T-lymphocyte subpopulations in B-cell-derived non-hodgkin's lymphomas and hodgkin's disease

Knowles, Daniel M.; Halper, James P.; Jakobiec, Frederick A.

doi:10.1002/1097-0142(1984)54:4<644::aid-cncr2820540410>3.0.co;2-a

Cited by 37 publications

(13 citation statements)

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“…The number of reactive cells varies widely in lymphoid neoplasms. Hodgkin's lymphoma contains a larger percentage of T-cells when compared to B-cell lymphomas (Knowles, Halper & Jakobiec 1984). Deposits of peripheral T-cell lymphomas often contain a significant number of reactive histiocytes (Kadin et al 1983).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemistry of primary gastrointestinal lymphomas: a study of 76 cases

1986

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A retrospective study of 76 primary gastrointestinal lymphomas utilizing an avidin: biotinylated horseradish peroxidase complex (ABC) technique demonstrated 22 B-cell lymphomas, including two associated with alpha-heavy chain disease. Seven cases were classified as true histiocytic lymphomas based on a positive reaction for one or more of three histiocytic enzyme markers utilized, predominantly alpha-1-antitrypsin and alpha-1-antichymotrypsin. However, in 20 cases, an intense admixture of reactive histiocytes was noted and these cells stained preferentially for the enzyme, lysozyme. Twenty cases, which stained for both kappa and lambda light chains and positively or negatively for albumin, could not be classified and 27 cases failed to stain with any of the antisera utilized.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemistry of primary gastrointestinal lymphomas: a study of 76 cases

1986

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“…by guest www.bloodjournal.org From 6:1. [149][150][151][152] Moreover, the majority of CD4 ϩ T cells in the infiltrate show features of Th2 cells. 153 The increase in CD4 ϩ T-cell numbers in cHL tumors is associated with a decrease in CD4 ϩ T cells in the peripheral blood, consistent with a displacement of these cells from the circulation into the involved tissues.…”

Section: Cytokines and The Reactive Infiltratementioning

confidence: 99%

The role of cytokines in classical Hodgkin lymphoma

Skinnider

Mak

2002

Blood

462

370

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IntroductionClassical Hodgkin lymphoma (cHL) is a lymphoid malignancy with characteristic features that distinguish it from nodular lymphocyte-predominant HL (NLPHL) and non-Hodgkin lymphomas (NHLs). 1,2 The malignant cells in cHL, termed the Reed-Sternberg (RS) cells, constitute only a minor component of the tumor, whereas the majority of the malignancy is composed of a mixed inflammatory infiltrate variably composed of lymphocytes, eosinophils, fibroblasts, macrophages, and plasma cells. Patients with cHL also commonly present with constitutional symptoms such as fever, weight loss, and night sweats, and an apparent systemic defect in cell-mediated immune responses. Many of these distinctive clinical and histopathologic features of cHL reflect an abnormal immune response thought to be due largely to the effects of a wide variety of cytokines and chemokines that are primarily produced by the RS cells, but also secondarily by the surrounding reactive infiltrate. This review summarizes the data on cytokine production in cHL, examines cytokine signaling, and discusses the role of cytokines in the clinical and pathologic features of this disease.Classical HL is now considered a distinct clinicopathologic entity from NLPHL and can be divided into 4 morphologic subtypes: nodular sclerosis cHL (NSHL), mixed cellularity cHL (MCHL), lymphocyte-rich cHL (LRCHL), and lymphocytedepleted cHL (LDHL). 2 There are few data on cytokine involvement in LRCHL and LDHL, because each disease comprises less than 5% of all cHL cases. As a result, nearly all of the data on the role of cytokines in cHL are derived from the study of NSHL and MCHL cases.Cytokines are low-molecular-weight proteins with a wide variety of functions. They not only regulate immune and inflammatory responses but also contribute to hematopoiesis, wound healing, and other biologic processes. Cytokines are extremely potent molecules active in nanomolar to picomolar concentrations. Typically, a cytokine either acts in a paracrine manner to modulate the activity of surrounding cells, or in an autocrine fashion to affect the cell that produced it. In the context of cHL, cytokines produced by RS cells are thought to contribute to the pathogenesis of this disease both by acting as autocrine growth factors and by initiating and sustaining the reactive infiltrate. Alternatively, cytokines produced by surrounding reactive cells may be contributing to RS cell proliferation and survival.The expression and activity of cytokines in cHL can be studied using cell lines derived from RS cells and in primary cHL tissues. Each approach has its limitations, so that a combination of both strategies provides the most comprehensive information on the activity of a specific cytokine. Cell lines derived from RS cells have been extremely useful in the study of cHL. 3,4 However, outgrowth of such a cell line from cHL patient tissues is extremely rare, so that the few cell lines available may not represent the full spectrum of clinical and pathologic features of this disease. The RS cell li...

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“…They tend to be predominantly CD4+, and frequently express antigens associated with chronic activation such as class II MHC [5,11,15]. The idea that TIL's may interact with the tumour cells [10] and may have anti-tumour activity [13] has been explored over the years.…”

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confidence: 99%