Systemic Lupus Erythematosus Presenting as Longitudinally Extensive Transverse Myelitis and Nephritis: A Case Report

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disorder that can potentially affect any organ. It usually presents between the ages of 15 and 45 with 9:1 ratio of female to male patients. Its clinical manifestations vary among people of different ethnicities. Longitudinally extensive transverse myelitis (LETM) is a rare life-threatening complication of SLE. We, herein, report a case of 26-year-old male diagnosed with LETM along with lupus nephritis.The patient presented with high-grade fever associated with chills and burning micturition followed by progressive bilateral lower limb weakness and urinary retention. His physical examination showed decreased bilateral lower limb power, absent reflexes, and mute plantars. His abdominal reflexes were also found to be absent and sensory level was identified at T10. T2 weighted magnetic resonance imaging (MRI) of the dorsal spine showed hyper-intense signals between T5-L1 suggestive of extensive longitudinal myelitis. Renal biopsy confirmed the presence of lupus nephritis stage III + V. Anti-nuclear antibodies (ANA) were reactive and anti-dsDNA was positive, indicative of SLE as the underlying cause of his clinical manifestations.The treatment strategy proved to be beneficial in our patient. However, there is still a vast gap between understanding the mechanisms of self-reactive diseases such as SLE and the appropriate therapeutic approach. As Pakistan’s first documented case of Lupus Myelitis, we hope to delve deeper into this matter.

Longitudinally Extensive Transverse Myelitis Associated With Systemic Lupus Erythematosus: A Case Report and Literature Review

“…Autoimmune diseases such as Sjögren’s syndrome, sarcoidosis, myasthenia gravis, inflammatory bowel disease and aPL. Among the infectious etiologies that can present with TM include cytomegalovirus, Epstein-Barr Virus, HIV, varicella zoster virus and mycobacterium tuberculosis [3,4,5,6].…”

“…Transverse myelitis can be complete or partial. In some cases, however, transverse myelitis can present in the form of a longitudinally extensive transverse myelitis (LETM), which is defined as myelitis affecting three or more contiguous segments of the spinal the cord [5]. Hereby, we present a case of LETM that occurred in a patient with SLE diagnosis which manifested as sudden onset quadriplegia.…”