells were unified to perform comparisons of the reactions, direct sera or at different dilutions were added to a monolayer of permeabilized MDCK cells, followed by a peroxidized anti-canine IgG conjugate, and a substrate for the IP reaction. The same sera were tested on the commercial IF assay on Hep2 cell system. In 22/50 cases, the presence of LE cells in peripheral blood was determined. A high correlation was found in the detection of antinuclear antibodies between both cell lines and techniques, however there were differences in the reaction patterns in the nucleus and cytoplasm between cell lines. The diffuse nuclear pattern observed in MDCK cells was more related to the presence of high percentages of LE cells in peripheral blood. The differences found in the results were possibly associated with the presence of homologous antigens between the MDCK cells and the dog. In addition, the methodology and standardization for the use and interpretation of a reference serum was developed to unify the interpretation criteria in the laboratory.

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Section: Discussionmentioning

confidence: 99%

Detection of Antinuclear Antibodies in Canine Serum by Immunoperoxidase in MDCK and Indirect Immunofluorescence in HEp2 Cells

Anda¹,

Lara²,

Uribe³

et al. 2023

OJVM

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“…Gran parte del conocimiento acerca de la patogenia del LE proviene de estudios en roedores. Además de estar presente en humanos, el LE ha sido reconocido en perros, gatos, caballos, y se han reportados casos de "LESlike" en serpientes e iguanas 5 . El lupus cutáneo canino es una enfermedad que se presenta con hipomelanosis, eritema, descamación y pérdida erosiva de la arquitectura normal del plano nasal.…”

Section: Sr Editorunclassified

Lupus eritematoso cutáneo canino: algunas consideraciones acerca de la cercanía humana con los animales

Lecaros-Cornejo

Dı́az

2015

Rev. méd. Chile

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“…Superficial necrolytic dermatitis, zinc‐responsive dermatitis and systemic lupus erythematosus could not be completely excluded as potential causes of the pedal hyperkeratosis and other dermatological changes. It was decided to postpone tests to investigate these disorders until stabilisation of the DM and hypothyroidism could be achieved. Progression of dermatological changes was monitored during that time.…”

Section: Case Reportmentioning

confidence: 99%

Hypothyroidism associated with acromegaly and insulin‐resistant diabetes mellitus in aSamoyed

2014

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To the authors' knowledge, this is the first reported case that suggests that GH alterations may have clinical significance in naturally occurring hypothyroidism. Among other factors, hypothyroidism-induced GH excess should be considered as a possible cause of IR in patients suffering from hypothyroidism and concurrent DM. In such cases, DM may reverse with treatment of hypothyroidism, as was documented in this case.

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Systemic Lupus Erythematosus in Domestic Animals

Cited by 3 publications

References 79 publications

Detection of Antinuclear Antibodies in Canine Serum by Immunoperoxidase in MDCK and Indirect Immunofluorescence in HEp2 Cells

Detection of Antinuclear Antibodies in Canine Serum by Immunoperoxidase in MDCK and Indirect Immunofluorescence in HEp2 Cells

Lupus eritematoso cutáneo canino: algunas consideraciones acerca de la cercanía humana con los animales

Hypothyroidism associated with acromegaly and insulin‐resistant diabetes mellitus in aSamoyed

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