T‐cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer

Fathi, Mehrdad; Pustokhina, Inna; Kuznetsov, S.V.; Khayrullin, Mars; Hojjat‐Farsangi, Mohammad; Karpisheh, Vahid; Jalili, Ali; Jadidi‐Niaragh, Farhad

doi:10.1002/iub.2461

Cited by 34 publications

(15 citation statements)

References 136 publications

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“…Meanwhile, PIGR had a negative correlation with tumor-infiltrating NK cells and Tcm cells. Studies have demonstrated that immune checkpoint inhibitors have been regarded as potential strategies for enhancing immune responses in patients with CRC [ 42 ]. We found that the expression of PIGR had a positive relationship with several immune checkpoints, including IDO1, CD274, PDCD1, CTLA4, and LAG3.…”

Section: Discussionmentioning

confidence: 99%

The Underlying Roles of Exosome-Associated PIGR in Fatty Acid Metabolism and Immune Signaling in Colorectal Cancer

Liu

Deng

2022

Journal of Oncology

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The polymeric immunoglobulin receptor (PIGR), an exosome-associated glycoprotein, plays an important role in the occurrence and development of different tumors. This study aimed to investigate whether PIGR is essential for colorectal cancer (CRC). Comprehensive bioinformatics analysis and immunohistochemistry (IHC) revealed that expression of PIGR was significantly decreased in CRC patients. Upregulated PIGR displayed favorable prognostic values in CRC patients. Several algorithms, such as TISIDB and TIMER, were used to evaluate the roles of PIGR expression in the regulation of immune response in CRC. Moreover, GSEA enrichment analysis indicated the underlying role of PIGR in the regulation of fatty acid metabolism in CRC. Taken together, our findings might provide a new potential prognostic and immune-associated biomarker for CRC and supply a new destination for PIGR-related immunotherapy in clinical treatment.

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Section: Discussionmentioning

confidence: 99%

The Underlying Roles of Exosome-Associated PIGR in Fatty Acid Metabolism and Immune Signaling in Colorectal Cancer

Liu

Deng

2022

Journal of Oncology

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“…Vascular endothelial cells, nonmalignant cells, immunocytes, tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), myeloid-derived suppressor cells (MDSCs), natural killer (NK) cells, dendritic cells (DCs) and tumor-associated neutrophils (TANs) make up the tumor microenvironment (TME) ( 44 , 45 ). TIGIT was highly positively correlated with the ESTIMATE score in all of the cancers included, which indicated an advanced cancer stage with a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of TIGIT in East Asian patients with solid cancers: A systematic review, meta-analysis and pancancer analysis

Pan

et al. 2022

Front. Immunol.

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BackgroundT-cell immunoreceptor with Ig and ITIM domains (TIGIT) participates in tumor immune escape by delivering inhibitory signals to T cells. The purpose of this article was to assess the prognostic value of TIGIT and its immunological function in solid cancers.MethodsThree databases were searched for relevant articles. The main endpoints were overall survival (OS), progression-free survival (PFS), recurrence-free survival (RFS), and disease-free survival (DFS). Hazard ratios (HR) were pooled by using fixed-effects or random-effects models. Pancancer analysis of TIGIT was performed based on public online databases, mainly The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and UCSC Xena. The possible relationships between TIGIT expression and the tumor microenvironment (TME), infiltration of immune cells, immune-related genes, tumor mutation burden (TMB), and microsatellite instability (MSI) were revealed in this article.ResultsSixteen studies met the inclusion criteria. High expression of TIGIT was associated with worse OS [HR= 1.73, 95% confidence interval (CI) 1.50, 1.99], PFS (HR = 1.53, 95% CI [1.25, 1.88]), RFS (HR = 2.40, 95% CI [1.97, 2.93]), and DFS (HR= 6.57, 95% CI [0.73, 59.16]) in East Asian patients with solid cancers. TIGIT expression was positively correlated with immune infiltration scores and infiltration of CD8 T lymphocytes in all of the cancers included. TIGIT was found to be coexpressed with the genes encoding immunostimulators, immunoinhibitors, chemokines, chemokine receptors, and major histocompatibility complex (MHC), especially in gastroesophageal cancer. TMB and MSI were also associated with TIGIT upregulation in diverse kinds of cancers.ConclusionHigh expression of TIGIT is associated with poorer prognosis in East Asian patients with solid cancers. TIGIT is a novel prognostic biomarker and immunotherapeutic target for various solid cancers because of its activity in cancer immunity and tumorigenesis.

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“…These ligands primarily initiate the inhibitory signal through affecting the cytoplasmic domain and the immunoreceptor tyrosine-based inhibition motif (ITIM) after binding to TIGIT. 30 Fap2 protein has been found to be involved in the binding of F.n to cancer cells and can interact directly with TIGIT which is mainly expressed on NK, Treg, CD8 + and CD4 + T cells. 31 The binding of Fap2 to TIGIT can thereafter inhibit the activity of NK cells against tumor cells which can lead to the growth and progression of CRC.…”

Section: Mechanisms Through Which Fn Can Promote Crcmentioning

confidence: 99%

Fusobacterium nucleatum and Colorectal Cancer

Li¹,

Shen²,

Xu³

2022

IDR

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Fusobacterium nucleatum ( F.n ) is an oral anaerobic gram-negative bacillus that can colonize into the colon tissues through bloodstream infection. F.n have been found to be involved in both the occurrence and metastasis of colorectal cancer (CRC) through regulating immune response, virulence factor, oncogenic microRNAs, intestinal metabolites, DNA damage and other mechanisms. Therefore, F.n can be as an important pathogenic risk factor and a possible biomarker of CRC. Based on this, we have summarized the potential relationship between F.n and CRC to provide reference for the targeted therapy of CRC.

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T‐cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer

Cited by 34 publications

References 136 publications

The Underlying Roles of Exosome-Associated PIGR in Fatty Acid Metabolism and Immune Signaling in Colorectal Cancer

The Underlying Roles of Exosome-Associated PIGR in Fatty Acid Metabolism and Immune Signaling in Colorectal Cancer

Prognostic value of TIGIT in East Asian patients with solid cancers: A systematic review, meta-analysis and pancancer analysis

Fusobacterium nucleatum and Colorectal Cancer

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