Systemic Treatment of Psoriasis with a New Aromatic Retinoid

Goerz, G.; Orfanos, C.E.; Friedrich, Reinhard E; Happle, Rudolf; Hofbauer, M; Hornstein, M.; Jantzen, Walther; Kastrup, W; Kind, R.; Knust, T.; Landes, Erich; Mahrle, G.; Runne, U; Schimpf, A

doi:10.1159/000250883

Cited by 68 publications

(7 citation statements)

References 2 publications

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“…In other clinical trials a transient slight elevation of liver enzymes has been shown [2,4,5,12,15], that is equal to the 3 patients with slight eleva tion of a single liver parameter in just one examination in our material.…”

Section: Discussionsupporting

confidence: 55%

“…With regard to more unpleasant side effects our results corre spond to other materials. 5 of our patients had diffuse hair loss, which others have found in up to a third of the patients [2,5,15,16]. One had epostaxis and 1 patient conjunctivitis, as seen by others as infrequent side effects [2,15], Some authors reported pruritus, thinning of the skin, bala nitis, hyperhidrosis, impression of cold, headache as well as palmoplantar desquamation and fissures [1,4,5,15], None of these side effects were found in our study, and with regard to desquamation and fissures, these were not counted for reasons mentioned above.…”

Section: Discussionsupporting

confidence: 48%

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Side Effects Due to RO 10-9359 (Tigason)

Foged

Jacobsen

1982

Dermatology

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In a retrospective study clinical and hepatotoxic side effects caused by Tigason treatment are investigated. The material consists of data on 27 patients with normal liver function tests at the beginning of treatment. The clinical side effects encountered were: dryness of lips and mucous membranes (n = 14), diffuse hair loss (n = 5), epistaxis (n = 1) and conjunctivitis (n = 1). Abnormal liver function tests (glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactate dehydrogenase and alkaline phosphatase) were found in 7 patients: 3 developed slight transient elevation of parameter during treatment, 2 transient elevation of more parameters, normalizing despite continued therapy in 1 and in the other normalizing after discontinuation. Finally 2 patients developed persistent elevation of one or more parameters. In the last 2 patients liver biopsy showed changes of toxic hepatitis.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionsupporting

confidence: 48%

Side Effects Due to RO 10-9359 (Tigason)

Foged

Jacobsen

1982

Dermatology

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“…The elevation of serum alkaline phosphatase coincides with the reports of Dahl el at. [9], and the alteration of transaminases with those of Goerz and Orfanos [10]. Both changes are transitory, and there seems to be no relationship with dosage or duration of treatment.…”

Section: Commentsmentioning

confidence: 90%

Oral Retinoid (Ro 10-9359) in Children with Lamellar Ichthyosis, Epidermolytic Hyperkeratosis and Symmetrical Progressive Erythrokeratoderma

Tamayo¹,

Ruíz-Maldonado²

1980

Dermatology

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8 children with lamellar ichthyosis, 1 with epidermolytic hyperkeratosis and 5 with symmetrical progressive erythrokeratoderma were treated with a new aromatic retinoid (Ro 10-9359). Clinical improvement was dramatic. The children acquired an appearance never obtained before with other managements. The treatment had to be maintained to prevent recurrence. The tolerance to the drug was good. The side-effects were minimal and tended to disappear after several months of treatment. Our results suggest that because of its efficacy, good tolerance and easy administration, the oral retinoid Ro 10-9359 is at present the treatment of choice for the great ichthyotic disorders of children.

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“…The concern for retinol-induced liver damage was raised by a number of observations related to over consumption of vitamin A supplements, usually with out medical prescription or control [14], A limited number of studies in patients treated with retinoids or vitamin A have provided an objective evaluation of biochemical changes associated with treatment [13,[24][25][26][27][28]. Most of these studies were not randomized, and referred to various synthetic compounds adminis tered with different dose-duration schedules.…”

Section: Discussionmentioning

confidence: 99%

Safety of High-Dose Vitamin A

et al. 1991

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The paper reports on the efficacy and side effects of high-dose vitamin A, administered as adjuvant treatment for resected stage I lung cancer in a randomized clinical trial. After a median follow-up of 28 months, 283 patients were evaluable: 138 allocated to treatment with retinol palmitate (300,000 IU daily for at least 12 months) and 145 to standard observation. The clinical results available to date do well justify a continuation of the study. Skin dryness and desquamation were the most frequent symptoms, affecting 60% of all treated patients. Other symptoms such as dyspepsia, headache, nosebleeds and mild hair loss occurred in less than 10% of patients, and were self-terminating. Only in 4 patients (3%) was the treatment interrupted because of symptoms potentially related to vitamin A administration. As for laboratory tests, Γ-GT levels were abnormally elevated in 69% of treated patients vs. 39% of controls at 24 months (mean 149 vs. 58 IU/1; p < 0.05). Serum triglyceride concentrations over 150mg/dl were seen in 74% of treated patients vs. 43% of controls at 12 months (mean 283 vs. 179mg/dl; p < 0.05). There were no other laboratory signs of toxicity attributable to vitamin A. In our experience, high-dose retinoyl palmitate administration was a well-tolerated and safe treatment. The long-term impact on lipid metabolism still remains to be determined.

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Systemic Treatment of Psoriasis with a New Aromatic Retinoid

Cited by 68 publications

References 2 publications

Side Effects Due to RO 10-9359 (Tigason)

Side Effects Due to RO 10-9359 (Tigason)

Oral Retinoid (Ro 10-9359) in Children with Lamellar Ichthyosis, Epidermolytic Hyperkeratosis and Symmetrical Progressive Erythrokeratoderma

Safety of High-Dose Vitamin A

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