Systolic flow displacement using 3D magnetic resonance imaging in an experimental model of ascending aorta aneurysm: impact of rheological factors

Ayaon-Albarrán, Ali; Fernández‐Jiménez, Rodrigo; Silva-Guisasola, Jacobo; Agüero, Jaume; Sánchez‐González, Javier; Galán‐Arriola, Carlos; Reguillo, Fernando del Rey; Castellanos, Luis Carlos Maroto; Ibáñez, Borja

doi:10.1093/ejcts/ezw132

Cited by 9 publications

(11 citation statements)

References 19 publications

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“…Eccentric systolic ow, displaced from the centerline toward the vessel wall, is one of a topic of clinical interest in exploring the role of rheology in the formation of ascending aortic aneurysm. Researchers have reported that stronger eccentric blood ow jet toward the aortic wall, which may include higher velocity, signi cant ow displacement and jet-to-wall impingement, lead to vascular remodeling and aneurysm formation [11,20,21]. Ayaon-Albarran et al [11] found aortic wall that was directly hit by eccentric ow jet were thinner, given that decreased thickness in vessel wall could result in aortic dissection.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers have reported that stronger eccentric blood ow jet toward the aortic wall, which may include higher velocity, signi cant ow displacement and jet-to-wall impingement, lead to vascular remodeling and aneurysm formation [11,20,21]. Ayaon-Albarran et al [11] found aortic wall that was directly hit by eccentric ow jet were thinner, given that decreased thickness in vessel wall could result in aortic dissection. Cebral et al [22,23] considered that a concentrated ow beam may cause an intracranial aneurysm to progress, and the decrease of the ow impingement size is more likely to cause aneurysm to experience growth or rupture than large impingement one.…”

Section: Discussionmentioning

confidence: 99%

“…Animal models have been successfully made to study the pathogenesis of aneurysm caused by aortic stenosis [9][10][11][12], effectively obtaining longitudinal features of aneurysm than from individuals. Models in pig [11] and our previous experiment in rat [12] showed that ascending aortic aneurysm could be induced by banding supra valvular of the ascending aortic. These models went through a chronic process which had a similarity to a certain extent with clinical ascending aorta aneurysm formation accompanied by aortic stenosis or BAV, indicating a delightful underlying clinical value.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Fluid-Structure Interaction Analysis on Influence of Banding Conditions to Ascending Aorta Aneurysm Formation in Rat

Su¹,

Fan²,

Tang³

et al. 2020

Preprint

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Background: Ascending aortic aneurysm in an important cause of mortality in cardiovascular diseases. Stenosis of aortic is considered to be a risk factor as the ascending aortic aneurysm grows. Animal models have been demonstrated that ascending aortic aneurysm could be induced by supra valvular banding of the ascending aortic. Our objective is to compare different banding conditions on the formation of aneurysms for more precise experiment and improving the preclinical value. Therefore, three comparison banding groups of banding altitude, banding severity and banding angle are established based on rat. Then flow pattern, wall shear stress (WSS) and vessel deformation of each model are calculated and discussed using transient two-way fluid-structure interaction (FSI) analysis in order to explore the influence of different banding methods on the generation of ascending aorta aneurysm.Results: Banding methods lead to different shapes or amplitudes of flow beam, WSS and vessel dilation. Eccentric flow beam, local high WSS accompany with vessel dilation are formed above the banding ring in all banding models because of the banding operation compared with normal model. More concentrated flow beam with bigger velocity, higher local WSS and more obvious expansion deformation above the banding ring are prone to happen in the middle segment banding with 60% banding severity and banding angle of 30 degree.Conclusion: According to the results, a higher position, relatively severe banding, and an acute banding angle are more favor to promote the generation of ascending aortic aneurysm.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative Fluid-Structure Interaction Analysis on Influence of Banding Conditions to Ascending Aorta Aneurysm Formation in Rat

Su¹,

Fan²,

Tang³

et al. 2020

Preprint

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“…As an advancement of 2D phase contrast MRI techniques (1), four-dimensional phase contrast (4D Flow) flow mapping has emerged as a rich source for assessment of hemodynamics (2)(3)(4). Post-processing of 4D Flow MRI allows measuring several quantitative features that characterize the secondary flow patterns in the aorta and pulmonary artery (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Turbulence, helical flow patterns, eccentricity and other secondary flow patterns are associated with many cardiovascular diseases (5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

MRI-based comprehensive analysis of vascular anatomy and hemodynamics

Gabbert¹,

Kheradvar²,

Jerosch‐Herold³

et al. 2021

Cardiovasc Diagn Ther

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Background: Standardized methods for mapping the complex blood flow in vessels are essential for processing the large data volume acquired from 4D Flow MRI. We present a method for systematic and efficient analysis of anatomy and flow in large human blood vessels. To attain the best outcomes in cardiac surgery, vascular modifications that lead to secondary flow patterns such as vortices should be avoided. In this work, attention was paid to the undesired cancelation of vortices with opposite directions of rotation, known as Dean flow patterns, using hemodynamic parameters such as circulation and helicity density.Methods: Our approach is based on the multiplanar reconstruction (MPR) of a multi-dimensional feature-space along the blood vessel's centerline. Hemodynamic parameters and anatomic information were determined in-plane from the reconstructed feature-space and from the blood vessel's centerline. A modified calculation of circulation and helicity density and novel parameters for quantifying Dean flow were developed. To test the model performance, we applied our methods to three test cases.Results: Comprehensive information on position, magnitude and interrelation of vascular anatomy and hemodynamics were extracted from 4D Flow MRI datasets. The results show that the Dean flow patterns can be efficiently assessed using the novel parameters.Conclusions: Our approach to comprehensively and simultaneously quantify multiple parameters of vascular anatomy and hemodynamics from 4D Flow MRI provides new insights to map complex hemodynamic conditions.

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“…For Objective 3. Supravalvular aortic stenosis was induced by emplacing a surgical banding on the ascending aorta, as was previously described [71][72][73]. Sedation was induced by intramuscular injection of ketamine (20 mg/kg), xylazine (2 mg/ kg) and midazolam (0.5 mg/kg), and then maintained with inhaled sevoflurane at 3% of concentration.…”

Section: Aortic Banding Surgerymentioning

confidence: 99%

New insights into anthracyline-induced cardiotoxicity

Arriola¹

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Gracias y mención especial a todo el personal administrativo y managers. Gracias Anabel, por ser la primera cara con la que me crucé por aquí cuando aún no sabía lo que se venía encima; gracias por quedarte hasta casi medianoche rellenando la PFIS, sin ti hoy no habría podido hacer la tesis. Gracias a Eeva por estar siempre ahí y lanzar una sonrisa a tiempo (que sirve más de lo que crees), gracias a Edu (Bieger) y a Sonia por su apoyo logístico y no tan logístico. Gracias a Víctor Bautista y a Ali Ayaon, por su apoyo al realizar los modelos quirúrgicos de esta tesis, sin los cuales se habría quedado a medio gas. Gracias al Dr. James McCully y a todos mis compañeros del laboratorio del Boston Children's Hospital: Arzoo, Alvise, Giovanna, Kamila, Caytlin, David y Dimitri. Gracias por enseñarme sobre el trasplante mitocondrial, así como formas diferentes de trabajar y por acompañarme durante mi estancia en una de las mejores experiencias de mi vida. Gracias a todos los que habéis pasado por aquí que, aunque lo creáis o no, habéis hecho mella y me habéis aportado algún granito de arena que otro: David, Juan, Dani, Chusa, Ramón y el inestimable número de cardiólogos del programa Res@CNIC, alumnos de prácticas, etc.Gracias a Manu y a José, por ayudar a abstraerme del estrés que supone una empresa de este calibre. Gracias por vuestra amistad. Si no he muerto en el intento es gracias a vosotros.Gracias a mi familia, a vosotros os dedico en especial esta tesis porque sois de los que más habéis sufrido sus consecuencias. A mis padres Estela y José Carlos y a mis hermanas Rebeca y Paloma: gracias por apoyarme en todas mis decisiones y por vuestro apoyo y amor incondicionales.

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Systolic flow displacement using 3D magnetic resonance imaging in an experimental model of ascending aorta aneurysm: impact of rheological factors

Cited by 9 publications

References 19 publications

Comparative Fluid-Structure Interaction Analysis on Influence of Banding Conditions to Ascending Aorta Aneurysm Formation in Rat

Comparative Fluid-Structure Interaction Analysis on Influence of Banding Conditions to Ascending Aorta Aneurysm Formation in Rat

MRI-based comprehensive analysis of vascular anatomy and hemodynamics

New insights into anthracyline-induced cardiotoxicity

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