T Cells in Atherosclerosis in Ldlr-/- and Apoe-/- Mice

Getz, Godfrey S.; Reardon, Catherine A.

doi:10.29245/2578-3009/2018/3.1144

Cited by 5 publications

(4 citation statements)

References 63 publications

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“…Besides monocytes-derived macrophages, immune cells, including dendritic cells, mast cells, T cells and B cells, also infiltrate the intima and adventitia of the atherosclerotic plaque [ 66 , 67 ].…”

Section: Pathophysiology Of Atherosclerosismentioning

confidence: 99%

Extracellular Vesicles: Versatile Nanomediators, Potential Biomarkers and Therapeutic Agents in Atherosclerosis and COVID-19-Related Thrombosis

Georgescu

Simionescu

2021

IJMS

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Cells convey information among one another. One instrument employed to transmit data and constituents to specific (target) cells is extracellular vesicles (EVs). They originate from a variety of cells (endothelial, immune cells, platelets, mesenchymal stromal cells, etc.), and consequently, their surface characteristics and cargo vary according to the paternal cell. The cargo could be DNA, mRNA, microRNA, receptors, metabolites, cytoplasmic proteins, or pathological molecules, as a function of which EVs exert different effects upon endocytosis in recipient cells. Recently, EVs have become important participants in a variety of pathologies, including atherogenesis and coronavirus disease 2019 (COVID-19)-associated thrombosis. Herein, we summarize recent advances and some of our own results on the role of EVs in atherosclerotic cardiovascular diseases, and discuss their potential to function as signaling mediators, biomarkers and therapeutic agents. Since COVID-19 patients have a high rate of thrombotic events, a special section of the review is dedicated to the mechanism of thrombosis and the possible therapeutic potential of EVs in COVID-19-related thrombosis. Yet, EV mechanisms and their role in the transfer of information between cells in normal and pathological conditions remain to be explored.

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Section: Pathophysiology Of Atherosclerosismentioning

confidence: 99%

Extracellular Vesicles: Versatile Nanomediators, Potential Biomarkers and Therapeutic Agents in Atherosclerosis and COVID-19-Related Thrombosis

Georgescu

Simionescu

2021

IJMS

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“…66,67 Studies of the APOA1 and APOE knockout mouse models have demonstrated that these apolipoproteins play a fundamental role in CD4+ T-cell homeostasis and function. 68,69 APOA1-deficient mice displayed decreased levels of HDL and higher risk to develop atherosclerosis. 70 This mouse model is also characterized by a higher frequency of T cells in circulation, as systemic lack of APOA1 primes bone marrow stem cells for T-cell generation.…”

Section: Hdls and Their Interactions With Cd4+ T Cellsmentioning

confidence: 99%

Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties

Atehortua,

Davidson,

Chougnet

2024

ATVB

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Several studies in animal models and human cohorts have recently suggested that HDLs (high-density lipoproteins) not only modulate innate immune responses but also adaptative immune responses, particularly CD4+ T cells. CD4+ T cells are central effectors and regulators of the adaptive immune system, and any alterations in their homeostasis contribute to the pathogenesis of cardiovascular diseases, autoimmunity, and inflammatory diseases. In this review, we focus on how HDLs and their components affect CD4+ T-cell homeostasis by modulating cholesterol efflux, immune synapsis, proliferation, differentiation, oxidative stress, and apoptosis. While the effects of apoB-containing lipoproteins on T cells have been relatively well established, this review focuses specifically on new connections between HDL and CD4+ T cells. We present a model where HDL may modulate T cells through both direct and indirect mechanisms.

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“…Within the plaque, T cells exhibit heterogeneity of functions. Some subsets are pro-inflammatory (T helper cells 1), while others tend to suppress inflammation (T helper cells 2) [ 57 ].…”

Section: Pathogenesis Of Atherosclerosismentioning

confidence: 99%

Atherosclerosis Specific Features in Chronic Kidney Disease (CKD)

et al. 2022

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Atherosclerosis is the major cause of cardiovascular disease, leading to a high mortality rate worldwide. Several risk factors are known to favor atherogenesis, among which are high blood pressure, smoking, diabetes mellitus, and others. Chronic kidney disease is another serious health problem associated with significant health care costs, morbidity, and mortality. Chronic kidney disease shares several risk factors with atherosclerosis and cardiovascular diseases, such as hypertension and diabetes mellitus. Additional risk factors for cardiovascular disease development should be considered in patients with chronic kidney disease. Interestingly, patients suffering from chronic kidney disease are more prone to cardiovascular problems than the general population. Moreover, chronic kidney disease is characterized by an increased atherosclerotic burden from the very early stages. The purpose of this review was to summarize data on atherosclerosis in chronic kidney disease, highlighting the specific features of the disease combination.

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T Cells in Atherosclerosis in Ldlr-/- and Apoe-/- Mice

Cited by 5 publications

References 63 publications

Extracellular Vesicles: Versatile Nanomediators, Potential Biomarkers and Therapeutic Agents in Atherosclerosis and COVID-19-Related Thrombosis

Extracellular Vesicles: Versatile Nanomediators, Potential Biomarkers and Therapeutic Agents in Atherosclerosis and COVID-19-Related Thrombosis

Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties

Atherosclerosis Specific Features in Chronic Kidney Disease (CKD)

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