T helper cells promote disease progression of osteoarthritis by inducing macrophage inflammatory protein-1γ

Shen, Po-Chuan; Wu, Chao‐Liang; Jou, I‐Ming; Lee, Chang-Hsing; Juan, H. Y.; Lee, P.-J.; Chen, S.-H.; Hsieh, Jeng-Long

doi:10.1016/j.joca.2011.02.014

Cited by 85 publications

(88 citation statements)

References 28 publications

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“…A possible mechanism is the elevated MMP-9 secretion induced by higher IL-6 expression from monocytes, which is activated by the synovial inflammatory response, thereby disturbing the balance between MMPs and TIMPs and leading to the damage of chondrocytes (Guo et al, 2011). In this process, IL-6 stimulates the production of prostaglandin and collagenase in normal cartilage and synovial cells in order to stimulate the IL-1 induced-MMP response in synovial fibroblasts in rheumatoid arthritis (Litinsky et al, 2006;Wang et al, 2010;Shen et al, 2011) or to elevate the expression of VEGF (vascular endothelial growth factor) type II receptor, thus facilitating MMP-9 secretion (Sakao et al, 2008;Kim et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Correlation between interleukin-6 expression in articular cartilage bone and osteoarthritis

Qu¹,

Wang²,

Tang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. This study aimed to investigate the expressional profile of interleukin-6 (IL-6) in articular cartilage bone of osteoarthritis (OA) patients and its correlation with OA. A total of 30 articular cartilage bone samples from knee OA patients, which were collected by knee arthroscopy or articular surgery, comprised the study group, and 30 samples of normal articular cartilage tissue comprised the control group. Both mRNA (messenger ribonucleic acid) and protein levels of IL-6 and matrix metalloproteinase-9 (MMP-9) were measured and compared, and a correlation analysis was performed between the two. The integral optical density (IOD) values of MMP-9 and IL-6 proteins in the study group were 9.21 ± 3.22 and 8.94 ± 3.17, respectively; these were significantly higher (P < 0.05) than those in the control group at 3.14 ± 1.48 and 6.64 ± 1.53, respectively. The IOD values of mRNA transcripts for MMP-9 and IL-6 in the study group were 8.31 ± 2.28 and 8.78 ± 3.43, respectively; these were significantly higher than the values in the control group at 3.52 ± 1.37 and 5.21 ± 1.72 (P < 0.05), respectively. Further, the correlation analysis revealed significantly positive relationships for both protein (r = 0.434, P = 0.001) and mRNA (r = 14190 X.Q. Qu et al.©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 14189-14195 (2015) 0.413, P = 0.002) levels between MMP-9 and IL-6. In conclusion, articular cartilage tissues in knee OA patients have higher levels of MMP-9 and IL-6 expression, and these may play a synergistic role in OA pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Correlation between interleukin-6 expression in articular cartilage bone and osteoarthritis

Qu¹,

Wang²,

Tang³

et al. 2015

Genet. Mol. Res.

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“…The inflammatory response occurring in the synovial membrane of osteoarthritic patients exhibits features of a T cell immune response [23]. It has been reported that CD3 positive T cells infiltrate in the synovium of osteoarthritic patients [24] and T helper cells promote disease progression of osteoarthritis [25]. Therefore, an antigen-driven immune response exists in osteoarthritic patients.…”

Section: Discussionmentioning

confidence: 99%

Immunogenicity and Immunomodulatory Effects of the Human Chondrocytes, hChonJ

et al. 2016

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Background: Invossa™ (TissueGene-C) is a cell and gene therapy for osteoarthritis. It is composed of primary human chondrocytes (hChonJ cells) and irradiated human chondrocytes modified to express TGF-β1 (hChonJb#7 cells). The hChonJ cells were isolated from a polydactyly donor, and TGF-β1 cDNA was delivered to the cells, generating hChonJb#7 cells. Since the cells are allogeneic, the concern of immune response against cells has been raised. In this study, we investigated the immunogenicity of allogenic human chondrocyte, hChonJ cells.

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“…CD4(+) T cells promote disease progression of OA by inducing macrophage inflammatory protein-1γ. CD4(+) T cells (express the CD4 protein on their surface) are activated during the onset of OA and cause marked damage to cartilage at a later stage (34).…”

Section: Discussionmentioning

confidence: 99%

Obtain osteoarthritis related molecular signature genes through regulation network

Wang

et al. 2011

Mol Med Report

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Abstract. Osteoarthritis (OA), also known as degenerative joint disease or osteoarthrosis, is the most common form of arthritis. OA occurs when cartilage in the joints wears down over time. We used the GSE1919 series to identify potential genes that correlated to OA. The aim of our study was to obtain a molecular signature of OA through the regulation network based on differentially expressed genes. From the result of regulation network construction in OA, a number of transcription factors (TFs) and pathways closely related to OA were linked by our method. Peroxisome proliferator-activated receptor γ also arises as hub nodes in our transcriptome network and certain TFs containing CEBPD, EGR2 and ETS2 were shown to be related to OA by a previous study.

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T helper cells promote disease progression of osteoarthritis by inducing macrophage inflammatory protein-1γ

Abstract: CD4(+) T cells were activated during the onset of OA, but cartilage damage was more prominent at a later stage. CD4(+) T cells were involved in the pathogenesis of OA: they induced MIP-1γ expression and subsequent osteoclast formation.

Cited by 85 publications

References 28 publications

Correlation between interleukin-6 expression in articular cartilage bone and osteoarthritis

Correlation between interleukin-6 expression in articular cartilage bone and osteoarthritis

Immunogenicity and Immunomodulatory Effects of the Human Chondrocytes, hChonJ

Obtain osteoarthritis related molecular signature genes through regulation network

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