T-Zonen-Lymphom ? Klinisches Bild, Therapie und Prognose

Helbron, Dagmar; Brittinger, G; Lennert, K.

doi:10.1007/bf01008087

Cited by 35 publications

(20 citation statements)

References 5 publications

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“…In our series, lym phocyte activity was not studied but the secondary occurrence of an authentic IgA/kappa plasmocytoma in case 3 and the late appearance of a monoclonal plasmatic immunoglobulin in case 1 are suggestive either of a helper effect of tumor T cells or of an association of independent T and B cell malignant proliferations. Hypergamma globulinemia which was recorded in our series at high levels in case 1 and at more moderate levels in cases 2 and 3 has pre viously been described with non-MF/SS peripheral Tcell lymphomas [12,29,[35][36][37]. This finding also suggests helper activity [38].…”

Section: Discussionsupporting

confidence: 65%

Non Lymphoblastic T Cell Lymphomas with Prevalent Skin Involvement Different from Mycosis Fungoides or Sézary’s Syndrome

Grob

Horchowski²,

Tubiana³

et al. 1988

Dermatology

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A retrospective study of 23 cases of nonlymphoblastic T cell lymphomas with no features of either mycosis fungoides (MF) or Sézary syndrome (SS) was carried out. 6 patients exhibited cutaneous (or mucous) lesions and are presented herein. There was no detectable visceral or node involvement except in 1 patient. 3 cases were immunologically proven to be of peripheral T cell origin. Except T cell lymphomas in Japan and in the Caribbean area, the frequency of prevalent skin involvement is reportedly very low in non-MF/SS non lymphoblastic T cell lymphomas. However, it is likely that this frequency has been underestimated in Western countries. The histologic features of our cases run the heterogeneous spectrum of recently described node-based forms of peripheral T cell lymphomas: ‘angioimmunoblastic lymphadenopathy with dysproteinemia’ -like lymphoma, large T cell lymphoma, multilobulated cell lymphoma, T zone lymphoma. The histologic pattern of skin infiltration was different from that of MF/SS. One case was initially suggestive of a pseudolymphoma and had a prolonged evolution but the other patients suffered from rapid extracutaneous involvement and fatal evolution with resistance to treatment. Cutaneous plasmocytomas were seen in 1 case. Hence, certain cutaneous T cell lymphomas exhibit histologic, immunological and developmental features similar to those of node-based peripheral T cell lymphomas but different from those of MF/SS.

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Section: Discussionsupporting

confidence: 65%

Non Lymphoblastic T Cell Lymphomas with Prevalent Skin Involvement Different from Mycosis Fungoides or Sézary’s Syndrome

Grob

Horchowski²,

Tubiana³

et al. 1988

Dermatology

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“…In the dog, peripheral blood lymphocytosis is described in 48%–64% of cases and neoplastic cells can be detected in the peripheral blood in 100% of cases in which peripheral blood was available for flow cytometric analysis, including many cases in which the absolute lymphocyte count was normal [16,66,69]. Bone marrow involvement in both hTZL and cTZL appears uncommon and peripheral blood cytopenias are very uncommon [69,71]. Limited hTZL-specific immunophenotypic information is available, but the tumor cells are described as CD2+, CD3+, CD5+, and CD4+ [72].…”

Section: T-cell Neoplasmsmentioning

confidence: 99%

The Comparative Diagnostic Features of Canine and Human Lymphoma

Seelig

Avery

Ehrhart

et al. 2016

Veterinary Sciences

102

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The non-Hodgkin lymphomas (NHLs) are a heterogeneous family of lymphoid malignancies that are among the most common neoplasms of both dogs and humans. Owing to shared molecular, signaling, incidence, and pathologic features, there is a strong framework supporting the utilization of canine lymphoma as a comparative, large animal model of human NHL. In alignment with the biologic similarities, the current approach towards the diagnosis and classification of canine lymphoma is based upon the human World Health Organization guidelines. While this approach has contributed to an increasing appreciation of the potential biological scope of canine lymphoma, it has also become apparent that the most appropriate diagnostic philosophy must be multimodal, namely by requiring knowledge of microscopic, immunophenotypic, and clinical features before establishing a final disease diagnosis. This review seeks to illustrate the comparative similarities and differences in the diagnosis of canine lymphoma through the presentation of the microscopic and immunophenotypic features of its most common forms.

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“…Lung or pleura are often affected (45%). 92 The serum immunoglobulin concentration often shows mild to moderate polyclonal increase. Leukaemia is rare.…”

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confidence: 99%