Systems Pharmacological Approach of <i>Pulsatillae Radix</i> on Treating Crohn’s Disease

Suh, Su Yeon; An, Won Gun

doi:10.1155/2017/4198035

Cited by 15 publications

(15 citation statements)

References 73 publications

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“…Additionally, the compound-target network showed multiple compounds and multiple targeting characteristics of ASF. Multiple compounds and multiple targeting actions of other herbal medicines such as licorice [47], Xiao-Chaihu Decoction, Da-Chaihu Decoction [48], Pulsatillae Radix, Baekduong-tang [49,50], and Bulsusan [51] have also been studied. Based on our results, we propose that ASF is a potential antileukemic agent.…”

Section: Discussionmentioning

confidence: 99%

Systemic Pharmacological Approach to Identification and Experimental Verification of the Effect of Anisi Stellati Fructus Extract on Chronic Myeloid Leukemia Cells

Kim

Suh

Ahn

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Anisi stellati fructus (ASF) is the dried fruit of the Illicium verum Hook.f. tree. e aim of this research was to evaluate the antileukemic effect of ASF on chronic myeloid leukemia (CML) cells, which was hypothesized from the systemic pharmacological analysis of ASF, focusing on the combined effect of ASF extract (ASFE) and imatinib (IM). e compounds of ASF were identified using the Traditional Chinese Medicine Systems Pharmacology database and analysis platform. e target gene information was acquired from the UniProt database. e compound and target interaction network was generated from Cytoscape 3.7.1. Using this analysis, 10 compounds effective against CML cells were obtained. ASFE was prepared and analyzed by high-pressure liquid chromatography to provide experimental proof for the relationship between ASF and CML. e anti-p210 Bcr-Abl effects of ASFE and ASFE + IM combination were evaluated by western blotting. Either ASFE alone or in combined treatment with IM on K-562 CML cells resulted in a significant reduction of the Bcr-Abl levels. As expected from the systemic analysis results, ASF had antileukemic activity, showing that it is a potential therapy for CML.

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Section: Discussionmentioning

confidence: 99%

Systemic Pharmacological Approach to Identification and Experimental Verification of the Effect of Anisi Stellati Fructus Extract on Chronic Myeloid Leukemia Cells

Kim

Suh

Ahn

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…No metal was used in the herbal preparation. All ingredients were well identified by taxonomist (36), were non-toxic, and could be useful in the treatment of the symptoms similar to those of Crohn's disease (1,24).…”

Section: Therapeutic Interventionmentioning

confidence: 99%

“…Crohn's disease (an inflammatory bowel disease -IBD) is a chronic gastrointestinal inflammatory disorder (1)(2)(3)(4)(5)(6)(7)(8)(9). Although it is a widespread disease, its etiology and mechanism are still not properly understood (2).…”

Section: Introductionmentioning

confidence: 99%

“…Although it is a widespread disease, its etiology and mechanism are still not properly understood (2). Crohn's disease usually affects the large intestine (colon) and the small intestine (ileum) (1). Common symptoms of Crohn's disease include rectal bleeding, persistent diarrhea, abdominal pain, extreme fatigue, weight loss, constipation, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Common symptoms of Crohn's disease include rectal bleeding, persistent diarrhea, abdominal pain, extreme fatigue, weight loss, constipation, etc. (1) Other complications include anemia, liver disease, etc.…”

Section: Introductionmentioning

confidence: 99%

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An Integrated Traditional Therapy Approach Involving Yagya Therapy In Patient With Symptoms Similar to Crohn's Disease

Shrivastava¹,

Batham²,

Mishra³

et al. 2019

Interdis. J of Yagya Res.

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Background: Crohn’s disease (an inflammatory bowel disease - IBD) is a chronic gastrointestinal inflammatory disorder. Common symptoms include rectal bleeding, persistent diarrhea, abdominal pain, extreme fatigue, weight loss, constipation, etc. Although it is a widespread disease, its etiology and mechanism are still not properly understood. Hence, even though several treatment methodologies have been employed for the management of the symptoms associated with the Crohn's disease - side-effect free, long-term management of this disease is still not achieved. Purpose: As per the classical texts of Ayurveda, Pachak Pitta, Saman Vayu and Kledak Kapha are responsible for proper digestion; vikriti (vitiation) of these Doshas can lead to various types of diseases of the gastrointestinal tract. Hence, herbal medicines that balance these Doshas, as well as provide nourishment to the body tissues, can be recommended for the management of the observed symptoms of the disease in the present study. Yagya Therapy provides pulmonary inhalation of medicinal smoke of multiple herbs (generated through oblation in fire along with chanting of Vedic hymns), which provide therapeutic benefits. The Vedic hymns also contribute to the positive restructuring of the psyche of the patient. Methodology: A case report about a male patient, who was suffering from symptoms similar to those found in Crohn's disease, has been presented in this article. The patient was prescribed an integrated approach pivoting on Yagya Therapy (using an appropriate herbal formulation - hawan-samagri), and some other Ayurvedic treatments like decoction of medicinal herbs, dietary restrictions, etc. Results: Before starting the integrated approach involving Yagya Therapy , the patient used to have severe pain in the abdomen, had swelling and stiffness in legs, had constipation, as well as weight loss; after taking the integrated approach involving Yagya Therapy , there was significant relief in the pain, the swelling in the legs was completely resolved, the stiffness in the legs had reduced, constipation was significantly reduced, as well as there was slight increase in weight. Earlier, because of weakness, the patient had difficulty in walking, changing posture from sitting to standing and vice versa, changing side while lying down; after taking the integrated approach, the patient feels an enhanced strength in his legs, has started walking on his own, can change posture from sitting to standing and vice versa on his own, can change side while lying down on his own. Overall, there was definite improvement in the condition of the patient. Conclusion: The integrated approach involving Yagya Therapy showed encouraging results with respect to the management of symptoms similar to those found in Crohn's disease.

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Mechanisms underlying the therapeutic effects of Qingfeiyin in treating acute lung injury based on GEO datasets, network pharmacology and molecular docking

Wang

Yuan

Wang

et al. 2022

Computers in Biology and Medicine

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Systems Pharmacological Approach of Pulsatillae Radix on Treating Crohn’s Disease

Cited by 15 publications

References 73 publications

Systemic Pharmacological Approach to Identification and Experimental Verification of the Effect of Anisi Stellati Fructus Extract on Chronic Myeloid Leukemia Cells

Systemic Pharmacological Approach to Identification and Experimental Verification of the Effect of Anisi Stellati Fructus Extract on Chronic Myeloid Leukemia Cells

An Integrated Traditional Therapy Approach Involving Yagya Therapy In Patient With Symptoms Similar to Crohn's Disease

Mechanisms underlying the therapeutic effects of Qingfeiyin in treating acute lung injury based on GEO datasets, network pharmacology and molecular docking

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