2017
DOI: 10.1039/c6ib00233a
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T cell immunoengineering with advanced biomaterials

Abstract: Biomaterial interfaces can present soluble and physical cues on the nano- and micro-scale to control T cell behaviour.

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Cited by 29 publications
(18 citation statements)
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“…Inflammatory markers, Interleukin-2 (IL-2) and Interferon gamma (IFN-y), were absent in both the PADM and human acellular dermal matrix group up to 48 hours postimplantation. 37 These are produced by antigen-sensitized T-cells in the context of foreign body rejection, 38 suggesting both were well tolerated. There may be a role for biopsy during a single-stage ADM breast reconstruction to ascertain local tissue inflammation through definitive histological analysis.…”
Section: Discussionmentioning
confidence: 99%
“…Inflammatory markers, Interleukin-2 (IL-2) and Interferon gamma (IFN-y), were absent in both the PADM and human acellular dermal matrix group up to 48 hours postimplantation. 37 These are produced by antigen-sensitized T-cells in the context of foreign body rejection, 38 suggesting both were well tolerated. There may be a role for biopsy during a single-stage ADM breast reconstruction to ascertain local tissue inflammation through definitive histological analysis.…”
Section: Discussionmentioning
confidence: 99%
“…Although the lymphocytes are attempted to be preserved under proper conditions during in vitro manipulation, they inevitably encounter external stresses, such as centrifugation, malnutrition, and temperature fluctuation, which leads to unwanted cell death and loss . Moreover, it is often required to engineer lymphocytes (and other therapeutically functional cells) under non‐biological conditions in chemical and electromechanical devices, but fragility of mammalian cells is one of the hurdles in in vitro manipulation. It is highly challenging and costly to maintain the cell viability and protect the cells from outside aggressors in vitro during the manipulation, handling, and storage of mammalian cells.…”
Section: Figurementioning
confidence: 99%
“…In cell therapy, cell preservation under non‐culture conditions is crucial in the handling and storage of the cells . The cells should remain alive even under harmful external stresses.…”
Section: Figurementioning
confidence: 99%
“…Although the lymphocytes are attempted to be preserved under proper conditions during in vitro manipulation, they inevitably encounter external stresses,s uch as centrifugation, malnutrition, and temperature fluctuation, which leads to unwanted cell death and loss. [6] Moreover,itis often required to engineer lymphocytes (and other therapeutically functional cells) under non-biological conditions in chemical and electromechanical devices, [7] but fragility of mammalian cells is one of the hurdles in in vitro manipulation. It is highly challenging and costly to maintain the cell viability and protect the cells from outside aggressors in vitro during the manipulation, handling, and storage of mammalian cells.…”
mentioning
confidence: 99%
“…In cell therapy,c ell preservation under non-culture conditions is crucial in the handling and storage of the cells. [7] Thec ells should remain alive even under harmful external stresses.I nt his respect, we investigated the longterm viability of Jurkat@TiO 2 (Figure 3a). Native Jurkat or Jurkat@TiO 2 cells were suspended in serum-free RPMI 1640 medium at 25 8 8Ci naw ater bath (not in aC O 2 incubator).…”
mentioning
confidence: 99%