T102C polymorphism of the 5‐HT2A receptor gene may be associated with temporomandibular dysfunction

Mutlu, Necip; Erdal, Mehmet Emin; Herken, Hasan; Öz, Gülsün; BAYAZİT, Yıldırım Hakan

doi:10.1111/j.1601-0825.2004.01037.x

Cited by 34 publications

(30 citation statements)

References 16 publications

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“…Overrepresentation of the C/C variant of the 5-HT2A receptor gene was found in temporomandibular dysfunction suggesting a possible role of the serotonergic system in this disease as well [33]. Juhasz and colleagues have suggested that genetic susceptibility to migraine may be associated with a locus at or near the 5-HT transporter gene [34].…”

Section: Irritable Bowel Syndrome Geneticsmentioning

confidence: 97%

“…The C/C genotype over represented in patients; T/T genotype over represented in controls [33] Migraine future science group future science group the 5-HT transporter (5-HTT) regulates the duration and strength of interactions between 5-HT and its receptors. A polymorphism within the 5-HTT 5´ upstream region (5-HTTLPR) has been reported, of which the majority is composed of either 14 (S) or 16 (L) repetitive elements.…”

Section: Fms Patientsmentioning

confidence: 99%

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The Genetics of Fibromyalgia Syndrome

2006

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Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. Although the etiology of FMS is not completely understood, varieties of neuroendocrine disturbances, as well as abnormalities of autonomic function, have been implicated in its pathogenesis. The exposure of a genetically predisposed individual to a host of environmental stressors is presumed to lead to the development of FMS. Fibromyalgia overlaps with several related syndromes, collectively compromising the spectrum of the functional somatic disorder. FMS is characterized by a strong familial aggregation. Recent evidence suggests a role for polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems in the etiopathogenesis of FMS. These polymorphisms are not specific for FMS and are similarly associated with additional comorbid conditions. The mode of inheritance in FMS is unknown, but it is most probably polygenic. Recognition of these gene polymorphisms may help to better subgroup FMS patients and to guide a more rational pharmacological approach. Future genetic studies conducted in larger cohorts of FMS patients and matched control groups may further illuminate the role of genetics in FMS.

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Section: Irritable Bowel Syndrome Geneticsmentioning

confidence: 97%

Section: Fms Patientsmentioning

confidence: 99%

The Genetics of Fibromyalgia Syndrome

2006

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“…Studies of the HTR2A have also consistently shown that the silent 102T > C polymorphism is associated with an increased risk of both FMS [9,22] and TMJD [23].…”

Section: Serotoninergic Candidate Genesmentioning

confidence: 98%

Update on the genetics of the fibromyalgia syndrome

Ablin

Buskila

2015

Best Practice & Research Clinical Rheumatology

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“…For a long time it has been known that 5-HT2 A receptors activate the phospholipase C-β second messenger pathway,1 and 5-HT2 A receptors triggered a rapid and transient tyrosine phosphorylation of Jak2 kinase in response to serotonin 3. In addition, previous studies have shown an association between the rs6313 (T102C polymorphism) of HTR2A and diseases with musculoskeletal manifestations, ie, fibromyalgia4 and temporomandibular dysfunction 5. Furthermore, a recent study showed that patients with rheumatoid arthritis (RA) had a decreased B max of 5-HT2 A receptors compared with age- and sex-matched controls 6.…”

mentioning

confidence: 99%