T₃Thyrotoxicosis Due to Metastatic Thyroid Carcinoma

Triiodothyronine-Producing Metastatic Follicular Thyroid Carcinoma

“…In contrast to the patient of Sung et al (1), the much smaller extent of functioning metastases in the patient reported herein was sufficient to sustain normal plasma T3 levels. It follows that serum T3 concentration in this set of circumstances might be a function of the mass of neoplastic tissue.…”

“…Predominant triiodothyronine (T3) production resulting in T3 toxicosis has been described in a patient with metastatic follicular carcinoma of the thyroid (1). A similar predominance of T3 secretion without hyperthyroidism was noted in a totally thyroidectomized patient with metastatic follicular carcinoma of the thyroid which constitutes the subject of this report.…”

“…Predominent T3 secretion from metastatic thyroidal carcinoma however, was noted in only one patient previously (1). Whether this constitutes a functional hallmark of follicular thyroidal carcinoma or is an effect of the inorganic iodide cannot be decided on the basis of the data available in our patient.…”

Un cas d'hyperthyroïdie par métastases sécrétantes de cancer thyroïdien différencié. Revue de la littérature

“…Les caractéristiques cliniques et évolutives des cancers avec métastases sécrétantes peuvent être dégagées des 47 cas cliniques certains d'hyperthyroïdie par métastases sécrétantes de cancer thyroïdien, recensés dans la littérature médicale entre 1946 et 2005 [1, [4][5][6][7][8][10][11][12][14][15][16][17][18][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][38][39][40][41][43][44][45][46][47]. Nous n'avons retenu que les observations dans lesquelles l'hyperthyroïdie pouvait être attribuée de façon formelle aux métastases, soit parce que les patients avaient bénéficié d'une thyroïdecto-mie totale auparavant, soit parce que la captation cervicale de l'iode était inférieure à 5 %.…”

Hyperthyroidism Induced by Secondary Carcinoma in the Thyroid

“…Careful enquiry eliminated the possibility of thyroid hormone or iodide ingestion. Occasionally a primary thyroid carcinoma produces excessive thyroid hormone secretion (Pochin, 1969;Valenta et al, 1970;Sung & Cavalieri, 1973) but, to our knowledge, this has always been associated with high uptake of "' I into tumour tissue. The possibility of a coincidental thyroiditis producing transient hyperthyroidism in which "'I uptake may be diminished or suppressed (VolpC, 1971 ;Dorfman et al, 1977) was unlikely in view of the negative thyroid antibodies.…”