1991
DOI: 10.1016/0165-4608(91)90117-d
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t(16;21)(p11.2;q22): A recurrent primary rearrangement in ANLL

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Cited by 18 publications
(15 citation statements)
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“…This result suggested that the fusion transcript was formed with the 5' portion of the ERG gene and the 3' portion of an unknown gene on chromosome 16, although it might have been formed by alternative splicing of the ERG gene, which was activated during the malignant transformation. On the other hand, with the probe of the 3' region, considerable amounts of two transcripts of 5 detected. Although these were almost the same sizes as those observed in Kasumi-1 and MOLT-4, they should not be the normal transcripts, because the intensities of their bands were much higher than those detected with the probe of the 5' region.…”
Section: Methodsmentioning
confidence: 99%
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“…This result suggested that the fusion transcript was formed with the 5' portion of the ERG gene and the 3' portion of an unknown gene on chromosome 16, although it might have been formed by alternative splicing of the ERG gene, which was activated during the malignant transformation. On the other hand, with the probe of the 3' region, considerable amounts of two transcripts of 5 detected. Although these were almost the same sizes as those observed in Kasumi-1 and MOLT-4, they should not be the normal transcripts, because the intensities of their bands were much higher than those detected with the probe of the 5' region.…”
Section: Methodsmentioning
confidence: 99%
“…3). Southern blot analysis of BamHIdigested genomic DNA from the somatic cell hybrid NSC532, containing the der(16) chromosome from patient 1, and from peripheral blood cells of three t(16;21) patients (patients [3][4][5] revealed that the t(16;21) breakpoints were clustered within a limited region. The sample ofpatient 2 was not sufficient for this analysis.…”
Section: Methodsmentioning
confidence: 99%
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“…As the prognosis of this type of leukemia has been reported to be considerably poor [1, 7], we treated the patient with high-dose chemotherapy plus allogeneic BMT. Although the TLS/FUS-ERG fusion transcripts were not observed in pre-BMT remission phase, they became clearly detectable 6 months after transplantation, which was followed by hematological relapse.…”
Section: Discussionmentioning
confidence: 99%
“…Although most of the AML patients with t(16;21)(p11;q22) achieve complete remission, it generally is not maintained [1, 7]. Consequently, the median survival was reported to be only 16 months [1].…”
Section: Introductionmentioning
confidence: 99%