T lymphocytes and aortic aneurysms

Lv, Bingjie; Li, JingYong; Cheng, Xiang

doi:10.1007/s11427-014-4699-x

Cited by 9 publications

(9 citation statements)

References 70 publications

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“…The role of T-cells in aneurysms is largely unclear ( 23 ). A recent study of human abdominal aortic aneurysms unveiled an association of tissue-infiltrating T-cells with disease severity ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Deep Phenotyping of T-Cells Derived From the Aneurysm Wall in a Pediatric Case of Subarachnoid Hemorrhage

et al. 2022

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Intracranial aneurysms (IAs) are very rare in children, and the characteristics of the T-cells in the IA wall are largely unknown. A comatose 7-years-old child was admitted to our center because of a subarachnoid hemorrhage due to a ruptured giant aneurysm of the right middle cerebral artery. Two days after the aneurysm clipping the patient was fully awake with left hemiparesis. T-cells from the IA wall and from peripheral blood of this patient were analyzed by multi-dimensional flow cytometry. Unbiased analysis, based on the use of FlowSOM clustering and dimensionality reduction technique UMAP, indicated that there was virtually no overlap between circulating and tissue-infiltrating T-cells. Thus, naïve T-cells and canonical memory T-cells were largely restricted to peripheral blood, while CD4-CD8-T-cells were strongly enriched in the IA wall. The unique CD4+, CD8+ and CD4-CD8-T-cell clusters from the IA wall expressed high levels of CCR5, Granzyme B and CD69, displaying thus characteristics of cytotoxic and tissue-resident effector cells. Low Ki67 expression indicated that they were nevertheless in a resting state. Among regulatory T-cell subsets, Eomes+Tr1-like cells were strongly enriched in the IA wall. Finally, analysis of cytokine producing capacities unveiled that the IA wall contained poly-functional T-cells, which expressed predominantly IFN-γ, TNF and IL-2. CD4+T-cells co-expressed also CD40L, and produced some IL-17, GM-CSF and IL-10. This report provides to our knowledge the first detailed characterization of the human T-cell compartment in the IA wall.

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Section: Discussionmentioning

confidence: 99%

Deep Phenotyping of T-Cells Derived From the Aneurysm Wall in a Pediatric Case of Subarachnoid Hemorrhage

et al. 2022

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“…32 Lymphocytes play a role in AAA pathogenesis through secretion of cytokines, modulation of inflammatory process, and extracellular matrix remodeling. 33,34 The modulation of their count and activation might thus be involved in pathophysiological features leading to AAA formation and impact on the postoperative outcome in patients undergoing surgical repair. All in all, PLR represents a marker of systemic inflammation and extreme values are predictive of postoperative events in patients undergoing AAA surgical repair.…”

Section: Discussionmentioning

confidence: 99%

Association of Platelet to Lymphocyte Ratio and Risk of 30-Day Postoperative Complications in Patients Undergoing Abdominal Aortic Surgical Repair

Lareyre

Carboni²,

Chikande³

et al. 2018

Vasc Endovascular Surg

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“…We demonstrated that the aortic walls of TAA patients display significantly more T cells than those in normal aortas. However, it should be noted that different T cell subsets have complex effects during the inflammatory response and might even contradict each other ( 44 ). For example, Th1 and Th2 (subsets of naïve CD4-positive T cells) are characterized by the production of IFN-γ and IL-4, respectively ( 45 ).…”

Section: Discussionmentioning

confidence: 99%

Integrating Bulk Transcriptome and Single-Cell RNA Sequencing Data Reveals the Landscape of the Immune Microenvironment in Thoracic Aortic Aneurysms

Guo

Huo

Xiao

et al. 2022

Front. Cardiovasc. Med.

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Thoracic aortic aneurysm (TAA) is a life-threatening cardiovascular disease whose formation is reported to be associated with massive vascular inflammatory responses. To elucidate the roles of immune cell infiltration in the pathogenesis underlying TAA, we utilized multiple TAA datasets (microarray data and scRNA-seq data) and various immune-related algorithms (ssGSEA, CIBERSORT, and Seurat) to reveal the landscapes of the immune microenvironment in TAA. The results exhibited a significant increase in the infiltration of macrophages and T cells, which were mainly responsible for TAA formation among the immune cells. To further reveal the roles of immunocytes in TAA, we inferred the intercellular communications among the identified cells of aortic tissues. Notably, we found that in both normal aortic tissue and TAA tissue, the cells that interact most frequently are macrophages, endothelial cells (ECs), fibroblasts, and vascular smooth muscle cells (VSMCs). Among the cells, macrophages were the most prominent signal senders and receivers in TAA and normal aortic tissue. These findings suggest that macrophages play an important role in both the physiological and pathological conditions of the aorta. The present study provides a comprehensive evaluation of the immune cell composition and reveals the intercellular communication among aortic cells in human TAA tissues. These findings improve our understanding of TAA formation and progression and facilitate the development of effective medications to treat these conditions.

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T lymphocytes and aortic aneurysms

Cited by 9 publications

References 70 publications

Deep Phenotyping of T-Cells Derived From the Aneurysm Wall in a Pediatric Case of Subarachnoid Hemorrhage

Deep Phenotyping of T-Cells Derived From the Aneurysm Wall in a Pediatric Case of Subarachnoid Hemorrhage

Association of Platelet to Lymphocyte Ratio and Risk of 30-Day Postoperative Complications in Patients Undergoing Abdominal Aortic Surgical Repair

Integrating Bulk Transcriptome and Single-Cell RNA Sequencing Data Reveals the Landscape of the Immune Microenvironment in Thoracic Aortic Aneurysms

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