Syzygium cumini (L.) Skeels., a novel therapeutic agent for diabetes: Folk medicinal and pharmacological evidences

Ayyanar, Muniappan; Subash-Babu, Pandurangan; Ignacimuthu, Savarimuthu

doi:10.1016/j.ctim.2013.03.004

Cited by 90 publications

(54 citation statements)

References 65 publications

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“…All parts of S. cumini tree, namely seeds, fruits, leaves, flower, and bark, are used in folklore medicine (Ayyanar et al, 2013;Saravanan & Pari, 2008). Pharmacological activities like chemoprotective, hypoglycaemic, hyperglycemic, analgesic, anti-inflammatory, anti-allergic, antihyperlipidemic, antiplaque, antimicrobial, antidiarrheal, anti-oxidant, gastroprotective, astringent to bowels, and antibacterial (Arun et al, 2011;Banerjee & Narendhirakannan, 2011;Bona et al, 2014;Brito et al, 2007;Helmstadter, 2007;Jadhav et al, 2009;Khan et al, 2011;Muruganandan et al, 2001;Rekha et al, 2010;Sharma et al, 2006) have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Aldose reductase and protein tyrosine phosphatase 1B inhibitory active compounds fromSyzygium cuminiseeds

Sawant

Singh

Dethe

et al. 2015

Pharmaceutical Biology

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Context: Syzygium cumini (L.) Skeels (Myrtaceae), commonly known as jamun, is an Indian plant, traditionally well known for its medicinal properties including antidiabetic activity. Objective: To isolate the antidiabetic compounds from Syzygium cumini seeds and evaluate their activity using aldose reductase (AR) and protein-tyrosine phosphatase 1B (PTP1B) inhibition assays. Materials and methods:The dried seeds were extracted with methanol and partitioned with ethyl acetate, butanol, and water. The extracts were screened for antidiabetic activity at a concentration of 100 mg/mL using in vitro AR and PTP 1B inhibition assays. Results and discussion: The highly enriched fractions obtained from broad ethyl acetate fraction yielded maslinic acid (1), 5-(hydroxymethyl) furfural (2), gallic acid (3), valoneic acid dilactone (4), rubuphenol (5), and ellagic acid (6). Structures were elucidated by 1 H-NMR and 13 C-NMR. The initial ethyl acetate fraction showed AR inhibitory activity with the IC 50 value of 2.50 mg/mL and PTP1B enzyme inhibition with the IC 50 value of 26.36 mg/mL. Compounds 3, 4, 5, and 6 were found to inhibit AR with IC 50 values of 0.77, 0.075, 0.165, and 0.12 mg/mL while the compounds 4, 5, and 6 inhibited PTP1B with IC 50 values of 9.37, 28.14, and 25.96 mg/mL, respectively. Conclusion:The results of this study demonstrate that the isolated constituents show promising in vitro antidiabetic activity and, therefore, can be candidates for in vivo biological screening using relevant models to ascertain their antidiabetic activity.

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Section: Introductionmentioning

confidence: 99%

Aldose reductase and protein tyrosine phosphatase 1B inhibitory active compounds fromSyzygium cuminiseeds

Sawant

Singh

Dethe

et al. 2015

Pharmaceutical Biology

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“…Jambul fruits resemble oblong or ovoid in shape. They have a single seed and a soft dark purple coloured almost black skin and a lighter purple flesh [2]. When eaten, the fruits coat the mouth and the tongue a deep purple colour that stays for a few hours.…”

Section: Introductionmentioning

confidence: 99%

“…It is very large tropical tree that belongs to Myrtaceae family and known by synonyms jambolan or black plum. In India, the jamun tree and its fruit are known variously as Jamun, Jambul, Jaamoon, Jambul [1]. Worldwide, it is known by some other names like Java Plum, Black Plum, Indian blackberry, Portuguese Plum, Jambolan Plum etc.…”

Section: Introductionmentioning

confidence: 99%

Development and Effects of Jamun Seed Powder Incorporated Cookies

2016

IJSR

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The present study was to formulate the jamun seed powder incorporated cookies by incorporation of different level of jamun seed powder like 5%, 10% and 15% into cookies. The Organoleptic properties of the formulated cookies like colour, appearance, flavour, viscosity, taste and over all acceptability were evaluated. Among the different incorporation 10% of jamun seed powder incorporated cookies were recorded the highest scores for overall acceptability.

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“…Syzygium cumini L. Skeels, of the Myrtaceae family, popularly known as jamun, is included in the List of Medicinal Plants of Interest to the Public Health System (Renisus), issued by the Ministry of Health, which includes plants with potential use for medicines (Souza, 2005;Brasil, 2009;Swami, 2012;Subash-Babu and Ayyanar et al, 2013). All parts of S. cumini are widely used as traditional medicine, for example, juice of tender leaves is given in goat milk to treat diarrhoea in children (Morton, 1963;Corrêa, 1974;Lainetti and Brito, 1979;Nadkarni, 1976).…”

Section: Introductionmentioning

confidence: 99%

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

Monteiro¹,

Carvalho²,

Marques³

et al. 2018

Afr. J. Pharm. Pharmacol.

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Syzygium cumini L. Skeels (Myrtaceae) commonly known as jambolan is used as traditional medicine to treat gastrointestinal disorders in children in Brazil. This work is one of the first to evaluate the antidiarrhoeal and antispasmodic activity of the standardized extract of S. cumini leaves (HESc) in experimental models in vitro and in vivo rodents. Mice pre-treated with HESc (100, 250 and 1000 mg/kg) and atropine (1.0 mg/kg) had reduced intestinal transit velocity of 11.0; 23.2 and19.1%, respectively compared to saline control (46.6±0.9). In isolated rats jejunum, HESc (50, 150 and 300 µg/mL) shifted to the right cumulative concentration-response curves to ACh with changing maximum effect (E max ), which is characteristic of non-competitive antagonism to ACh. HESc also promoted relaxation (E max 90.2±5.8%) in preparations pre-contacted with KCl (75 mM). Additionally, it reduced the maximal CaCl 2 -induced response in 15.4; 56.3 and 92.1% in a concentration-dependent manner. The study results show that HESc has an antidiarrhoeal and spasmolytic potential that can be partly explained by the reduction of intestinal transit velocity and blockage of the voltage-dependent calcium channels in the smooth intestinal muscle.

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Syzygium cumini (L.) Skeels., a novel therapeutic agent for diabetes: Folk medicinal and pharmacological evidences

Cited by 90 publications

References 65 publications

Aldose reductase and protein tyrosine phosphatase 1B inhibitory active compounds fromSyzygium cuminiseeds

Aldose reductase and protein tyrosine phosphatase 1B inhibitory active compounds fromSyzygium cuminiseeds

Development and Effects of Jamun Seed Powder Incorporated Cookies

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

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