Systemic lupus erythematosus in three ethnic groups: IX. Differences in damage accrual

Alarcón, Graciela S.; McGwin, Gerald; Bartolucci, Alfred A.; Roseman, Jeffrey M.; Lisse, Jeffrey R.; Fessler, Barri J.; Bastian, Holly M.; Friedman, Alan Warren; Reveille, John D.

doi:10.1002/1529-0131(200112)44:12<2797::aid-art467>3.0.co;2-9

Cited by 251 publications

(327 citation statements)

References 37 publications

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“…On the other hand, the association between the haplotype DRB1*1501 -DQB1*0602 and both DRB1*15 and DQB1*0602 alleles did not reach statistical significance after corrections. Although several studies show the association of the DRB1*1501 -DQB1*0602 and SLE [14,36], our finding is in concordance with Smerdel and col. who demonstrated only weakly elevation of DRB1*15 allele in SLE patients [35].…”

Section: Discussionsupporting

confidence: 93%

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HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population

et al. 2010

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ObjectiveThe genetic components contribute to the Systemic lupus erythematosus development. This study for the first time determined the distribution of the polymorphisms and linkage disequilibrium in HLA class II, MICA and PRL gene among patients suffering from SLE and healthy Czech individuals. Patients and Methods DNA ConclusionHLA class II-MICA combinations may increase/decrease a risk for SLE development.Multiple studies focusing on the ethnical differences as well as genetic-epigenetic relationships are necessary for better understanding SLE pathogenesis.

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Section: Discussionsupporting

confidence: 93%

“…On the other hand, the DRB1*07 allele which is supposed to be protective [13,36] was not decreased in our population. This allele may vary among populations, for example the work from neighboring country Poland, demonstrated higher frequency of this allele in a small cohort [37].…”

Section: Discussioncontrasting

confidence: 66%

HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population

et al. 2010

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“…R acial differences in the presentation and the course of systemic lupus erythematosus (SLE) are well described (1)(2)(3)(4)(5). SLE is much more common and is associated with a higher level of disease activity and poorer outcomes among black patients compared with white patients.…”

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confidence: 99%

Severe Lupus Nephritis

Korbet¹,

Schwartz

Evans³

et al. 2007

Journal of the American Society of Nephrology

253

197

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This study assessed whether certain clinicopathologic variables could explain the impact of race on outcome in 86 patients who had severe lupus nephritis and were available for long-term follow-up after participating in a prospective, controlled, clinical trial. Fifty-four (63%) patients were white, 21 (24%) were black, and 11 (13%) were categorized as other. The proportion of patients with anti-Ro, anti-nRNP, and anti-Sm was significantly greater among black patients. Biopsies with segmental active proliferative and necrotizing lesions that involved >50% of glomeruli ؎ membranous glomerulonephritis (class III >50%؎V) were significantly more common (white 44%, black 76%, other 36%; P < 0.05) and diffuse proliferative glomerulonephritis ؎ membranous glomerulonephritis (class IV؎V) was less common (white 54%, black 24%, other 64%) among black patients. Attainment of a remission was greatest among white patients (white 52%, black 29%, other 27%; P ‫؍‬ 0.09). Features that were predictive of a remission were white race, baseline serum creatinine, and class IV؎V lesions. Patient survival at 10 yr (white 81%, black 59%, other 73%; P ‫؍‬ 0.029) and renal survival at 10 yr (white 68%, black 38%, other 61%; P ‫؍‬ 0.015) were significantly poorer in black patients. Predictors of ESRD were serum creatinine, the presence of anti-Ro antibodies, class III >50%؎V lesions, and failure to achieve a remission. In conclusion, racial differences were observed in the serologic and histologic features at presentation, response to treatment, and outcome of patients with severe lupus nephritis. In a population of patients with severe lupus nephritis, black patients were significantly more likely to have a serologic profile and renal lesions that were associated with more aggressive renal disease and resulted in worse outcomes than white patients.

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“…1 Active disease, regardless of the organ system specifically affected at each point in time, reflects the presence of an ongoing inflammatory process and has been shown to be predictive of damage accrual [2][3][4][5][6][7] and mortality. [8][9][10] We previously described the factors associated with disease activity early in the disease course in patients from the Lupus in minorities: nature versus nurture (LUMINA) cohort.…”

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confidence: 99%

Systemic lupus erythematosus in a multiethnic cohort: LUMINA XXXV. Predictive factors of high disease activity over time

Alarcón

Calvo‐Alén

McGwin³

et al. 2006

Annals of the Rheumatic Diseases

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Systemic lupus erythematosus in three ethnic groups: IX. Differences in damage accrual

Cited by 251 publications

References 37 publications

HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population

HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population

Severe Lupus Nephritis

Systemic lupus erythematosus in a multiethnic cohort: LUMINA XXXV. Predictive factors of high disease activity over time

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