T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients

Rubattu, Speranza; Giusti, M; Farcomeni, Alessio; Abbolito, Sofia; Comito, Filomena; Cangianiello, Sara; Greco, Ettore S.; Dito, Eleonora; Pagliaro, Beniamino; Cotugno, Maria; Stanzione, Rosita; Marchitti, Simona; Bianchi, Francesca; Castro, Sara Di; Battistoni, Allegra; Burocchi, Simone; Caprinozzi, Massimo; Pierelli, Giorgia; Sciarretta, Sebastiano; Volpe, Massimo

doi:10.2459/jcm.0000000000000195

Cited by 10 publications

(8 citation statements)

References 28 publications

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“…A previous study performed by a research group from our university showed that the A2A2 allele is associated with a higher incidence of histories of non-fatal myocardial infarction and more extensive CAD [ 20 ]. More recently Rubattu et al demonstrated that ANP polymorphism is associated with higher risk for an acute coronary syndrome recurrence in patients with CAD [ 21 ]. Moreover, a recently published meta-analysis indicated that ANP 2238 T/C polymorphism is related to increased risk of ischaemic stroke [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Scal atrial natriuretic peptide gene polymorphisms and their possible association with postoperative atrial fibrillation – a preliminary report

Siebert¹,

Lewicki²,

Myśliwska³

et al. 2017

aoms

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IntroductionAtrial fibrillation (AF) is a frequently encountered complication after coronary artery bypass grafting (CABG), but its underlying mechanisms are still unclear. The natriuretic peptides have been reported as markers for predicting the occurrence of postoperative AF. This study evaluates whether the ScaI ANP gene polymorphisms predict the occurrence of postoperative AF.Material and methodsA prospective study of 203 consecutive patients with coronary artery disease undergoing elective CABG was undertaken for atrial natriuretic peptide (ANP) ScaI gene polymorphism. Several perioperative data were analysed. Postoperative AF was defined as lasting for at least 15 min, confirmed by 12-lead ECG and occurring within 6 postoperative days. The ScaI polymorphism of the ANP gene was determined by polymerase chain reaction (PCR). Size-dependent separation of the PCR products on a polyacrylamide gel was followed by staining with ethidium bromide.ResultsThe total frequency of AF was 19.7%. The frequencies of ScaI ANP gene polymorphisms were as follows: A1A1 4.90%, A1A2 59.60% and A2A2 35.46%. In order to assess the hypothesis that the A2 allele is a marker of increased risk of postoperative atrial fibrillation, the odds ratio (OR) was calculated: A2 vs. non-A2, OR = 0.98 (0.23–4.1), p = 0.97, which was not significant. The odds ratios for A2A2 and A1A1 were not significant either: A2A2 vs. non-A2A2, OR = 1.11 (0.54–2.29), p = 0.76, and A1A1 vs. non-A1A1, OR = 1.17 (0.23–5.92), p = 0.84.ConclusionsANP genotype did not predispose to the incidence of “new-onset” AF.

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Section: Discussionmentioning

confidence: 99%

Scal atrial natriuretic peptide gene polymorphisms and their possible association with postoperative atrial fibrillation – a preliminary report

Siebert¹,

Lewicki²,

Myśliwska³

et al. 2017

aoms

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“…Furthermore, the markers that are associated with reACS have also been identified in recent years. Rubattu et al showed that the 2238C ANP gene variant is associated with recurrent ACS (7). Kume N et al determined that lectin-like oxidized low density lipoprotein receptor-1 (LOX -1) in circulation predicted recurrent ACS and mortality (8).…”

Section: Discussionmentioning

confidence: 99%

“…Many clinical and laboratory parameters associated with mortality in patients with CAD were studied (5,6). However, affordable and easily accessible biomarker-based studies that are related to re-ACS are still scarce (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Red cell distribution width (RDW) and increased risk of recurrent acute coronary syndrome

2015

Acta Med Anatol

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Objectives: Red cell distribution width (RDW) is associated with mortality in cardiopulmonary disorders such as coronary artery disease (CAD), acute coronary syndrome (ACS), heart failure, and acute pulmonary embolism. However, the little data that is available show the relationship between RDW and re-ACS after discharge in ACS patients. We aimed to investigate for relation between admission RDW and reACS related rehospitalization in ACS patients. Methods: A total of 400 consecutive patients with ACS were evaluated. In ROC curve analysis: optimal cutoff value of RDW to predict re-ACS was found as >14.0%, with 70% sensitivity and 62.5% specificity. Patients were categorized as having no increased (Group I) or increased (Group II) RDW based on a cut off value of 14.0%. Results: Mean age of patients was 63±12 years. Mean follow-up duration was 15±9 months and 80 patients rehospitalized with reACS. Among these 80 patients 24 (11%) patients belonged to Group I, and 56 (32%) patients were in Group II (p<0.001). Increased RDW > 14.0% on admission, presence of ST elevation MI, LV ejection fraction, and HDL cholesterol levels were found to have prognostic significance in univariate analysis. In multivariate Cox proportional-hazards model, only increased RDW > 14.0% on admission (HF=2.355, P=0.002), and previous ST elevation MI (HR: 1.906, P=0.024) remained associated with an increased risk of re-ACS. Furthermore, the mortality rate of the patients in the second group were significantly higher than those observed in the first group (4 (2%) vs 27 (15%), p<0.001). Conclusions: It seems RDW helps risk stratification in patients with ACS.

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“…Several case-control association studies were performed in the attempt to explore the pathological relevance of the T2238C transition. As a result, an association of the C2238 allele with an increased risk of both myocardial infarction and stroke was reported in different cohorts, including Caucasian and Asian populations [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Moreover, carriers of this variant allele showed an increased risk of recurrent ischemic stroke and of myocardial infarction [ 16 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

The T2238C Human Atrial Natriuretic Peptide Molecular Variant and the Risk of Cardiovascular Diseases

Rubattu

Sciarretta

Marchitti

et al. 2018

IJMS

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Atrial natriuretic peptide (ANP) is a cardiac hormone which plays important functions to maintain cardio-renal homeostasis. The peptide structure is highly conserved among species. However, a few gene variants are known to fall within the human ANP gene. The variant rs5065 (T2238C) exerts the most substantial effects. The T to C transition at the 2238 position of the gene (13–23% allele frequency in the general population) leads to the production of a 30-, instead of 28-, amino-acid-long α-carboxy-terminal peptide. In vitro, CC2238/αANP increases the levels of reactive oxygen species and causes endothelial damage, vascular smooth muscle cells contraction, and increased platelet aggregation. These effects are achieved through the deregulated activation of type C natriuretic peptide receptor, the consequent inhibition of adenylate cyclase activity, and the activation of Giα proteins. In vivo, endothelial dysfunction and increased platelet aggregation are present in human subjects carrying the C2238/αANP allele variant. Several studies documented an increased risk of stroke and of myocardial infarction in C2238/αANP carriers. Recently, an incomplete response to antiplatelet therapy in ischemic heart disease patients carrying the C2238/αANP variant and undergoing percutaneous coronary revascularization has been reported. In summary, the overall evidence supports the concept that T2238C/ANP is a cardiovascular genetic risk factor that needs to be taken into account in daily clinical practice.

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T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients

Cited by 10 publications

References 28 publications

Scal atrial natriuretic peptide gene polymorphisms and their possible association with postoperative atrial fibrillation – a preliminary report

Scal atrial natriuretic peptide gene polymorphisms and their possible association with postoperative atrial fibrillation – a preliminary report

Red cell distribution width (RDW) and increased risk of recurrent acute coronary syndrome

The T2238C Human Atrial Natriuretic Peptide Molecular Variant and the Risk of Cardiovascular Diseases

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