Systemic photodynamic therapy with aminolaevulinic acid delays the appearance of ultraviolet-induced skin tumours in mice

Abstract

Systemic ALA-PDT can delay the appearance of UV-induced skin tumours in mice without increasing mortality or the incidence of large tumours.

Treatment of Diffuse Basal Cell Carcinomas and Basaloid Follicular Hamartomas in Nevoid Basal Cell Carcinoma Syndrome by Wide-Area 5-Aminolevulinic Acid Photodynamic Therapy

“…The lack of appearance of BCCs in the treated areas compared with the rest of the body in both patient 1 and patient 2 suggests that ALA-PDT may inhibit new BCC development, as well as new BFHs in patient 2. Whether this inhibition is due to destruction of subclinical lesions 47,48 or possibly to a local PDT-induced immune response 49 is currently being investigated.…”

Facial Basal Cell Carcinomas Recurring after Photodynamic Therapy: A Retrospective Analysis of Histological Subtypes

“…Topical PDT has only been anecdotally suspected to induce skin tumors such as melanomas [24] or keratoacanthomas [25]. In vitro and in vivo studies did not provide evidence for any carcinogenic effect on skin: both systemic and topical PDT with aminolevulinic acid delayed the occurrence of UV-induced squamous cell carcinoma in mice [26,27]. Preventive repeated MAL-PDTs have a protective effect against UV-induced tumors [28].…”

Multiple Large-Surface Photodynamic Therapy Sessions with Topical or Systemic Aminolevulinic Acid and Blue Light in UV-Exposed Hairless Mice

“…10 The first step was to reproduce as best as possible the protocol used by Stender et al 9 with topical ALA as well as the protocol used by Sharfaei et al 10 with systemic ALA. These two experiments used different UV systems.…”

“…These two experiments used different UV systems. For systemic ALA-PDT, the UV system used was identical to the source used by Sharfaei et al 10 and was made of six FS 20 tubes (Westinghouse, Bloomfield, NJ). The irradiance of this system was 1.6 mW/cm 2 for UVB and 0.82 mW/cm 2 for UVA.…”