T2*-weighted MRI as a non-contrast-enhanced method for assessment of focal laser ablation zone extent in prostate cancer thermotherapy

Sun, Chongpeng; Wang, Shiyang; Chatterjee, Aritrick; Medved, Milica; Eggener, Scott E.; Karczmar, Gregory S.; Oto, Aytekin

doi:10.1007/s00330-020-07127-7

Eur Radiol

2020

DOI: 10.1007/s00330-020-07127-7

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T2*-weighted MRI as a non-contrast-enhanced method for assessment of focal laser ablation zone extent in prostate cancer thermotherapy

Chongpeng Sun

Shiyang Wang

Aritrick Chatterjee

et al.

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Cited by 3 publications

(3 citation statements)

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“…20 In addition, the application of T2* in the evaluation of prostate cancer has been validated. 24,25 PI-RADS v2.1 considers T2WI as the most important sequence for detection and characterization of TZ lesions, followed by DWI. 26,27 In theory, the apparent diffusion coefficient (ADC) and quantitative T2* provide important biophysical information that is related to TZ PCa.…”

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confidence: 99%

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Amide Proton Transfer Could Provide More Accurate Lesion Characterization in the Transition Zone of the Prostate

Guo

Qin

et al. 2022

Magnetic Resonance Imaging

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Background There is an overlap comparing transition zone prostate cancer (TZ PCa) and benign prostatic hyperplasia (BPH) on T2‐weighted imaging (T2WI) and diffusion‐weighted imaging (DWI), creating additional challenges for assessment of TZ tumors on MRI. Purpose To evaluate whether amide proton transfer‐weighted (APTw) imaging provides new diagnostic ideas for TZ PCa. Study type Prospective. Population A total of 51 TZ PCa patients (age, 49–89), 44 stromal BPH (age, 57–92), and 45 glandular BPH patients (age, 56–92). Field Strength/Sequence A 3 T; T2WI turbo spin echo (TSE), quantitative T2*‐weighted imaging, DWI echo planar imaging, 3D APTw TSE. Assessment Differences in APTw, apparent diffusion coefficient (ADC), and T2* among three lesions were compared by one‐way analysis of variance (ANOVA). Regions of interest were drawn by two radiologists (X.Q.Z. and X.Y.Q., with 21 and 15 years of experience, respectively). Statistical Tests Multivariable logistic regression analyses; ANOVA with post hoc testing; receiver operator characteristic curve analysis; Delong test. Significance level: P < 0.05. Results APTw among TZ PCa, stromal BPH, and glandular BPH (3.48% ± 0.83% vs. 2.76% ± 0.49% vs. 2.72% ± 0.45%, respectively) were significantly different except between stromal BPH and glandular BPH (P > 0.99). Significant differences were found in ADC (TZ PCa 0.76 ± 0.16 × 10−3 mm2/sec vs. stromal BPH 0.91 ± 0.14 × 10−3 mm2/sec vs. glandular BPH 1.08 ± 0.18 × 10−3 mm2/sec) among three lesions. APTw (OR = 12.18, 11.80, respectively) and 1/ADC (OR = 703.87, 181.11, respectively) were independent predictors of TZ PCa from BPH and stromal BPH. The combination of APTw and ADC had better diagnostic performance in the identification of TZ PCa from BPH and stromal BPH. Data Conclusion APTw imaging has the potential to be of added value to ADC in differentiating TZ PCa from BPH and stromal BPH. Evidence Level 2 Technical Efficacy Stage 2

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confidence: 99%

“…APTw values had been reported to have the potential to be imaging predictors and biomarkers of disease 20 . In addition, the application of T2* in the evaluation of prostate cancer has been validated 24,25 …”

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confidence: 99%

Amide Proton Transfer Could Provide More Accurate Lesion Characterization in the Transition Zone of the Prostate

Guo

Qin

et al. 2022

Magnetic Resonance Imaging

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“…For confirmation of the ablation zone, a contrast-enhanced T1W scan is usually done (with optional subtraction images) at the end of treatment. Re-treatment after gadolinium contrast administration is not performed, as the contrast agents can be retained in the ablated tissue for several hours [26]. This makes the evaluation after re-treatment suboptimal, and causes potential toxicity if the stability of the gadolinium chelate is compromised by markedly increased tissue temperatures.…”

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confidence: 99%

Real-Time MRI-Guided Prostate Interventions

Masoom

Sundaram

Ghanouni

et al. 2022

Cancers

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Prostate cancer (PCa) is the second most common cause of cancer death in males. Targeting MRI-visible lesions has led to an overall increase in the detection of clinically significant PCa compared to the prior practice of random ultrasound-guided biopsy of the prostate. Additionally, advances in MRI-guided minimally invasive focal treatments are providing new options for patients with PCa. This review summarizes the currently utilized real-time MRI-guided interventions for PCa diagnosis and treatment.

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Klinischer Stellenwert kontrastmittelfreier Kurzprotokolle in der Magnetresonanztomographie

Solyanik

Heimer

2021

Radiologe

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T2*-weighted MRI as a non-contrast-enhanced method for assessment of focal laser ablation zone extent in prostate cancer thermotherapy

Cited by 3 publications

References 33 publications

Amide Proton Transfer Could Provide More Accurate Lesion Characterization in the Transition Zone of the Prostate

Amide Proton Transfer Could Provide More Accurate Lesion Characterization in the Transition Zone of the Prostate

Real-Time MRI-Guided Prostate Interventions

Klinischer Stellenwert kontrastmittelfreier Kurzprotokolle in der Magnetresonanztomographie

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