2012
DOI: 10.1038/ki.2011.314
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Systems biology of kidney diseases

Abstract: Kidney diseases manifest in progressive loss of renal function, which ultimately leads to complete kidney failure. The mechanisms underlying the origins and progression of kidney diseases are not fully understood. Multiple factors involved in the pathogenesis of kidney diseases have made the traditional candidate gene approach of limited value toward full understanding of the molecular mechanisms of these diseases. A systems biology approach that integrates computational modeling with large-scale data gatherin… Show more

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Cited by 73 publications
(40 citation statements)
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References 128 publications
(136 reference statements)
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“…Our increasing understanding of molecular (genetic, epigenetic, transcriptomic, proteomic, metabolomics) [36], clinical, environmental, socioeconomic data, and of the renal disease pathophysiology [37] demand that novel quantitative approaches, suitable for dataset integration, are developed. Three different tissue interrogation approaches exploit digital pathology in clinical research: visual morphologic assessment; visual morphometric assessment; and computer-aided assessment (Table 1).…”
Section: Digital Pathology In Clinical Researchmentioning
confidence: 99%
“…Our increasing understanding of molecular (genetic, epigenetic, transcriptomic, proteomic, metabolomics) [36], clinical, environmental, socioeconomic data, and of the renal disease pathophysiology [37] demand that novel quantitative approaches, suitable for dataset integration, are developed. Three different tissue interrogation approaches exploit digital pathology in clinical research: visual morphologic assessment; visual morphometric assessment; and computer-aided assessment (Table 1).…”
Section: Digital Pathology In Clinical Researchmentioning
confidence: 99%
“…We can consider how to relate these NS-associated intermediates to underlying genetic variation. Similar approaches have contributed to our integrated, systems genomics approach to NS [18,19,45,46]. …”
Section: Analytic Challenges Of Genome-scale Data In Glomerular Diseasementioning
confidence: 99%
“…Several previous reviews are excellent resources for the specifics of the techniques used [11] [12] [13] [14] [15] [16] [17]. We focus on rationale of these “omics” approaches, and highlight pertinent examples of early progress integrating different layers within the genome-phenome continuum.…”
Section: Introductionmentioning
confidence: 99%