T4 ERK5 degradation: a turning point from compensated metabolic cardiomyopathy to heart failure

Shenqi Lixin Decoction improves cardiac function in rats with adriamycin-induced heart failure through modulation of PGC-1α and mitochondrial apoptosis pathway

“…PGC-1α is a key regulator that promotes mitochondrial biosynthesis, enhances respiratory function and energy metabolism, and plays an important role in various energy metabolism processes of the body (14). PGC-1α participates in regulating the physiological functions of myocardial mitochondria by regulating the coupled respiration of myocardial mitochondria, promoting the production of myocardial ATP, and then regulating the contractile function of the heart (15). The expression of PGC-1α in myocardial tissue is abundant.…”