Systemic targeted therapy beyond sorafenib

Cabrera, M.S. Roniel

doi:10.1002/cld.128

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…Molecular targeted therapy was effective in prolonging the survival of HCC patients, and [3] [17] [30] sorafenib was the most extensively studied medication [30]. Sorafenib alone was effective in 2 of our advanced HCC patients which had helped to delay the disease progression to disability and death for more than 18 months.…”

Section: Discussionmentioning

confidence: 99%

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Causes and Stages of Hepatocellular Carcinoma at Patient Presentation at a Tertiary Medical Center in Western Saudi Arabia

Alkhayyat¹,

Fallatah²,

Akbar³

et al. 2014

JCT

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Background: With 748,300 new cases diagnosed every year, hepatocellular carcinoma (HCC) is the 5 th and the 7 th most common cancer among males and females, respectively, and causes 7% of all cancer-related deaths. HCC represents more than 90% of primary liver cancers. Objective: The aim of the present study was to recognize the stages of HCC at presentation in patients who were diagnosed at King Abdul Aziz University Hospital (KAUH) and to identify the associated laboratory features of advance HCC. Materials and Methods: A retrospective analysis of 57 HCC patients admitted to KAUH between January 2008 and December 2012 was conducted. The diagnosis was established using ultrasound (U/S), computed tomography (CT) and/or magnetic resonance imaging (MRI), with or without a liver biopsy, as well as blood testing for alpha-fetoprotein. The following data were extracted from the medical records at KAUH: patient demographics (age, sex and nationality), laboratory results (CBC, LFT, PT, INR and alpha-fetoprotein), radiological results, biopsy results for those patients who underwent biopsy, outcomes (living, deceased or lost from the follow-up), and mortality and survival rates. Results: A total of 57 HCC patients were admitted during the study period, and 3 patients were excluded from the analysis. Of the remaining 54 patients, 44 (81.5%) were males and 10 (18.5%) were females. The mean age was 64.54 years (SD, 11.2 years; range, 31-86 years). The majority of patients were Saudis (19, 35.2%), non-Saudis (35, 64.8%), Egyptians (9, 16.6%) and Yemenis (7, 13%). The remaining 19 (35.2%) patients comprised other nationalities. Chronic hepatitis C virus was the most common cause for liver cirrhosis (35 patients, 64.8%). CT was the primary diagnostic method (37 patients 68.5%), while 9 (16.7%) cases were confirmed by adnominal MRI. Six patients (11.1%) were diagnosed with abdominal ultrasound * Corresponding author. S. Alkhayyat et al. 1304 examination and elevated alpha-fetoprotein levels. In 2 (3.7%) patients, HCC was confirmed by liver biopsy. The majority of the patients (37, 68.5%) had advanced disease. Only 21 (39%) patients underwent radio frequency appellation (RFA). The mean survival time from diagnosis to death was 5.9 months (SD, 5.7 months), and the longest survival time to death was 20 months. Conclusion: The majority of our patients presented at an advanced disease stage, and CHC was the most common underlying cause for liver cirrhosis in our cohort of HCC patients. The proper implementation of HCC screening programs for cirrhotic patients is expected to help detect the treatable stages of HCC in a timely manner.

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Section: Discussionmentioning

confidence: 99%

“…Sorafenib alone was effective in 2 of our advanced HCC patients which had helped to delay the disease progression to disability and death for more than 18 months. New antiangiogenic medications are currently being evaluated as monotherapy or in combination with RFA [3] [17] [30].…”

Section: Discussionmentioning

confidence: 99%

Causes and Stages of Hepatocellular Carcinoma at Patient Presentation at a Tertiary Medical Center in Western Saudi Arabia

Alkhayyat¹,

Fallatah²,

Akbar³

et al. 2014

JCT

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“…Prognosis for hepatocellular carcinoma is extremely poor without intervention (1,2) and for patients treated by ablation methods, local recurrence is frequently a challenge. Residual tumor is found upon pathological examination in up to 50% of resected livers in patients who are treated and subsequently receive a liver transplant (3,4).…”

Section: Introductionmentioning

confidence: 99%

Application of Trifluoroacetic Acid as a Theranostic Agent for Chemical Ablation of Solid Tissue

Einstein

Thompson

Guo

et al. 2020

Journal of Vascular and Interventional Radiology

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“…The incidence and mortality rate of hepatocellular carcinoma in the 21 st century continue to present significant challenges to modern medicine [1, 2]. It is an aggressive disease that frequently is diagnosed at an inoperable stage and responds poorly overall to pharmacologic intervention [3, 4]. The Barcelona Clinic Liver Cancer algorithm is perhaps the most commonly used method to guide treatment decisions for patients with intermediate stage hepatocellular carcinoma [5, 6].…”

Section: Introductionmentioning

confidence: 99%

Temperature mapping of exothermicin situchemistry: imaging of thermoembolization via MR

Fahrenholtz

Guo

MacLellan

et al. 2019

International Journal of Hyperthermia

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Purpose: MR temperature imaging (MRTI) was employed for visualizing the spatiotemporal evolution of the exotherm of thermoembolization, an investigative transarterial treatment for solid tumors. Materials and Methods: Five explanted kidneys were injected with thermoembolic solutions, and monitored by MRTI. In three nonselective experiments, 5 mL of 4 mol/L dichloroacetyl chloride (DCA-Cl) solution in a hydrocarbon vehicle was injected via the main renal artery. For two of these three, MRTI temperature data were compared to fiber optic thermal probes. Another two kidneys received selective injections, treating only portions of the kidneys with 1 mL of 2 mol/L DCA-Cl. MRTI data were acquired and compared to changes in pre- and post-injection CT. Specimens were bisected and photographed for gross pathology 24 hours post-procedure. Results: MRTI temperature estimates were within ±1°C of the probes. In experiments without probes, MRTI measured increases of 30°C. Some regions had not reached peak temperature by the end of the >18 minutes acquisition. MRTI indicated the initial heating occurred in the renal cortex, gradually spreading more proximally toward the main renal artery. Gross pathology showed the nonselective injection denatured the entire kidney whereas in the selective injections, only the treated territory was coagulated. Conclusion: The spatiotemporal evolution of thermoembolization was visualized for the first time using non-invasive MRTI, providing unique insight into the thermodynamics of thermoembolization.

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Systemic targeted therapy beyond sorafenib

Cited by 6 publications

References 21 publications

Causes and Stages of Hepatocellular Carcinoma at Patient Presentation at a Tertiary Medical Center in Western Saudi Arabia

Causes and Stages of Hepatocellular Carcinoma at Patient Presentation at a Tertiary Medical Center in Western Saudi Arabia

Application of Trifluoroacetic Acid as a Theranostic Agent for Chemical Ablation of Solid Tissue

Temperature mapping of exothermicin situchemistry: imaging of thermoembolization via MR

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