T2* Mapping to characterize intestinal fibrosis in crohn's disease

Abstract

1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.

Cardiovascular magnetic resonance T2* mapping for structural alterations in hypertrophic cardiomyopathy

“…As the study was conducted retrospectively, we were not able to quantify perfusion by CMR or verify the relation between T2* and fibrosis in histopathologic analyses. However, studies from different tissues have already shown a correlation between T2* values and collagen or LGE [14,[16], [17], [18]]. In addition, microvascular dysfunction in HCM has already been described in literature and perfusion studies in CMR have shown good accuracy for the description of microvascular dysfunction [8,12].…”

“…However, in terms of further structural characterization and because not all HCM patients are able to receive contrast agents due to contraindications such as renal failure, T2* magnetic relaxation parameters (parametric mapping) have been exploited to visualize mesoscopic (structure of the tissue) magnetic field inhomogeneities [[13], [14], [15]]. For instance, T2* was demonstrated to characterize fibrosis in extracardiac tissues such as the intestinal tract, but also in ischemic and fibrotic segments after myocardial infarction [[15], [16], [17], [18]]. In addition, histopathologic substrates of T2* and a correlation of T2* to flow analyses have already been studied in affected tissues [16,17,19,20].…”

“…For instance, T2* was demonstrated to characterize fibrosis in extracardiac tissues such as the intestinal tract, but also in ischemic and fibrotic segments after myocardial infarction [[15], [16], [17], [18]]. In addition, histopathologic substrates of T2* and a correlation of T2* to flow analyses have already been studied in affected tissues [16,17,19,20]. The diagnostic value of T2* mapping during the course of HCM has not been investigated yet, but according to recent literature and structural alterations including relative ischemia and fibrosis, decreased T2* vales can be suggested [8,12].…”

Cardiovascular magnetic resonance T2* mapping for the assessment of cardiovascular events in hypertrophic cardiomyopathy

“…In this context, reduced T2* values have already shown the potential to describe structural alterations suggestive of ischaemic alterations, collagen areas or haemorrhage in cardiac and extracardiac tissues 15 18 21. According to this, histopathological substrates of T2* and a correlation of T2* to flow analyses have been studied 16 17 19 20 30. Recently, reduced T2* values have been described in a group of patients with HCM potentially triggered through relative ischaemia 22.…”

“…CMR is able to detect myocardial alterations and relative ischaemia using contrast agent and parametric mapping 6 13–15. In particular, T2* mapping has proven feasibility to detect ischaemic segments in extracardiac organs but also in myocardial infarction and coronary artery disease (CAD) 15–21. Reduced T2* values have been described in patients with HCM potentially triggered through relative ischaemia 22.…”