Systemic treatment for blepharokeratoconjunctivitis in children

Banteka, Marina; O’Gallagher, Michael; Bunce, Catey; Larkin, Frank; Tuft, Stephen; Dahlmann‐Noor, Annegret

doi:10.1002/14651858.cd011750

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Patients with active BKC or visually significant keratitis should be treated with long-term low-dose oral antibiotic and a course of an oral antibiotic should also be considered if there is marked blepharitis that is difficult to control with simple measures or there have been recurrent meibomian cysts. Erythromycin is the macrolide most commonly prescribed to children at doses ranging from 12.5 to 40 mg/kg body weight per day (level of evidence 4) [42]. The reported duration of systemic antibiotic treatment ranges from 1 to 23 months [18].…”

Section: Systemic Antibioticsmentioning

confidence: 99%

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Challenges in the management of pediatric blepharokeratoconjunctivis / ocular rosacea

Daniel

O’Gallagher

Hingorani

et al. 2016

Expert Review of Ophthalmology

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Introduction: Childhood blepharokeratoconjunctivitis is a common lid margin inflammation with secondary ocular surface disease. Its etiology is unclear and there are no randomized controlled trials to support the superiority of any treatment option. Areas covered: We searched the following databases; Cochrane Central Register of Controlled Trials, Ovid MEDLINE and affiliated Ovid databases, EMBASE, the ISRCTN registry, Clinical-Trials.gov and the World Health Organization International Clinical Trials Registry Platform. Due to the paucity of pediatric data we also considered information from articles focused on adults. Expert commentary: Treatment is based on the assumption that the mechanisms of BKC and rosacea keratitis are the same: meibomian gland dysfunction, bacterial colonisation of the lid margin, delayed type hypersensitivity, Demodex folliculorum, genetic predisposition and Toll-like receptors inducing release of pro-inflammatory cytokines. Generally accepted grading scales are needed. Randomized clinical trials are needed to evaluate treatment options. The effects of antibiotics, immunomodulators, osmoprotectants and essential fatty acids need further investigation. ARTICLE HISTORY

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Section: Systemic Antibioticsmentioning

confidence: 99%

“…Tetracyclines should not be prescribed for children less than 12 years of age due to the risk of staining of the dental enamel. Macrolides are usually well tolerated but can also cause gastrointestinal disturbances [42]. Other oral antibiotics (e.g.…”

Section: Systemic Antibioticsmentioning

confidence: 99%