T cell and eosinophil activation in mild and moderate atopic and nonatopic children's asthma in remission

Abstract

Changes in the concentration of sIL-2R, IL-2 and ECP reflect increased T cell and eosinophil activity in relation to the level of severity of asthma in atopic and nonatopic children, thereby proving the presence of persistent inflammation despite the absence of disease symptoms.

Soluble immune receptor serum levels are associated with age, but not with clinical phenotype or disease severity in childhood atopic dermatitis

“…On the contrary, all SIRs were detected at highly similar concentrations showing analogue mutual correlations in both groups, which imply that SIRs cannot be employed as in vitro differentiators between the extrinsic and intrinsic phenotype of AD in childhood. While corresponding investigations of similar design have hitherto not been performed in the context of AD, our data are in conflict with a recent study suggesting significantly higher sCD25 levels in children with extrinsic asthma compared with those with intrinsic, non‐atopic asthma 10 . However, these results have to be interpreted with caution, because other investigators inversely reported lower sCD25 levels in extrinsic asthma or no differential SIR regulation at all 9,11 …”

“…While corresponding investigations of similar design have hitherto not been performed in the context of AD, our data are in conflict with a recent study suggesting significantly higher sCD25 levels in children with extrinsic asthma compared with those with intrinsic, non-atopic asthma. 10 However, these results have to be interpreted with caution, because other investigators inversely reported lower sCD25 levels in extrinsic asthma or no differential SIR regulation at all. 9,11 Correlation of SIR levels with AD severity…”

“…Likewise, the soluble α‐chain of the interleukin‐2 receptor (sIL2RA, sCD25) has been shown to be associated with the expansion and apoptosis of T lymphocytes, particularly T regs , and has been discussed as a serological indicator of immune activation in children and adults with asthma 9–11 . Moreover, the low‐affinity IgE receptor (FcεRII, CD23) has been implicated in IgE homeostasis, and elevated soluble CD23 (sCD23) levels have been reported previously in patients with allergic diseases 12 .…”

“…[4][5][6][7][8] Likewise, the soluble a-chain of the interleukin-2 receptor (sIL2RA, sCD25) has been shown to be associated with the expansion and apoptosis of T lymphocytes, particularly T regs , and has been discussed as a serological indicator of immune activation in children and adults with asthma. [9][10][11] Moreover, the low-affinity IgE receptor (FceRII, CD23) has been implicated in IgE homeostasis, and elevated soluble CD23 (sCD23) levels have been reported previously in patients with allergic diseases. 12 In contrast, the soluble pattern recognition receptor sCD14 was found to be downregulated in symptomatic children with atopy, but upregulated during acute exacerbations in children with bronchial asthma.…”

CD4+CD25high Treg cells in peripheral blood during remission and exacerbation of allergic asthma in children

“…In our study, IL‐2 concentration was increased in the serum of asthmatic children in disease remission and exacerbation as compared with controls. The results suggest T‐cell activation as one of the characteristics of persistent inflammation in asthma as was shown in our previous study (24). However, no correlation was found between IL‐2 and CD4 + CD25 high T‐cell percentages in asthma remission as well as in exacerbation.…”