1981
DOI: 10.1084/jem.154.2.491
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T lymphocytes specific for immunoglobulin allotype. II. Cloned Igh-1(b)- specific cytotoxic T cells

Abstract: Despite much effort, the structural features of the surface molecules responsible for antigen recognition by thymus-derived (T) cells remain unclear (l, 2) . Progress in this area will in part depend on the availability of homogeneous T cells from which to isolate and purify T cell receptor molecules in quantities sufficient to characterize them. With the advent of recent technology, the development ofT cell clones (3), and the description of mitogen-induced T cell growth factors (TCGF; 4, 5), t it has become … Show more

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Cited by 21 publications
(4 citation statements)
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“…An intriguing series of findings emerging from the diverse studies on isotype restriction is that pertaining to the regulation of IgG2a expression. Neonatal exposure to anti-IgM antibodies results in chronic suppression of the Ig-Ib allotype (expressed on >' 2a molecules) but not IgGl (Black & Herzenberg 1979) and suppression of Ig-lb-producing myeloma cells by Ig-lb-speciftc cytotoxic cell lines has been demonstrated (Snodgrass et al 1981). In the experiments of Seman & Siiberfarb (1979) IgG2a-and antigen-specific suppressor T cells, probably acting by elimination of lgG2a-speciric Tig, have also been shown to result in the selective low IgG2a responsiveness of BIO mice to SRBC.…”
Section: Evidence For Helper Cell Heterogeneity In Other Systemsmentioning
confidence: 99%
“…An intriguing series of findings emerging from the diverse studies on isotype restriction is that pertaining to the regulation of IgG2a expression. Neonatal exposure to anti-IgM antibodies results in chronic suppression of the Ig-Ib allotype (expressed on >' 2a molecules) but not IgGl (Black & Herzenberg 1979) and suppression of Ig-lb-producing myeloma cells by Ig-lb-speciftc cytotoxic cell lines has been demonstrated (Snodgrass et al 1981). In the experiments of Seman & Siiberfarb (1979) IgG2a-and antigen-specific suppressor T cells, probably acting by elimination of lgG2a-speciric Tig, have also been shown to result in the selective low IgG2a responsiveness of BIO mice to SRBC.…”
Section: Evidence For Helper Cell Heterogeneity In Other Systemsmentioning
confidence: 99%
“…Both can be induced by priming with purified Igh-l b proteins and both show specificity for Igh-l b proteins, one by rosetting and the other by cytotoxicity . Moreover, as described in the accompanying paper, a cytotoxic Igh-lb-specific T cell line is able to suppress expression of Igh-l b in vivo (32). We therefore feel that the possibility remains that allotype-specific Tc could have a physiologic role in the regulation of allotype suppression .…”
Section: Discussionmentioning
confidence: 84%
“…The strongest evidence supporting the conclusion that these Tc are specific for allotypic determinants of the Igh-l b molecule is presented in the accompanying paper (32) . Tc cells cloned from bulk populations similar to those described in Fig.…”
Section: Discussionmentioning
confidence: 93%
“…Although one interpretation of these results is that the structural gene for the T cell receptor is linked to Igh, in view of the capacity for CTL recognition of allotype (18), an alternative explanation for the observed Igh-linked repertoire differences could be either a positive or negative environmental selection mechanism that reflects such recognition. Future experiments will attempt to determine whether the influence of Igh-linked genes is intracellular or environmental in origin.…”
Section: Discussionmentioning
confidence: 99%