T2 Relaxation Times Correlated with Stage of Lumbar Intervertebral Disk Degeneration and Patient Age

Marinelli, Nicholas L.; Haughton, Victor M.; Anderson, Paul A.

doi:10.3174/ajnr.a2080

Cited by 94 publications

(121 citation statements)

References 21 publications

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“…5: R = 0.97, P \ 0.01). As it has previously been shown that T2 correlate with IVD degeneration [14,16,17], these findings further emphasize the correlation between Dl and IVD degeneration. 117 ±13 89 ±18 52 ±10 38 ±6 P = 0.000* P= 0.000* P = 0.000* P= 0.000* P = 0.004* P= 0.011* P = 0.000* P= 0.001* P = 0.000* P= 0.000* P = 0.000* P= 0.000*…”

Section: Correlation Between Different Histogram Featuressupporting

confidence: 84%

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MRI histogram analysis enables objective and continuous classification of intervertebral disc degeneration

et al. 2017

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Purpose Magnetic resonance imaging (MRI) is the best diagnostic imaging method for low back pain. However, the technique is currently not utilized in its full capacity, often failing to depict painful intervertebral discs (IVDs), potentially due to the rough degeneration classification system used clinically today. MR image histograms, which reflect the IVD heterogeneity, may offer sensitive imaging biomarkers for IVD degeneration classification. This study investigates the feasibility of using histogram analysis as means of objective and continuous grading of IVD degeneration. Methods Forty-nine IVDs in ten low back pain patients (six males, 25-69 years) were examined with MRI (T2-weighted images and T2-maps). Each IVD was semi-automatically segmented on three mid-sagittal slices. Histogram features of the IVD were extracted from the defined regions of interest and correlated to Pfirrmann grade. Results Both T2-weighted images and T2-maps displayed similar histogram features. Histograms of well-hydrated IVDs displayed two separate peaks, representing annulus fibrosus and nucleus pulposus. Degenerated IVDs displayed decreased peak separation, where the separation was shown to correlate strongly with Pfirrmann grade (P \ 0.05). In addition, some degenerated IVDs within the same Pfirrmann grade displayed diametrically different histogram appearances. Conclusions Histogram features correlated well with IVD degeneration, suggesting that IVD histogram analysis is a suitable tool for objective and continuous IVD degeneration classification. As histogram analysis revealed IVD heterogeneity, it may be a clinical tool for characterization of regional IVD degeneration effects. To elucidate the usefulness of histogram analysis in patient management, IVD histogram features between asymptomatic and symptomatic individuals needs to be compared.

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Section: Correlation Between Different Histogram Featuressupporting

confidence: 84%

“…Compared to other studies, similar T2-values of the IVDs were retrieved [14,16,19]. Histogram analysis of IVDs of different Pfirrmann grades generated a wide and continuous range of Dl which shows that histogram analysis might be a suitable tool to be used for objective and continuous IVD degeneration classification.…”

Section: Discussionmentioning

confidence: 56%

MRI histogram analysis enables objective and continuous classification of intervertebral disc degeneration

et al. 2017

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“…The most common method in the literature with regard to T1 and T2 is to acquire small regions of interest that are anatomically based. [6][7][8][9] Authors have used standard ROIs, delineating subregions within the intervertebral disk to extract quantitative data specifically from the NP and AF. 6,7 Additional intermediate ROIs on boundaries between the nucleus and annulus have also been used.…”

mentioning

confidence: 99%

T1ρ and T2 Mapping of the Intervertebral Disk: Comparison of Different Methods of Segmentation

Reis¹,

Salmon

Carvalho³

et al. 2014

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Intervertebral disk biochemical composition could be accessed in vivo by T1 and T2 relaxometry. We found no studies in the literature comparing different segmentation methods for data extraction using these techniques. Our aim was to compare different manual segmentation methods used to extract T1 and T2 relaxation times of intervertebral disks from MR imaging. Seven different methods of partial-disk segmentation techniques were compared with whole-disk segmentation as the reference standard.

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“…We consider our method more reliably reproducible than the visual manual selection of ROIs used in previous reports for minimizing measurement bias. 13,15,16 In the IVD, we observed a significant decrease in T 2 values in the DS group for only the anterior AF, which indicated greater degeneration in the DS group. We observed no significant changes in T 2 values in either group for the posterior AF and NP.…”

Section: Discussionmentioning

confidence: 70%

“…11,13 Previous studies have reported decreased T 2 values of the NP with disc degeneration. [13][14][15] Others have reported decreased or increased T 2 values of the AF with degeneration without consensus. 14,16 In addition, the association of T 2 values with FJ and degeneration has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Intervertebral Disc and Facet Joint in Lumbar Spondylolisthesis using T2 Mapping

et al. 2014

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Purpose: We measured T 2 relaxation time of the intervertebral discs (IVD) and facet joints (FJ) in patients with degenerative spondylolisthesis (DS) and no spondylolisthesis (NS) and investigated the characteristics of these parts in DS.Methods: In 40 patients with DS and 40 patients with NS, we measured T 2 relaxation time of the IVD and FJ and compared them between groups. In the group with DS, we also examined the relationship between the degree of slippage using Meyerding grade and T 2 relaxation of each part in the IVD and FJ.Results: T 2 relaxation time of the IVD tended to be lower in the DS than NS group and differed significantly (P < 0.01) within the anterior annulus fibrosus. T 2 relaxation time in the FJ was significantly higher in the DS than NS group. T 2 relaxation time in the FJ was significantly higher for those assessed Meyerding Grade II than Grade I, although we observed no significant differences in T 2 relaxation time in any area of the IVD.Conclusion: T 2 relaxation time decreased in the anterior annulus fibrosus of the IVD and increased in the FJ in patients with DS, suggesting an association of IVD and FJ degeneration with the development of lumbar DS.

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T2 Relaxation Times Correlated with Stage of Lumbar Intervertebral Disk Degeneration and Patient Age

Abstract: BACKGROUND AND PURPOSE: T2 relaxation times provide a continuous measure of changes in intervertebral disk biochemistry. The purpose of this study was to correlate T2 relaxation times in lumbar disks with patient age and stage of degeneration.

Cited by 94 publications

References 21 publications

MRI histogram analysis enables objective and continuous classification of intervertebral disc degeneration

MRI histogram analysis enables objective and continuous classification of intervertebral disc degeneration

T1ρ and T2 Mapping of the Intervertebral Disk: Comparison of Different Methods of Segmentation

Investigation of Intervertebral Disc and Facet Joint in Lumbar Spondylolisthesis using T2 Mapping

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