T-Cell Monoclonality in the Blood and the Skin Correlates With Poor Response to Treatment in Mycosis Fungoides

Geller, Shamir; Tel-Dan, Shira Fajnerman; Solar, Irit; Sprecher, Eli; Goldberg, Ilan

doi:10.1016/j.clml.2022.10.011

Cited by 3 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, the detection of a monoclonal TCR gene rearrangement by polymerase chain reaction (PCR) in the blood of patients with early-stage MF has been linked to worse overall survival, 6 lower response rates, 7 and a shorter time to systemic treatment (TTST). 8 The impact of dominant blood T-cell clones in early MF becomes more complex if the relationship of the detectable clones in the blood and skin is interrogated.…”

mentioning

confidence: 99%

The overlap of skin and blood T-cell clones in early-stage mycosis fungoides

Joffe,

Bhatti,

Banner

et al. 2023

Blood Advances

View full text Add to dashboard Cite

mentioning

confidence: 99%

The overlap of skin and blood T-cell clones in early-stage mycosis fungoides

Joffe,

Bhatti,

Banner

et al. 2023

Blood Advances

View full text Add to dashboard Cite

Mycosis Fungoides (Cutaneous T-Cell Lymphoma)

Torres,

Ditty,

Razdolsky

2024

Geriatric Dermatology

View full text Add to dashboard Cite

Immunosequencing applications in cutaneous T-cell lymphoma

Mandel,

Gleason,

Joffe

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Immunosequencing has emerged as a newer clinical test for assessment of T-cell clonality in the blood and skin of cutaneous T-cell lymphoma (CTCL) patients. Utilization of immunosequencing, also known as high-throughput sequencing of the T-cell receptor (HTS-TCR), enables identification and quantification of the precise genetic signature of dominant T-cell clones. Although immunosequencing is more sensitive than commonly used methods such as polymerase chain reaction (PCR) paired with capillary electrophoresis or flow cytometry, it remains underutilized for CTCL management. Nonetheless, incorporation of HTS-TCR in clinical practice offers distinct advantages compared to other molecular analyses that may improve diagnostic evaluation, prognostication, and disease monitoring in CTCL. The objective of this comprehensive review is to provide a thorough explanation of the application of immunosequencing in the context of CTCL. We describe the significance of T-cell clonality and the methods used to detect it, including a detailed comparison between PCR paired with capillary electrophoresis and HTS-TCR. The utilization of immunosequencing in the blood and skin of CTCL patients is discussed in depth, specifically outlining how HTS-TCR can assist in diagnosing CTCL, predicting outcomes, and tracking disease progression. Finally, we address the potential applications of immunosequencing in clinical management and research as well as the novel challenges it presents.

show abstract

T-Cell Monoclonality in the Blood and the Skin Correlates With Poor Response to Treatment in Mycosis Fungoides

Cited by 3 publications

References 23 publications

The overlap of skin and blood T-cell clones in early-stage mycosis fungoides

The overlap of skin and blood T-cell clones in early-stage mycosis fungoides

Mycosis Fungoides (Cutaneous T-Cell Lymphoma)

Immunosequencing applications in cutaneous T-cell lymphoma

Contact Info

Product

Resources

About