T-Cell Responses in Children to Internal Influenza Antigens, 1 Year After Immunization With Pandemic H1N1 Influenza Vaccine, and Response to Revaccination With Seasonal Trivalent–inactivated Influenza Vaccine

Lambe, Teresa; Spencer, Alexandra J.; Mullarkey, Caitlin E.; Antrobus, Richard; Yu, Ly-Mee; Whalley, P de; Thompson, Ben; Jones, Claire; Chalk, Jem; Kerridge, Simon; Avs., Hill; Snape, Matthew D.; Pollard, Andrew J.; Gilbert, Sarah C.

doi:10.1097/inf.0b013e318255e443

Cited by 18 publications

(6 citation statements)

References 30 publications

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“…On a clinical level, the study of illness transmission also carries important implications for children's health. Children are especially risky carriers of disease, not only because they are more likely to catch diseases themselves but also by enabling greater transmission of infection to others (Bryant and McDonald, 2009;Lambe et al, 2012;de Lencastre and Tomasz, 2002).…”

Section: Introductionmentioning

confidence: 99%

Using Storybooks to Teach Children About Illness Transmission and Promote Adaptive Health Behavior – A Pilot Study

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Using Storybooks to Teach Children About Illness Transmission and Promote Adaptive Health Behavior – A Pilot Study

et al. 2020

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“…2); neither enrollment age nor sex significantly correlated with SFUs. Previous studies showed that vaccination increases the magnitude of influenza-specific T-cell responses (31,32). We therefore computed the correlation between the efficiency scores and ELISpot responses after adjusting for receipt of the 2008-2009 influenza vaccine.…”

Section: Hlamentioning

confidence: 99%

HLA targeting efficiency correlates with human T-cell response magnitude and with mortality from influenza A infection

Hertz

Oshansky

Roddam

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Experimental and computational evidence suggests that HLAs preferentially bind conserved regions of viral proteins, a concept we term "targeting efficiency," and that this preference may provide improved clearance of infection in several viral systems. To test this hypothesis, T-cell responses to A/H1N1 (2009) were measured from peripheral blood mononuclear cells obtained from a household cohort study performed during the 2009-2010 influenza season. We found that HLA targeting efficiency scores significantly correlated with IFN-γ enzyme-linked immunosorbent spot responses (P = 0.042, multiple regression). A further population-based analysis found that the carriage frequencies of the alleles with the lowest targeting efficiencies, A*24, were associated with pH1N1 mortality (r = 0.37, P = 0.031) and are common in certain indigenous populations in which increased pH1N1 morbidity has been reported. HLA efficiency scores and HLA use are associated with CD8 T-cell magnitude in humans after influenza infection. The computational tools used in this study may be useful predictors of potential morbidity and identify immunologic differences of new variant influenza strains more accurately than evolutionary sequence comparisons. Population-based studies of the relative frequency of these alleles in severe vs. mild influenza cases might advance clinical practices for severe H1N1 infections among genetically susceptible populations.MHC | HLA association | T-cell epitope | Native American

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“…Although subjects receiving monovalent A(H1N1)pdm09 vaccine exhibited T-cell responses to A(H1N1)pdm09, the level was similar to that in unvaccinated individuals (Figure 5). In a similar study, children vaccinated with ASO3-adjuvanted monovalent A(H1N1)pdm09 vaccine demonstrated higher frequencies of IFN-γ–producing cells according to ELISPOT, which persisted into the 2010–2011 season; those vaccinated with unadjuvanted whole-virion vaccine demonstrated a much lower level of IFN-γ–producing cells [33]. Similar to our results, vaccination with 2010–2011 seasonal vaccine further expanded T-cell responses to levels higher than those in subjects who were not previously vaccinated (Figure 5).…”

Section: Discussionmentioning

confidence: 99%

Seasonal Influenza Vaccination of Children Induces Humoral and Cell-Mediated Immunity Beyond the Current Season: Cross-reactivity With Past and Future Strains

et al. 2016

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Background Influenza viruses gradually accumulate point mutations, reducing the effectiveness of prior immune protection. Methods Children aged 9–14 years received 2010–2011 trivalent inactivated influenza vaccine (TIV). Vaccination history, hemagglutination-inhibition (HI) titers, and cell-mediated immune responses were assessed to investigate the cross-reactivity with past and future influenza virus strains. Results 2010–2011 TIV induced significant T-cell responses and HI titers of ≥160, with a fold-rise of ≥4 and titers of ≥100 maintained for >7 months in the majority of children. Pre-existing memory B cells in these children differentiated quickly to antibody-secreting cells to the new vaccine antigens. Children vaccinated in the previous year maintained high HI titers well into 2010, demonstrating elevated HI titers against A/Perth/16/2009, the future (in 2010–2011) H3N2 component. Prior vaccination enhanced CD8+ T-cell responses to A/Perth/16/2009. Children vaccinated with the prior 2009–2010 seasonal vaccine also demonstrated higher preexisting levels of interferon γ–secreting CD4+CD69+ T cells to 2009 pandemic influenza A(H1N1). Children previously vaccinated with 2009–2010 seasonal influenza vaccine also showed greater expansion of tumor necrosis factor α–secreting CD8+CD69+ T cells to 2009 pandemic influenza A(H1N1) upon vaccination in the 2010–2011 season than those who were not previously vaccinated. Conclusions Seasonal influenza viruses continuously drift, which allows them to circumvent protective immunity, but conserved epitopes provide immunological cross-reactivity in children through either vaccination directly or through prime/boost in the prior influenza season.

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T-Cell Responses in Children to Internal Influenza Antigens, 1 Year After Immunization With Pandemic H1N1 Influenza Vaccine, and Response to Revaccination With Seasonal Trivalent–inactivated Influenza Vaccine

Cited by 18 publications

References 30 publications

Using Storybooks to Teach Children About Illness Transmission and Promote Adaptive Health Behavior – A Pilot Study

Using Storybooks to Teach Children About Illness Transmission and Promote Adaptive Health Behavior – A Pilot Study

HLA targeting efficiency correlates with human T-cell response magnitude and with mortality from influenza A infection

Seasonal Influenza Vaccination of Children Induces Humoral and Cell-Mediated Immunity Beyond the Current Season: Cross-reactivity With Past and Future Strains

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