Systems for stimuli-controlled release: Materials and applications

Bruneau, Marion; Bennici, Simona; Brendlé, Jocelyne; Dutournié, Patrick; Limousy, Lionel; Pluchon, Sylvain

doi:10.1016/j.jconrel.2018.12.038

Cited by 104 publications

(52 citation statements)

References 141 publications

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“…The development of controlled drug delivery systems has generated substantial interest in pharmaceutical science in recent years [1,2,3]. In particular, transdermal drug delivery has attracted researchers with multiple approaches because multiple dosing or insufficient drug delivery often results in low therapeutic effects [4,5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Tran

2019

Pharmaceutics

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Despite many available approaches for transdermal drug delivery, patient compliance and drug targeting at the desired concentration are still concerns for effective therapies. Precise and efficient film-forming systems provide great potential for controlling drug delivery through the skin with the combined advantages of films and hydrogels. The associated disadvantages of both systems (films and hydrogels) will be overcome in film-forming systems. Different strategies have been designed to control drug release through the skin, including changes to film-forming polymers, plasticizers, additives or even model drugs in formulations. In the current review, we aim to discuss the recent advances in film-forming systems to provide the principles and review the methods of these systems as applied to controlled drug release. Advances in the design of film-forming systems open a new generation of these systems.

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Section: Introductionmentioning

confidence: 99%

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Tran

2019

Pharmaceutics

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“…Coumarin and o -nitrobenzyl groups containing polymers can be cleaved into smaller molecules, while structures of azobenzene and spyropyrane polymers can be induced reversibly in the presence of certain wavelength light [62]. Light-controlled release can also act as an on/off system, where the presence of light stimulates the release of active compounds, while in the absence of light, or at a different light frequency, the system may be reversed and the release is interrupted [63] (Fig. 6).…”

Section: Types Of Stimuli-responsive Systemsmentioning

confidence: 99%

Development of stimuli-responsive nano-based pesticides: emerging opportunities for agriculture

et al. 2019

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Pesticides and fertilizers are widely used to enhance agriculture yields, although the fraction of the pesticides applied in the field that reaches the targets is less than 0.1%. Such indiscriminate use of chemical pesticides is disadvantageous due to the cost implications and increasing human health and environmental concerns. In recent years, the utilization of nanotechnology to create novel formulations has shown great potential for diminishing the indiscriminate use of pesticides and providing environmentally safer alternatives. Smart nano-based pesticides are designed to efficiently delivery sufficient amounts of active ingredients in response to biotic and/or abiotic stressors that act as triggers, employing targeted and controlled release mechanisms. This review discusses the current status of stimuli-responsive release systems with potential to be used in agriculture, highlighting the challenges and drawbacks that need to be overcome in order to accelerate the global commercialization of smart nanopesticides.

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“…Although alginate-based DDSs can selectively accumulate in the target site via passive or active targeting, some strategies are needed to disassemble the DDSs after entering the cancer tissues. Stimuli-responsive DDSs can take advantage of the specific microenvironmental changes in tumors such as a harsh redox environment, acidic condition, and certain types of enzymes, and release their cargo in desired sites [ 128 – 130 ]. Alternatively, they can be designed to respond to externally applied physical stimuli such as temperature, ultrasound, electric fields, magnetic field, and X-rays [ 129 ].…”

Section: Functionalization Strategies Of Alginate-based Platforms mentioning

confidence: 99%

Alginate-Based Platforms for Cancer-Targeted Drug Delivery

Shang

et al. 2020

BioMed Research International

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As an acidic, ocean colloid polysaccharide, alginate is both a biopolymer and a polyelectrolyte that is considered to be biocompatible, nontoxic, nonimmunogenic, and biodegradable. A significant number of studies have confirmed the potential use of alginate-based platforms as effective vehicles for drug delivery for cancer-targeted treatment. In this review, the focus is on the formation of alginate-based cancer-targeted delivery systems. Specifically, some general chemical and physical properties of alginate and different types of alginate-based delivery systems are discussed, and various kinds of alginate-based carriers are introduced. Finally, recent innovative strategies to functionalize alginate-based vehicles for cancer targeting are described to highlight research towards the optimization of alginate.

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Systems for stimuli-controlled release: Materials and applications

Cited by 104 publications

References 141 publications

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

Development of stimuli-responsive nano-based pesticides: emerging opportunities for agriculture

Alginate-Based Platforms for Cancer-Targeted Drug Delivery

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