T-cell and NK-cell neoplasms of the gastrointestinal tract – recurrent themes, but clinical and biological distinctions exist

Jaffe, Elaine S.

doi:10.3324/haematol.2020.252924

Cited by 8 publications

(6 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…7 Novel immunophenotypic and genomic data reinforce their distinction. 224 Expression of SYK is absent in EATL. 225 Most patients with EATL are T-cell receptor (TCR)-silent, whereas most patients with MEITL express the TCR and derive more frequently from gamma-delta T cells than from alpha-beta T cells.…”

Section: Extranodal T-cell and Nk-cell Neoplasms Involving The Gastro...mentioning

confidence: 98%

The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

Campo

Jaffe

Cook

et al. 2022

Blood

Self Cite

813

575

View full text Add to dashboard Cite

Since the publication of the Revised European-American Classification of mature lymphoid neoplasms in 1994, subsequent updates of the classification of mature lymphoid neoplasms have been generated through iterative international efforts to achieve broad consensus among hematopathologists, geneticists, molecular scientists, and clinicians. Significant progress in the characterization of malignancies of the immune system in the last years, with many new insights provided by genomic studies, have led to the current proposal. We have followed the same process that was successfully used for the 3rd and 4th editions of the WHO classification of hematological neoplasms. The definition, recommended studies, and criteria for the diagnosis of many entities have been extensively refined. Some categories considered provisional are now upgraded to definite entities. Terminology of some diseases has been revised to adapt nomenclature to the current knowledge of their biology, but these modifications have been restricted to well-justified situations. Major findings from recent genomic studies have impacted the conceptual framework and diagnostic criteria for many disease entities. These changes will have an impact on optimal clinical management. The conclusions of this work are summarized in this report as the proposed International Consensus Classification (ICC) of mature lymphoid, histiocytic, and dendritic cell tumors.

show abstract

Section: Extranodal T-cell and Nk-cell Neoplasms Involving The Gastro...mentioning

confidence: 98%

The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

Campo

Jaffe

Cook

et al. 2022

Blood

Self Cite

813

575

View full text Add to dashboard Cite

show abstract

“…The distinction between EATL and MEITL has been further refined by means of genomic studies 39 (Table 3). In particular, the T‐cell receptor (TCR) is silent in most EATL patients whilst it is expressed in the majority of MEITL cases that derive more frequently from gamma‐delta T‐cells than from alpha‐beta T‐cells 40–44 .…”

Section: Mature T‐cell and Nk‐cell Neoplasmsmentioning

confidence: 99%

A comparison of the International Consensus and 5th WHO classifications of T‐cell lymphomas and histiocytic/dendritic cell tumours

Falini¹,

Pileri

2023

Br J Haematol

View full text Add to dashboard Cite

SummarySince the publication in 2017 of the revised 4th Edition of the World Health Organization (WHO) classification of haematolymphoid tumours, here referred to as WHO‐HAEM4, significant clinicopathological, immunophenotypic and molecular advances have been made in the field of lymphomas, contributing to refining the diagnostic criteria of several diseases, upgrading entities previously defined as provisional and identifying new entities. This process has resulted in two recent classification proposals of lymphoid neoplasms: the International Consensus Classification (ICC) and the 5th edition of the WHO classification (WHO‐HAEM5). In this paper, we review and compare the two classifications in terms of diagnostic criteria and entity definition, focusing on T‐cell lymphomas and histiocytic/dendritic cell tumours. Moreover, we update the genetic data of the various pathological entities. The main goal is to provide a tool to facilitate the work of the pathologists, haematologists and researchers involved in the diagnosis and treatment of these haematological malignancies.

show abstract

“…%40 vakada, hemofagositik sendrom ile birlikteliği görülebilir. Mezenterik lenf nodları, kemik iliği, akciğer, mediasten, karaciğer, deri ve nadiren santral sinir sitemine yayılım gösterebilir 36,37 Histolojik olarak EBVMCU, iyi sınırlı ülsere lezyonlardır. Ülser kenarında, polimorfik, subepitelyal lenfoid infiltrat görünür ( Resim 8A).…”

Section: şEkil 2 Hans Algoritması 28unclassified

Gastrointestinal sistem lenfoproliferatif lezyonlara pratik yaklaşım

TOYRAN

2022

Arşiv Kaynak Tarama Dergisi

View full text Add to dashboard Cite

The gastrointestinal tract is the primary localization site of lymphoproliferative lesions ranging from reactive lymphoid hyperplasia to lymphoma. Diagnosis of these diseases is difficult, especially in small endoscopic biopsies. And integrated approach based on clinical, morphological, immunohistochemical and molecular data is needed for accurate diagnosis. In this review, the basic histological features of non-Hodgkin lymphomas in the gastrointestinal tract and the entities included in the differential diagnosis are discussed.

show abstract

T-cell and NK-cell neoplasms of the gastrointestinal tract – recurrent themes, but clinical and biological distinctions exist

Cited by 8 publications

References 38 publications

The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

A comparison of the International Consensus and 5th WHO classifications of T‐cell lymphomas and histiocytic/dendritic cell tumours

Gastrointestinal sistem lenfoproliferatif lezyonlara pratik yaklaşım

Contact Info

Product

Resources

About