T2* cardiovascular magnetic resonance in the management of thalassemia patients in Oman

MRI assessment of excess cardiac iron in thalassemia major: When to initiate?

“…In this study, we have demonstrated that detectable cardiac iron overload can occur at an even younger age than reported by previous studies. [15][16][17]28 However, no patient under 5 years of age had an abnormal cardiac T2* from our data. Therefore it may be necessary to start monitoring cardiac iron overload with MRI at 5 years of age, at least for the patients in our region.…”

“…The primary goal of this study was to determine at what age cardiac T2* screening should be initiated for patients with TM. In this study, we have demonstrated that detectable cardiac iron overload can occur at an even younger age than reported by previous studies . However, no patient under 5 years of age had an abnormal cardiac T2* from our data.…”

Evaluation of cardiac iron load by cardiac magnetic resonance in thalassemia

“…It is recommended that MRI T2* should be repeated every 2 years if T2* >20ms, every year if between 20-10 ms, every 6 months if <10 ms and even earlier if evidence of cardiac dysfunction is documented. In a population who have not received any form of iron chelation, this evaluation may be necessary even in younger patients [20,21].…”

Cardiac iron measurement and iron chelation therapy in patients with β thalassaemia major: experience from Taiwan

“…The results from studies investigating the relationship between cardiac T2* values and different parameters of body iron load in various populations have been inconsistent (Anderson et al ., ; Kolnagou et al ., ; Noetzli et al ., ; Tanner et al ., ; Daar et al ., ), maybe indicating that the relationship between cardiac iron load and cardiac function, or between cardiac iron load and biochemical parameters, such as serum ferritin levels, could be population‐specific. This premise is supported by evidence that suggest a genetic component in the susceptibility of cardiac iron loading (Wu et al ., ).…”