Systems pharmacology-based mechanism exploration of Acanthopanax senticosusin for Alzheimer's disease using UPLC-Q-TOF-MS, network analysis, and experimental validation

Zhuo, Yue; Fu, Xiaomei; Jiang, Qiyao; Lai, Yiyi; Gu, Yong; Fang, Shuhuan; Chen, Huiling; Liu, Chenchen; Pan, Huafeng; Wu, Qihui; Fang, Jiansong

doi:10.1016/j.ejphar.2023.175895

Cited by 5 publications

(2 citation statements)

References 55 publications

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“…Zhuo and colleagues analyzed the 75% ethanol extract of AS root with the aid of ultra-high performance liquid chromatography coupled with quadrupoletime of flight-mass spectrometry. 66 The components of AS root included phenylpropanoids, flavonoids, organic acids, amino acids, carbohydrates and other types of compounds, similar to the categories identified in the AS leaf (ESI 2 †). Leaves are considered good alternative resources to roots or rhizomes, since their harvesting does not lead to plant death.…”

Section: Discussionmentioning

confidence: 65%

Metabolome and microbiome analyses of the anti-fatigue mechanism ofAcanthopanax senticosusleaves

Shi,

Liang,

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 65%

Metabolome and microbiome analyses of the anti-fatigue mechanism ofAcanthopanax senticosusleaves

Shi,

Liang,

et al. 2024

Food Funct.

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“…Peaks P1-5 were identified as CQAs with a molecular formula C16H18O9 by analyzing its protonated ion at m/z 355. Comparison with elution order and reference standards, peaks P1-4 were confirmed as 1-O-caffeoylquinic acid (1CQA), neochlorogenic acid (3CQA), chlorogenic acid (5CQA), and cryptochlorogenic acid (4CQA), respectively [27][28][29] . Peak P5 was their isomer and eluted after 5CQA.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities

Kwon,

Na,

Kim

et al. 2024

Preprint

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Acanthopanax senticosus belongs to Araliaceae family and is traditionally used as a tonic. The roots and stems are mainly used as a treatment for hypodynamia, rheumatism, and hypertension, but their frequent use may lead to its extinction. However, comprehensive and simultaneous analysis of the remaining parts were still limited, and needs to reorganize for standardization of functional foods. In this study, 50 phenolic compounds and 82 triterpenoid saponins from the shoots, leaves, fruits, and stems of A. senticosus were characterized using UPLC-QTOF-MS and UPLC-QTRAP-MS/MS. Among them, 57 new compounds were detected as the cis and malonyl-bound phenolic acids and were structural isomers of Acanthopanax flavonoids and saponins. All compounds were absolutely/relatively quantified, and shoots had the highest content. Antioxidant and α-glucosidase inhibitory activity were performed, followed by evaluation of structure-activity relationships. Both activities of all tested extracts and saponins showed remarkable efficacy and affected by the C-23 hydroxylation, the C-20(29) double bond, and the presence of rhamnose. These detailed profiling can be used as fundamental data for increasing the utilization of A. senticosus and developing them into functional foods.

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Exploring the pharmacological mechanisms of Biyan Qingdu Granula in the treatment after nasopharyngeal carcinoma radiotherapy based on UPLC/Q-TOF MS, network pharmacology and molecular docking

Yi,

Lv,

Zhang

et al. 2024

Journal of Pharmaceutical and Biomedical Analysis

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Systems pharmacology-based mechanism exploration of Acanthopanax senticosusin for Alzheimer's disease using UPLC-Q-TOF-MS, network analysis, and experimental validation

Cited by 5 publications

References 55 publications

Metabolome and microbiome analyses of the anti-fatigue mechanism ofAcanthopanax senticosusleaves

Metabolome and microbiome analyses of the anti-fatigue mechanism ofAcanthopanax senticosusleaves

Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities

Exploring the pharmacological mechanisms of Biyan Qingdu Granula in the treatment after nasopharyngeal carcinoma radiotherapy based on UPLC/Q-TOF MS, network pharmacology and molecular docking

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