2010
DOI: 10.1053/j.gastro.2010.07.003
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T-Cell Immunoglobulin Mucin-3 Determines Severity of Liver Ischemia/Reperfusion Injury in Mice in a TLR4-Dependent Manner

Abstract: The newly discovered T-cell immunoglobulin mucin (TIM) gene family molecules, expressed by T cells, regulate host immunity and tolerance. Although CD4+ T cells mediate innate immunity-dominated liver ischemia-reperfusion injury (IRI), the underlying mechanisms remain obscure. We have recently documented the novel function of TIM-1 pathway in the mechanism of liver IRI and also found that TLR4 activation plays a key triggering role. Using an anti-TIM-3 Ab, we now studied the role of TIM-3 signaling in the model… Show more

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Cited by 108 publications
(116 citation statements)
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“…Consistent with previous studies (12,20) wt mice undergoing 90 min of warm partial IRI featured signs (increased ALT and hepatocellular necrosis) of hepatic injury 24 h after reperfusion (data not shown). Gr-1-immunohistochemistry (IHC) and MPO results showed massive infiltration of neutrophils in the necrotic liver areas (data not shown).…”
Section: Unconventional T Cells Are the Major Il-17-producing Cells Isupporting
confidence: 92%
“…Consistent with previous studies (12,20) wt mice undergoing 90 min of warm partial IRI featured signs (increased ALT and hepatocellular necrosis) of hepatic injury 24 h after reperfusion (data not shown). Gr-1-immunohistochemistry (IHC) and MPO results showed massive infiltration of neutrophils in the necrotic liver areas (data not shown).…”
Section: Unconventional T Cells Are the Major Il-17-producing Cells Isupporting
confidence: 92%
“…The induction of proinflammatory cytokine and chemokine programs was also blunted, data supported by findings from a renal I/R injury mouse model (Rong et al 2011). The TIM-3 -Gal-9, on the other hand, constitutes a "negative" T-cell costimulation signal, as TIM-3 blockade worsens tissue damage, along with increased IFN-g and reciprocally depressed IL-10 expression in I/Rstressed organs (Uchida et al 2010b). The PD-1 (B7)-PD-L1 (H1) "negative" T-cell pathway has been also shown to promote I/R cytoprotection (Ji et al 2010;Ueki et al 2011).…”
Section: T Cells Facilitate Tlr-mediated I/r Organ Damagesupporting
confidence: 61%
“…For example, data show that Tim-3 controls the extent of the inflammatory response by suppressing the TLR4 response (24,25). However, the underlying mechanisms remain largely unclear.…”
mentioning
confidence: 99%
“…However, the underlying mechanisms remain largely unclear. Because sepsis is characterized by immune disorders in which an uncontrolled TLR response plays a major pathogenic role (2,4,26) and because the Tim-3 pathway is actively involved in homeostatic immune regulation and may play a negative regulatory role in the TLR-mediated response (24,25), it is important to know whether the Tim-3 pathway is also involved in the regulation of sepsis, and, if so, whether it plays a negative regulatory role.…”
mentioning
confidence: 99%