T3P catalyzed one pot three-component synthesis of 2,3-disubstituted 3H-quinazolin-4-ones

Practical approach to 2-thioxo-2,3-dihydroquinazolin-4(1 H )-one via dithiocarbamate–anthranilic acid reaction

“…However the difficult handling of unstable isothiocyanate as well as preparation of costly and toxic reagents, such as thiophosgene limits its practical applications. On the other hand, the dithiocarbamates are safe and highly efficient equivalent to isothiocyanate and were found to show broad application owing to their easy preparation in large scale from simple and readily available starting material [28][29][30][31][32][33][34]. In this context, our interest in green synthesis of dithiocarbamate derivatives [35,36], we aimed to develop an efficient and facile approach to synthesize a series of thioxoquinazolin-4(1H)-ones from dithiocarbamate derivatives under the mild and safe conditions.…”

Palladium-Catalyzed Synthesis of Aldehydes from Aryl Iodides and Formic acid with Propylphosphonic Anhydride as the Activator

“…High yields of the corresponding aldehydes were produced. During our studies on carbonylation reactions, propylphosphonic anhydride comes into our view 20 – 24 . Propylphosphonic anhydride has been applied in carboxylic acids activation, and we believe it can activate formic acid to release CO as well.…”

Microwave-Assisted, Metal-Free, Chemoselective N-Formylation of Amines using 2-Formyl-1,3-dimethyl-1H-imidazol-3-ium Iodide and In Situ Synthesis of Benzimidazole and Isocyanides

“…[28][29][30] However, many of these methods have limitations such as long reaction times, harsh reaction conditions, low yields, expensive reagents, lack of selectivity or generality, and decrease in turnover number of the catalyst. In continuation of our research in the area of development of novel methods for the synthesis of amides, 31 o-uredobenzonitriles, 32 bioactive heterocyclic small molecules, 33 and synthetic applications of T3P [34][35][36][37][38][39] and dithioesters, 40 we have developed a microwave-assisted N-formylation protocol for…”