2017
DOI: 10.1111/ajt.13881
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Systems Biology in Kidney Transplantation: The Application of Multi-Omics to a Complex Model

Abstract: In spite of reduction of rejection rates and improvement in short-term survival post-kidney transplantation, modest progress has occurred in long-term graft attrition over the years. Timely identification of molecular events that precede clinical and histopathological changes might help in early intervention and thereby increase the graft half-life. Evolution of "omics" tools has enabled systemic investigation of the influence of the whole genome, epigenome, transcriptome, proteome and microbiome on transplant… Show more

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Cited by 31 publications
(23 citation statements)
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“…There are a large number of emerging technologies that examine the function of an organ on a molecular level. Ranging from proteomics, metabolomics to transcription studies, these innovative methods help us to better understand ischemic‐reperfusion injury mechanisms and immunologic or inflammatory processes . Even though most of these molecular approaches are still at an early stage with relatively small‐scale experiments and no validation in clinical trials, the potential for practice‐changing discoveries in this field is promising.…”
Section: Emerging Techniquesmentioning
confidence: 99%
“…There are a large number of emerging technologies that examine the function of an organ on a molecular level. Ranging from proteomics, metabolomics to transcription studies, these innovative methods help us to better understand ischemic‐reperfusion injury mechanisms and immunologic or inflammatory processes . Even though most of these molecular approaches are still at an early stage with relatively small‐scale experiments and no validation in clinical trials, the potential for practice‐changing discoveries in this field is promising.…”
Section: Emerging Techniquesmentioning
confidence: 99%
“…Inhibitori skupine deacetilaza imaju protuupalni učinak te zaustavljaju fibrozu tkiva bubrega, što se potencijalno može koristiti u mehanizmu djelovanja imunosupresivne terapije 33 . Dosadašnje spoznaje temelje se na istraživanjima provedenima na životinjskim modelima, stoga su neophodne daljnje studije koje bi u budućnosti imale klinički značaj [34][35][36][37] . 41 .…”
Section: Modifikacija Histona I Njen Utjecaj Na Događaje Prije I Poslunclassified
“…A variety of innovative technologies, ranging from genomics, proteomics, peptidomics, antibodyomics, microbiomics and metabolomics, among others, all referred to as “omics”, have emerged in medical fields, to generate new biomarkers[12] .…”
Section: Definition and Principal Characteristics Of The Biological Mmentioning
confidence: 99%