Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response

Li, Zhuoyuan Alex; Bajpai, Akhilesh Kumar; Wang, Ruixue; Liu, Yaxin; Webby, Richard J.; Wilk, Esther; Gu, Weikuan; Schughart, Klaus; Li, Kui; Lu, Lu

doi:10.1016/j.virusres.2024.199335

Cited by 3 publications

(1 citation statement)

References 63 publications

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“…Pathway analysis found TRIM21 involved in inflammation- and immunity-related signaling pathways. Subsequently, knockdown of TRIM21 in A549 cells led to significantly augmented levels of IAV-induced expression of IFNB1, IFNL1, CCL5, CXCL10, and ISGs ( Li ZA. et al., 2024 ).…”

Section: Influenza a Virusmentioning

confidence: 99%

Exploring TRIM proteins’ role in antiviral defense against influenza A virus and respiratory coronaviruses

Wei,

Song,

Zhang

et al. 2024

Front. Cell. Infect. Microbiol.

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Numerous tripartite motif (TRIM) proteins, identified as E3 ubiquitin ligases, participate in various viral infections through ubiquitylation, ISGylation, and SUMOylation processes. Respiratory viruses, particularly influenza A virus (IAV) and respiratory coronaviruses (CoVs), have severely threatened public health with high morbidity and mortality, causing incalculable losses. Research on the regulation of TRIM proteins in respiratory virus infections is crucial for disease prevention and control. This review introduces TRIM proteins, summarizes recent discoveries regarding their roles and molecular mechanisms in IAV and CoVs infections, discusses current research gaps, and explores potential future trends in this rapidly developing field. It aims to enhance understanding of virus–host interactions and inform the development of new molecularly targeted therapies.

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Section: Influenza a Virusmentioning

confidence: 99%

Exploring TRIM proteins’ role in antiviral defense against influenza A virus and respiratory coronaviruses

Wei,

Song,

Zhang

et al. 2024

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

Key roles for phosphorylation and the Coiled-coil domain in TRIM56-mediated positive regulation of TLR3-TRIF–dependent innate immunity

Liu,

Li,

Wang

et al. 2024

Journal of Biological Chemistry

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The Regulation of Innate Antiviral Immunity by TRIM56

Li,

Lee

2024

Infectious Diseases &Amp; Immunity

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A member of the tripartite-motif (TRIM) protein family of E3 ligases, TRIM56 has increasingly been recognized as a versatile player in innate antiviral immunity that operates via catalytically-dependent and catalytically-independent mechanisms. Herein, we provide a concise overview of the various roles that TRIM56 has been demonstrated to play in host interactions with viruses, including its "direct" virus-restricting activities and "indirect" antiviral effects resulting from its positive regulation of innate immune signaling. In addition, we discuss the current understanding of the molecular determinants and underlying biology by which TRIM56 functions in these processes.

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Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response

Cited by 3 publications

References 63 publications

Exploring TRIM proteins’ role in antiviral defense against influenza A virus and respiratory coronaviruses

Exploring TRIM proteins’ role in antiviral defense against influenza A virus and respiratory coronaviruses

Key roles for phosphorylation and the Coiled-coil domain in TRIM56-mediated positive regulation of TLR3-TRIF–dependent innate immunity

The Regulation of Innate Antiviral Immunity by TRIM56

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