Systemic Vasculitis Resembling Periarteritis Nodosa in the Lupus-Like Syndrome Induced by Hydralazine

Minocycline-Induced Lupus and Autoimmune Hepatitis: Family Autoimmune Disorders as Possible Risk Factors

“…Of note, the presence of p-ANCA is suggested to be a marker for lupus symptoms in genetically susceptible individuals treated with minocycline for acne in relation with certain major histocompatibility complex class II genes including HLA-DR4, HLA-DR2 and HLA-DQB1, as observed in our patient [4]. Indeed, p-ANCA antibodies have been reported in druginduced autoimmune disorders such as hydralazine-induced lupus, and vasculitis and propylthiouracil-associated vasculitis [5][6][7]. The role of HLA-DR4 has been implicated in the development of hydralazine-induced lupus [8].…”

Hydralazine-induced autoimmune disease: comparison to idiopathic lupus and ANCA-positive vasculitis

“…Sixty-six cases of hydralazine-induced vasculitis from 18 papers were identified [3,7,8,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Cases described in two papers were excluded because of duplicate patients [9,10].…”

Hydralazine-induced vasculitis presenting with ocular manifestations

“…In 2002, Holder et al conducted an extensive review of drug-induced vasculitis, which reported 25 cases associated with hydralazine. 18 Presenting symptoms of hydralazine-induced vasculitis included arthralgias and myalgias, and manifestations can also include hoarseness and retinal vascular inflammation, 2 , 4 , 8 , 19 , 20 , 21 which develop between six months to thirteen years after initiation of hydralazine treatment. 18 The cases were characterized by positive ANA, p-ANCA, and anti-dsDNA antibodies.…”