Systems Biology Approaches for the Prediction of Possible Role of Chlamydia pneumoniae Proteins in the Etiology of Lung Cancer

Abstract

Accumulating evidence has recently supported the association of bacterial infection with the growth and development of cancers, particularly in organs that are constantly exposed to bacteria such as the lungs, colon, cervical cancer etc. Our in silico study on the proteome of Chlamydia pneumoniae suggests an unprecedented idea of the etiology of lung cancer and have revealed that the infection of C. pneumoniae is associated with lung cancer development and growth. It is reasonable to assume that C. pneumoniae transports its proteins within host-intracellular organelles during infection, where they may work with host-cell proteome. The current study was performed for the prediction of nuclear targeting protein of C. pneumoniae in the host cell using bioinformatics predictors including ExPASy pI/Mw tool, nuclear localization signal (NLS) mapper, balanced sub cellular localization predictor (BaCeILo), and Hum-mPLoc 2.0. We predicted 47/1112 nuclear-targeting proteins of C. pneumoniae connected with several possible alterations in host replication and transcription during intracellular infection. These nuclear-targeting proteins may direct to competitive interactions of host and C. pneumoniae proteins with the availability of same substrate and may be involved as etiological agents in the growth and development of lung cancer. These novel findings are expected to access in better understanding of lung cancer etiology and identifying molecular targets for therapy.

Fecal microbiota transplantation in cancer management: Current status and perspectives

“…5 Various studies have shown that microbial alternations, characterized by a marked increase in the numbers of pathogens and a relative decrease in levels of beneficial bacteria, are connected with the development of gastrointestinal and extra-gastrointestinal cancers. [6][7][8][9][10][11][12][13] Altering the gut microbiota is expected as a novel method to deal with diseases associated with intestinal dysbiosis. Potential routes to target intestinal microbiota community include diet, probiotics, prebiotics, antibiotics and fecal microbiota transplantation (FMT).…”

Difference of lower airway microbiome in bilateral protected specimen brush between lung cancer patients with unilateral lobar masses and control subjects

“…While studies targeting at the direct relationship between lung cancer and lung microbiome are quite limited at present, there have been interesting studies documenting persistent lung infections and inflammation can favor carcinogenesis . And certain types of microbial agents or products may positively or negatively modulate lung cancer development and/or progression .…”

“…While studies targeting at the direct relationship between lung cancer and lung microbiome are quite limited at present, there have been interesting studies documenting persistent lung infections and inflammation can favor carcinogenesis. [25][26][27][28][29][30][31][32] And certain types of microbial agents or products may positively or negatively modulate lung cancer development and/or progression. 27,30,32,33 A large epidemiological study in humans suggested that the frequency of lung cancer increases upon use of repeated courses of antibiotics providing circumstantial evidence that some links may exist between the bacterial microbiota and lung cancer.…”

“…[25][26][27][28][29][30][31][32] And certain types of microbial agents or products may positively or negatively modulate lung cancer development and/or progression. 27,30,32,33 A large epidemiological study in humans suggested that the frequency of lung cancer increases upon use of repeated courses of antibiotics providing circumstantial evidence that some links may exist between the bacterial microbiota and lung cancer. 34 To date, three studies using highthroughput sequencing for bacterial identification characterized the lung microbiome in lung cancer patients, respectively using sputum samples, 18 tissue samples 5 and bronchoalveolar fluid samples (BALF).…”

Identification of novel genes associated with a poor prognosis in pancreatic ductal adenocarcinoma via a bioinformatics analysis

“…The association of infectious agents in the etiology of different types of cancer has piqued the interest of scientists in recent years. Recent data have shown the involvement of Mycoplasma hominis, Chlamydia pneumoniae, and Escherichia coli infection in the etiology of prostate cancer, lung cancer, and colon cancer, respectively [9][10][11][12]. Recently, a wealth of previous studies have reported that microRNAs (miRNAs), a class of noncoding RNAs characterized by approximately 22 nucleotides in length, can inhibit the stability and translation of messenger RNAs (mRNAs) through binding to the specific sequence of genes, which are used as potential biomarkers for different kinds of cancer.…”