T-cell immunity in the aging human

Pawelec, Graham

doi:10.3324/haematol.2013.094383

Cited by 34 publications

(21 citation statements)

References 15 publications

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“…The increased proportion of memory T cells in aged humans exemplifies the complex mechanisms that underlie many of the age-related immune alterations (Pawelec 2014). The shift from a population of predominantly naïve T cells to a population of predominantly memory T cells reflects the influence of cumulative exposure to foreign antigens/pathogens over time.…”

Section: Discussionmentioning

confidence: 99%

“…The CD4/CD8 ratio averaged 2 in the three groups; there were rare individuals who exhibited an inverted ratio (<1.0), one of the parameters of the immune risk profile (Ferguson et al 1995;Strindhall et al 2013). Other age-related changes include the decrease in the pool of antigeninexperienced (naïve) T cells and the concomitant increase in the number of antigen-experienced (memory) T cells, which has been linked to the loss of immunological efficiency of the aged immune system (Pawelec 2014). Antigen-experienced cells can be further divided into central memory (T CM ), effector memory (T EM ), and effector memory cells that re-express CD45RA (T EMRA ) according to their expression of the tyrosine phosphatase isoform CD45RA and the chemokine receptor CCR7 .…”

Section: T Lymphocyte Subpopulationsmentioning

confidence: 99%

“…Aging-related changes that affect the competence of the i m m u n e s y s t e m a r e d e f i n e d b y t h e t e r m immunosenescence (Pawelec 2014). The decline of the immune system with age is reflected by increased frequencies of infection, cancer, cardiovascular disease, and neurodegenerative disease (Sarkar and Fisher 2006;Targonski et al 2007;Yu et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations

Silva

Araújo

Fernandes

et al. 2016

AGE

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Studies indicate that exercise might delay human biological aging, but the effects of long-term exercise on T cell function are not well known. We tested the hypothesis that moderate or intense exercise lifestyle may attenuate the effects of aging on the telomere length and the survival and composition of T cell subpopulations. Elderly (65-85 years) with intense training lifestyle (IT, n = 15), moderate training lifestyle (MT, n = 16), and who never trained (NT, n = 15) were studied. Although the three groups presented the ageassociated contraction of the TCD4 + /TCD8 + naïve compartments and expansion of the memory compartments, both training modalities were associated with lower proportion of terminally differentiated (CD45RA + CCR7 neg ) TCD4 + and TCD8 + cells, although among the latter cells, the reduction reached statistical significance only with IT. MT was associated with higher proportion of central memory TCD4 + cells, while IT was associated with higher proportion of effector memory TCD8 + cells. However, both training lifestyles were unable to modify the proportion of senescent (CD28 neg ) TCD8 + cells. Telomeres were longer in T cells in both training groups; with IT, telomere length increased mainly in TCD8 + cells, whereas with MT, a modest increase in telomere length was observed in both TCD8 + and TCD4 + cells. Reduced commitment to apoptosis of resting T cells, as assessed by caspase-3 and Bcl-2 expression, was seen predominantly with IT.

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Section: Discussionmentioning

confidence: 99%

Section: T Lymphocyte Subpopulationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations

Silva

Araújo

Fernandes

et al. 2016

AGE

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“…The redistribution of T-cell phenotypes from naïve predominant to memory-enriched after CMV infection occurs rapidly. 36 Viral latency drives inflation of memory cells, and is considered a hallmark of CMV infection. 37 Numerous data have pinpointed the requirement for the host to maintain control of latent CMV infection throughout life.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus shapes long-term immune reconstitution after allogeneic stem cell transplantation

et al. 2014

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Immune reconstitution after allogeneic stem cell transplantation is a dynamic and complex process depending on the recipient and donor characteristics, on the modalities of transplantation, and on the occurrence of graft-versushost disease. Multivariate methods widely used for gene expression profiling can simultaneously analyze the patterns of a great number of biological variables on a heterogeneous set of patients. Here we use these methods on flow cytometry assessment of up to 25 lymphocyte populations to analyze the global pattern of long-term immune reconstitution after transplantation. Immune patterns were most distinct from healthy controls at six months, and had not yet fully recovered as long as two years after transplant. The two principal determinants of variability were linked to the balance of B and CD8 + T cells and of natural killer and B cells, respectively. Recipient's cytomegalovirus serostatus, cytomegalovirus replication, and chronic graft-versus-host disease were the main factors shaping the immune pattern one year after transplant. We identified a complex signature of underand over-representation of immune populations dictated by recipient's cytomegalovirus seropositivity. Finally, we identified dimensions of variance in immune patterns as significant predictors of long-term non-relapse mortality, independently of chronic graft-versus-host disease.

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“…One possible source of this endogenous "noise" is the senescence-associated secretory phenotype (SASP) characterizing the accumulating "senescent" cells in the elderly that can affect the behavior of neighboring cells (Coppe et al, 2010;Rodier and Campisi, 2011). The SASP is a spectrum of proinflammatory proteins and cytokines secreted by such cells which have permanently exited the cell cycle and are known to accumulate in the periphery to significant numbers with advancing age (Pawelec, 2014b;Tchkonia et al, 2013). This process is also associated with the activation of self-reactive memory B cells, producing increased levels of autoantibodies (Fig.…”

Section: "Inflammaging" and Age-related Autoimmunitymentioning

confidence: 99%

As we age: Does slippage of quality control in the immune system lead to collateral damage?

Müller

Pawelec

2015

Ageing Research Reviews

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T-cell immunity in the aging human

Cited by 34 publications

References 15 publications

Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations

Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations

Cytomegalovirus shapes long-term immune reconstitution after allogeneic stem cell transplantation

As we age: Does slippage of quality control in the immune system lead to collateral damage?

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