T2 Mapping of Rat Patellar Cartilage

Watrin, A.; Ruaud, Jean-Pierre; Olivier, Pierre; Guingamp, Natacha C.; Gonord, P.; Netter, Patrick; Blum, Alain; Guillot, Geneviève; Gillet, Pierre; Lœuille, Damien

doi:10.1148/radiology.219.2.r01ma32395

Cited by 68 publications

(56 citation statements)

References 32 publications

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“…However, the T2 value was still significantly higher than the control group, and pathologic examination also showed that the muscular lesions had not returned to normal on d 14 after injury, indicating that the T2 map quantitative diagnosis was more sensitive than T2WI. T2 mapping technique, especially in experimental high e362 magnetic field conditions (>3T), has been widely used in orthopedics to distinguish cartilage lesions from repair and evaluate outcomes of bone graft [9][10][11]. Although more than 3.0T magnetic field can be quantitatively more accurate, clinical application of low magnetic field such as 1.5 T was more general.…”

Section: Discussionmentioning

confidence: 99%

MRI Quantitative Study and Pathologic Analysis of Crush Injury in Rabbit Hind Limb Muscles

Zhang

Ding

Wang

et al. 2011

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

MRI Quantitative Study and Pathologic Analysis of Crush Injury in Rabbit Hind Limb Muscles

Zhang

Ding

Wang

et al. 2011

Journal of Surgical Research

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“…We have developed a rat model of patellar cartilage defect, an anatomical structure for which T2 mapping, biochemical and histological data have previously been validated [7][8][9]. In the present study, we have explored the accuracy of T2 mapping at 8.5 T in characterizing cartilage repair tissue, a "tissue engineering" approach, after a chondral lesion in rat patella and the implantation of a biomaterial seeded or not with autologous chondrocytes.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cartilage repair tissue after biomaterial implantation in rat patella by using T2 mapping

Pinzano

Ruaud

Chéli

et al. 2004

MAGMA

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To evaluate the ability of MR T2 mapping (8.5 T) to characterize ex vivo longitudinally, morphologically and quantitatively, alginate-based tissue engineering in a rat model of patellar cartilage chondral focal defect. Calibrated rat patellar cartilage defects (1.3 mm) were created at day 0 (D0) and alginate sponge with (Sp/C+) or without (Sp/C-) autologous chondrocytes were implanted. Animals were sacrificed sequentially at D20, D40 and D60 after surgery and dissected patellae underwent MRI exploration (8.5 T). T2 values were calculated from eight SE images by using nonlinear least-squares curve fitting on a pixel-by-pixel basis (constant repetition time of 1.5 s, eight different echo times: 5.5, 7.5, 10.5, 12.5, 15.0, 20.0, 25.0 and 30.0 ms). On the T2 map, acquired in a transversal plane through the repair zone, global T2 values and zonal variation of T2 values of repair tissue were evaluated versus control group and compared with macroscopic score and histological studies (toluidine blue, sirius red and hematoxylin-eosin). "Partial", "total" and "hypertrophic" repair patterns were identified. At D40 and D60, Sp/C+ group was characterized by a higher proportion of "total" repair in comparison to Sp/C- group. At D60, the proportion of "hypertrophic" repair was two fold in Sp/C- group versus Sp/C+ group. As confirmed morphologically and histologically, the T2 map also permitted the distinction of three types of repair tissue: "total", "partial" and "hypertrophic". "Total" repair tissue was characterized by high T2 values versus normal cartilage (p<0.05). Zonal variation, reflecting the collagen network organization, appeared only at D60 for Sp/C+ group (p<0.05). "Hypertrophic" tissue, mainly observed at D60, presented high T2 global values without zonal variation with cartilage depth. These results confirm the potency of the MR T2 map (8.5 T) to characterize macroscopically and microscopically the patterns of the scaffold guided-tissue repair of a focal chondral lesion in the rat patella ("total", "partial" and "hypertrophic"). On T2 map, three parameters (i.e. MRI macroscopic pattern, T2 global values and zonal variation of T2 values) permit to characterize chondral repair tissue, as a virtual biopsy.

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“…It is sensitive to tissue anisotropy, and provides compositional information on the cartilage collagen network, water content and proteoglycans concentration (6). T2 mapping has been studied in both animal (7,8) and human knee cartilage models, especially in the femoropatellar Once a T2 prolongation was detected, a comparison with the con ventional MRI images (sagittal T1 weighted images and PDW with saturation of fat signal images) was performed by the 2 radiologists to retrospectively determine if T2 pro longations were linked to initially overlooked lesions in conventional MRI sequences.…”

mentioning

confidence: 99%

Correlation of MRI T2 mapping sequence with knee pain location in young patients with normal standard MRI

Dautry

Bousson

Manelfe

et al. 2014

Journal of the Belgian Society of Radiology

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T2 Mapping of Rat Patellar Cartilage

Abstract: T2 mapping allows characterization of variations in cartilage matrix constituents and thickness.

Cited by 68 publications

References 32 publications

MRI Quantitative Study and Pathologic Analysis of Crush Injury in Rabbit Hind Limb Muscles

MRI Quantitative Study and Pathologic Analysis of Crush Injury in Rabbit Hind Limb Muscles

Evaluation of cartilage repair tissue after biomaterial implantation in rat patella by using T2 mapping

Correlation of MRI T2 mapping sequence with knee pain location in young patients with normal standard MRI

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