Systemic nocardiosis in a dog caused by Nocardia cyriacigeorgica

Abstract

BackgroundSystemic nocardiosis due to Nocardia cyriacigeorgica has not been reported in dogs.Case presentationLight and electron microscopy, microbiological culture and molecular identification (PCR) were used to diagnose systemic nocardiosis caused by Nocardia cyriacigeorgica in a 3-month-old husky dog. The postmortem changes included multifocal to coalescing, sharply circumscribed pyogranulomatous inflammation and abscess formation in lungs, liver, myocardium, spleen, kidneys, brain, and hilar lymph nodes. The organism was isolated and sequencing of its 16S rRNA allowed its identification and speciation. Examination of the bacterial culture by scanning electron-microscope showed filamentous branching with fragmentation into widely bacillary and cocoid forms of the bacteria. There was no history of immunosupressive drug administration and infection by the immunosuppresive viral pathogens, canine distemper and parvovirus were excluded via PCR.Conclusion N. cyriacigeorgica should be considered potential cause of systemic pyogranulomatous lesions in dogs. It is the first reported case of systemic nocardiosis due to N. cyriacigeorgica in a dog.

Genomic characterization of Nocardia seriolae strains isolated from diseased fish

“…Nocardia strains are widespread in diverse habitats such as soil and water (Luo, Hiessl, & Steinbuchel, 2014). Some of pathogenic Nocardia species causing nocardiosis have been detected in human and animal such as cat, dog, and fish (Eroksuz et al, 2017;Harada et al, 2009;Kudo et al, 1988). Recently, the occurrence of nocardiosis in farming fish has been increasing gradually because of the high-environmental stresses caused by the dense cultivation of fish and environmental conditions that favor pathogens, such as like warming seawater (Le Roux et al, 2015;Pulkkinen et al, 2010).…”

“…Most Nocardia species have been isolated from natural environments, especially soils, but more than 30 species are known to cause disease in humans (Yu, Wang, Fang, Zhang, & Yan, ). Moreover, some species have been confirmed as pathogenic in animals including dogs (Eroksuz et al., ), cats (Harada, Endo, Sekiguchi, Setoguchi, & Momoi, ), and goats (Ellwood, ) as well as marine animals such as oysters (Friedman et al., ) and fish (Kudo, Hatai, & Seino, ). Nocardiosis has been identified across a diverse range of fish species, and causes mass mortality rates in economically important farming fish such as Oncorhynchus tshawytscha (Chinook salmon) (Brosnahan et al., ), Micropterus salmoides (Largemouth bass) (Ho et al., ), and Seriola dumerili (Greater amberjack) (Matsumoto, Hayashi, Suetake, Yamamoto, & Araki, ).…”

Melica Uniflora Yapraklarinin Etanoli̇k Özütleri̇ni̇n in Vitro Bi̇yoloji̇k Akti̇vi̇tesi̇ni̇n Değerlendi̇ri̇lmesi̇

“…Actinomycetes are a filamentous Gram-positive bacteria group widely distributed in soil, water, and affiliation with plants [7]. Nocardia and Micrococcus are the well known pathogenic actinomycetes for animal species and humans [8][9][10]. Especially, Nocardia causes rare but clinically important diseases, and the infections require a long duration of antibiotics [11].…”

Successful medical management of cutaneousNocardiaspecies infection in a dog receiving ciclosporin (Atopica)

“…In dogs, nocardiosis typically occurs secondary to immune suppression either from an underlying condition or from immunosuppressive therapy 5–7. The most commonly isolated species in dogs and cats is Nocardia asteroides , but infections from other species of Nocardia including N cyriacigeorgica , N veteran , N pseudobrasiliensis , N brasiliensis , N otitidiscaviarum , N nova and N Africana have been reported 3 7–9. The forms of infections that can occur in dogs include pulmonary, systemic and solitary nocardiosis 2 3.…”