Systemic lupus erythematosus in Saudi patients

Al-Balla, Suliman R.

doi:10.1007/bf02208351

Cited by 45 publications

(52 citation statements)

References 28 publications

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“…In our study, overall consanguinity rate between patients' parents was high in both familial and sporadic group (61.5% vs. 58.8%; Table 3). These results could suggest that consanguinity may be the cause of higher prevalence of SLE in Saudi Arabia compared with developed countries [3]. In one study from Kuwaiti population [14], which is also considered highly consanguineous, the prevalence of familial SLE was 27.4%, which is almost identical to our results (27.7%; Table 2).…”

Section: Discussionsupporting

confidence: 88%

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Familial Lupus and Clinical Characteristics in Saudi Arabia

Albishri¹,

Alshehri²,

Altowairqi³

et al. 2015

IJCM

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Background: It has been proven that a family history of systemic lupus erythematosus (SLE) is a risk factor for the development of the disease, and the risk increases with increasing number of relatives affected. In Saudi Arabia, high consanguinity rate leads to higher incidence of familial form than in other countries. We compare the percentage of familial versus sporadic SLE among Saudi patients. The second aim of the present study is to compare clinical characteristics between the two forms of the disease. Methods: This cross-sectional study includes 47 female patients whom are selected and investigated through three phases. We have added additional two categories of relatives, based on unconventional definition. We have examined and compared demographic characteristics of the patients with familial and sporadic SLE. We have also compared the percentage of familial vs. sporadic lupus and clinical characteristics of the two forms. Results: All the patients are females, aged between 18 and 43 years. The highest percentage of patients resides in the central region of Saudi Arabia (34%). The origin of the big family or tribe also most commonly occurs in the central region (34%). Data analysis results in 27.7% of patients with familial form of SLE. Sporadic form is found in 72.3% of patients. Consanguinity between patients' parents is noticed in both familial form (61.5%) and sporadic form (58.8%). Clinical manifestations are similar between patients with familial and sporadic form. Conclusion: Our results show a high percentage of familial lupus among Saudi patients. More research is required in order to estimate the inheritance pattern of familial SLE and involvement of genetic and environmental factors.

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Section: Discussionsupporting

confidence: 88%

“…A study conducted in Al-Qaseem region of Saudi Arabia showed prevalence of SLE of 19.28 per 100,000 people [2]. There were studies showing both higher [3] and lower [4] prevalence of SLE in Saudi Arabia compared to developed countries.…”

Section: Introductionmentioning

confidence: 99%

Familial Lupus and Clinical Characteristics in Saudi Arabia

Albishri¹,

Alshehri²,

Altowairqi³

et al. 2015

IJCM

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“…Such frequencies were noted in South African and Saudi patients. 12,27 The frequency of anticardiolipin antibodies and antib2 glycoprotein I brought up in our series is probably explained by the fact that they were sought especially in cases of obstetric or thrombotic manifestations of antiphospholipid syndrome.…”

Section: 17mentioning

confidence: 83%

“…It has been postulated that the disparate course and outcome observed among patients with SLE from different populations relates to the patients' biologic and immunogenetic 1,20 features and/ or to their socioeconomic status. [7][8][9][10][11][12][13][14] Some studies have reported the frequency of clinical features of SLE in Tunisia but are often not representative of the actual spectrum of SLE because the cohort originated from a definite geographical area and does not include patients from all parts of Tunisia.…”

Section: 17mentioning

confidence: 99%

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TULUP (TUnisian LUPus): a multicentric study of systemic lupus erythematosus in Tunisia

et al. 2013

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Aim: Clinical features of systemic lupus erythematosus (SLE) have been described from different geographical regions around the world. However, data from North African countries, including Tunisia, are scarce. Methods:The aim of this retrospective multicenter study was to analyze demographic, clinical, laboratory features and outcome of SLE in Tunisia throughout 14 Departments of Internal Medicine and to compare them with those of other ethnic and geographic groups.Results: Seven hundred and forty-nine cases of SLE were recorded (American College of Rheumatology criteria) during a 17-year period (1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006). They were 676 women and 73 men with an average age at SLE onset of approximately 30.66 years. Our Tunisian patients were characterized by a high frequency of photosensitivity (67.6%), malar rash (68.7%), renal involvement (49.5%) and anti-Sm antibodies (44.8%). Infections were the main complications. Fifty-six (7.5%) patients died during the study period. Conclusion:Potential limitations and biases in our study need discussion. Specific recruitment of patients in tertiary referral centers may be the source of selection bias and adding to the frequency of moderate or even severe diseases. The therapeutic management and outcome monitoring were heterogeneous due to the fact that patients were evaluated by different doctors. However, this study remains the most representative of Tunisian SLE patients recruited from all parts of Tunisia.

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Demographic, autoimmune, and clinical profiles of patients with systemic lupus erythematosus in Oman

Al-Maini

El-Ageb

Al-Wahaibi

et al. 2003

Rheumatology International

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Seventy female and three male Omani systemic lupus erythematosus (SLE) patients are described. At disease onset, 45 (62%) were under 20 years of age, and the remainder were between 20 and 44. Of all cases, 48% were familial. Over 5 years, the cumulative frequencies of autoantibodies was: antinuclear antibodies (ANA) 97%, anti-double-stranded DNA (anti-dsDNA) antibodies 92%, extractable nuclear antigen (ENA) antibodies 64%, antineutrophil cytoplasmic antibodies (ANCA) 58%, antiphospholipid (APL) antibodies 80%, and rheumatoid factor (Rf) 22%. Ribonucleoprotein (RNP) antibodies were found in 15/45 younger-onset and 2/28 older-onset patients (chi(2)=6.63, P<0.02). The mean SLE disease activity score (SLEDAI) was 13.5+11.4, and the cumulative frequencies of systemic involvement were: neurological 33.8%, vascular 10.4%, musculoskeletal 53.9%, renal 50.7%, dermal 80.5%, serosal 23.9%, immunological 95%, constitutional 31.3%, and haematological 26.0%. Linear regression analysis showed that high-titre ANA were predictors for pyuria (odds ratio [OR] 9.06, P=0.01). Antiextractable nuclear antigen antibodies were predictors for disease of the neurological (OR 26.3, P=0.008) and serosal (OR 27.7, P=0.005) systems, and anti-Sm antibodies for alopecia (OR 5.93, P=0.088) and hypocomplementaemia (OR 14.6, P= 0.016). Antibodies of known diagnostic utility may also give insights into the pathogenesis of SLE.

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Systemic lupus erythematosus in Saudi patients

Cited by 45 publications

References 28 publications

Familial Lupus and Clinical Characteristics in Saudi Arabia

Familial Lupus and Clinical Characteristics in Saudi Arabia

TULUP (TUnisian LUPus): a multicentric study of systemic lupus erythematosus in Tunisia

Demographic, autoimmune, and clinical profiles of patients with systemic lupus erythematosus in Oman

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