T-cell immunity and cytokine production in cosmonauts after long-duration space flights

Моруков, Б. В.; Рыкова, М. П.; Антропова, Е. Н.; Berendeeva, T. A.; Ponomaryov, S.; Larina, I. M.

doi:10.1016/j.actaastro.2010.08.036

Cited by 27 publications

(13 citation statements)

References 19 publications

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“…In a study investigating spaceflight effects on the immune system in 30 cosmonauts, striking alterations in immune responses during and after space flight were observed, including a reduced percentage of NK, as well as suppressed NK activity by up to 85% relative to pre-flight (Rykova et al 2008). Similar findings were reported in a study on long-duration spaceflight by 12 Russian cosmonauts, which included significantly suppressed T-cell immunity and exaggerated cytokine production after landing relative to before launch (Morukov et al 2011). Moreover, alterations in the endocannabinoid system (ECS), which is known to play an important role in the regulation of various physiological functions, including stress regulation, behavior, mood, memory, vegetative control, and immunity, were observed following time on board of the International Space Station (ISS), resulting in an increase in circulating endocannabinoids (Strewe et al 2012).…”

Section: From Daily Life To Space Travelsupporting

confidence: 73%

“…In light of these results, full characterization of the shifts in the innate and adaptive immune system after space travel (see Chaps. 11-15) is critical to understand the relationship between microgravity and the stress effects of space flight in human space explorers (Morukov et al 2011). In turn, studies of stressors encountered in space travel might also advance our understanding of stress in our daily lives.…”

Section: From Daily Life To Space Travelmentioning

confidence: 99%

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The Impact of Everyday Stressors on the Immune System and Health

Seiler

Fagundes

Christian

2019

Stress Challenges and Immunity in Space

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Section: From Daily Life To Space Travelsupporting

confidence: 73%

Section: From Daily Life To Space Travelmentioning

confidence: 99%

The Impact of Everyday Stressors on the Immune System and Health

Seiler

Fagundes

Christian

2019

Stress Challenges and Immunity in Space

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“…Astronauts are subjected to increased radiation, microgravity and persistent fluids shifts, prolonged isolation and confinement, circadian shifts that are difficult to re-entrain, with complicated work tasks and schedules. Immune system dysregulation has now been demonstrated to occur during flight and persist during 6-month orbital spaceflight ( 13 , 15 – 18 ). The phenomenon typically occurs concurrently with persistent reactivation and shedding of latent herpesviruses.…”

Section: Spaceflight and The Immune Systemmentioning

confidence: 99%

Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions

et al. 2018

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Recent studies have established that dysregulation of the human immune system and the reactivation of latent herpesviruses persists for the duration of a 6-month orbital spaceflight. It appears certain aspects of adaptive immunity are dysregulated during flight, yet some aspects of innate immunity are heightened. Interaction between adaptive and innate immunity also seems to be altered. Some crews experience persistent hypersensitivity reactions during flight. This phenomenon may, in synergy with extended duration and galactic radiation exposure, increase specific crew clinical risks during deep space exploration missions. The clinical challenge is based upon both the frequency of these phenomena in multiple crewmembers during low earth orbit missions and the inability to predict which specific individual crewmembers will experience these changes. Thus, a general countermeasure approach that offers the broadest possible coverage is needed. The vehicles, architecture, and mission profiles to enable such voyages are now under development. These include deployment and use of a cis-Lunar station (mid 2020s) with possible Moon surface operations, to be followed by multiple Mars flyby missions, and eventual human Mars surface exploration. Current ISS studies will continue to characterize physiological dysregulation associated with prolonged orbital spaceflight. However, sufficient information exists to begin consideration of both the need for, and nature of, specific immune countermeasures to ensure astronaut health. This article will review relevant in-place operational countermeasures onboard ISS and discuss a myriad of potential immune countermeasures for exploration missions. Discussion points include nutritional supplementation and functional foods, exercise and immunity, pharmacological options, the relationship between bone and immune countermeasures, and vaccination to mitigate herpes (and possibly other) virus risks. As the immune system has sentinel connectivity within every other physiological system, translational effects must be considered for all potential immune countermeasures. Finally, we shall discuss immune countermeasures in the context of their individualized implementation or precision medicine, based on crewmember specific immunological biases.

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“…Furthermore, interleukin-2, which is a biomarker for T cell activity, was found to be decreased after spaceflight for both helper and cytotoxic T cells [ 52 ,62]. Activation response of T cells to stimulating agents such as phytohemagglutinin was also found to be diminished as a result of spaceflight [62,63]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Spaceflight on Cells of Bone Marrow Origin

Özçivici¹

2013

tjh

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Once only a subject for science fiction novels, plans for establishing habitation on space stations, the Moon, and distant planets now appear among the short-term goals of space agencies. This article reviews studies that present biomedical issues that appear to challenge humankind for long-term spaceflights. With particularly focus on cells of bone marrow origin, studies involving changes in bone, immune, and red blood cell populations and their functions due to extended weightlessness were reviewed. Furthermore, effects of mechanical disuse on primitive stem cells that reside in the bone marrow were also included in this review. Novel biomedical solutions using space biotechnology will be required in order to achieve the goal of space exploration without compromising the functions of bone marrow, as spaceflight appears to disrupt homeostasis for all given cell types. Conflict of interest:None declared.

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T-cell immunity and cytokine production in cosmonauts after long-duration space flights

Cited by 27 publications

References 19 publications

The Impact of Everyday Stressors on the Immune System and Health

The Impact of Everyday Stressors on the Immune System and Health

Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions

Effects of Spaceflight on Cells of Bone Marrow Origin

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