Systems approach identifies an organic nitrogen-responsive gene network that is regulated by the master clock control gene
            <i>CCA1</i>

Gutiérrez, Rodrigo A.; Stokes, Trevor; Thum, Karen E.; Xu, Xiaodong; Obertello, Mariana; Katari, Manpreet S.; Tanurdžić, Miloš; Dean, Alexis; Nero, Damion; McClung, C. Robertson; Coruzzi, Gloria M.

doi:10.1073/pnas.0800211105

Cited by 339 publications

(321 citation statements)

References 47 publications

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“…Nitrogen status also modulates the circadian clock by serving as an input (Scheible et al, 2004;Gutierrez et al, 2008). Moreover, the carbon-nitrogen ratio in plants is tightly regulated, with interconnected sensing and signaling mechanisms (Coruzzi and Zhou, 2001).…”

Section: Bt2 Responds To Changes In Nutrient Status Of the Plantmentioning

confidence: 99%

“…Changes in light, the circadian clock, and nutrient status serve as major inputs to modulate the diurnal expression of networks of genes that regulate growth and development (Blasing et al, 2005;Gutierrez et al, 2008;Usadel et al, 2008). The circadian clock further serves as an input to regulate or "gate" the expression of multiple genes involved in metabolism, growth, and development, thereby rendering a physiological advantage for plant growth and survival (for review, see McClung, 2006).…”

mentioning

confidence: 99%

“…Global gene expression studies in Arabidopsis (Arabidopsis thaliana) have revealed that specific signals modulate extensive networks of genes. These networks typically include genes encoding putative transcription factors and protein kinases, along with genes involved in protein synthesis and ubiquitin-mediated protein degradation (Wang et al, 2004;Blasing et al, 2005;Gutierrez et al, 2008;Usadel et al, 2008). Members of the bZIP family of transcription factors characterized as G box (CACGTG)-binding factors (GBFs), such as bZIP2/ GBF5 and bZIP11/ATB1, together with Snf1-related kinases (SnRK), KIN10/11, orchestrate synergistic transcriptional networks in response to sugar, energy deprivation, and diverse stresses (Baena-Gonzalez et al, 2007;Hanson et al, 2008).…”

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confidence: 99%

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BT2, a BTB Protein, Mediates Multiple Responses to Nutrients, Stresses, and Hormones in Arabidopsis

et al. 2009

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The Arabidopsis (Arabidopsis thaliana) gene BT2 encodes a 41-kD protein that possesses an amino-terminal BTB domain, a central TAZ domain, and a carboxyl-terminal calmodulin-binding domain. We previously demonstrated that BT2 could activate telomerase expression in mature Arabidopsis leaves. Here, we report its distinct role in mediating diverse hormone, stress, and metabolic responses. We serendipitously discovered that steady-state expression of BT2 mRNA was regulated diurnally and controlled by the circadian clock, with maximum expression in the dark. This pattern of expression suggested that BT2 mRNA could be linked to the availability of photosynthate in the plant. Exogenous sugars decreased BT2 expression, whereas exogenous nitrogen increased expression. bt2 loss-of-function mutants displayed a hypersensitive response to both sugar-mediated inhibition of germination and abscisic acid (ABA)-mediated inhibition of germination, thus supporting a role of ABA in sugar signaling in germination and development. Moreover, constitutive expression of BT2 imparted resistance to both sugars and ABA at germination, suggesting that BT2 suppresses sugar and ABA responses. In support of the previously described antagonistic relationship between ABA and auxin, we found that BT2 positively regulated certain auxin responses in plants, as revealed by knocking down BT2 expression in the high-auxin mutant yucca. Accumulation of BT2 mRNA was affected by a variety of hormones, nutrients, and stresses, and BT2 was required for responses to many of these same factors. Together, these results suggest that BT2 is a central component of an interconnected signaling network that detects and responds to multiple inputs.

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Section: Bt2 Responds To Changes In Nutrient Status Of the Plantmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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BT2, a BTB Protein, Mediates Multiple Responses to Nutrients, Stresses, and Hormones in Arabidopsis

et al. 2009

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“…Considering the critical roles amino acids play in N assimilation and transport, it is not surprising that the change in amino acid levels induce a rapid change in transcriptome and in the activities of key enzymes in the N assimilation pathway. 2,3 In fact, amino acids have long been suggested as signals that regulate genes involved in N transport and metabolism in plants, but the exact mechanism of amino acid sensing in plants is not well understood. 4,5 Some mechanisms for amino acid sensing have been documented in bacteria, yeast, and mammals, and potential homologs of such amino acid sensors from other organisms do exist in plants.…”

Section: Introductionmentioning

confidence: 99%

Inter-subunit interactions between Glutamate-Like Receptors inArabidopsis

Price

Kong

Okumoto

2013

Plant Signaling & Behavior

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“…Mineral nutritional status, specifically an organic nitrogen metabolite, has been recently reported to affect the circadian clock in Arabidopsis (Gutierrez et al, 2008). A wide variety of biological processes are subjected to circadian clock control that translates environmental, light and temperature, and endogenous cycles into integrated temporal signals to rhythmically schedule physiology and metabolism at the adequate timing.…”

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confidence: 99%

Deregulated Copper Transport Affects Arabidopsis Development Especially in the Absence of Environmental Cycles

et al. 2010

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Copper is an essential cofactor for key processes in plants, but it exerts harmful effects when in excess. Previous work has shown that the Arabidopsis (Arabidopsis thaliana) COPT1 high-affinity copper transport protein participates in copper uptake through plant root tips. Here, we show that COPT1 protein localizes to the plasma membrane of Arabidopsis cells and the phenotypic effects of transgenic plants overexpressing either COPT1 or COPT3, the latter being another high-affinity copper transport protein family member. Both transgenic lines exhibit increased endogenous copper levels and are sensitive to the copper in the growth medium. Additional phenotypes include decreased hypocotyl growth in red light and differentially affected flowering times depending on the photoperiod. Furthermore, in the absence of environmental cycles, such as light and temperature, the survival of plants overexpressing COPT1 or COPT3 is compromised. Consistent with altered circadian rhythms, the expression of the nuclear circadian clock genes CIRCADIAN CLOCK-ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) is substantially reduced in either COPT1-or COPT3-overexpressing plants. Copper affects the amplitude and the phase, but not the period, of the CCA1 and LHY oscillations in wild-type plants. Copper also drives a reduction in the expression of circadian clock output genes. These results reveal that the spatiotemporal control of copper transport is a key aspect of metal homeostasis that is required for Arabidopsis fitness, especially in the absence of environmental cues.

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Systems approach identifies an organic nitrogen-responsive gene network that is regulated by the master clock control gene CCA1

Cited by 339 publications

References 47 publications

BT2, a BTB Protein, Mediates Multiple Responses to Nutrients, Stresses, and Hormones in Arabidopsis

BT2, a BTB Protein, Mediates Multiple Responses to Nutrients, Stresses, and Hormones in Arabidopsis

Inter-subunit interactions between Glutamate-Like Receptors inArabidopsis

Deregulated Copper Transport Affects Arabidopsis Development Especially in the Absence of Environmental Cycles

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