T47D cell-inhibiting indonesian medicinal plants and active constituents of Alpinia galanga rhizome

Da'i, Muhammad; Fadhilah, Arini; Rahmawati, Juwita; Forentin, Alfian Mahardika; Usia, Tepy; Maryati, Maryati; Saifudin, Azis

doi:10.4103/pm.pm_259_17

Cited by 2 publications

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“…at a concentration of 25 μg/mL and incubated for 24 h, revealed a significant inhibitory activity against the T47D breast cancer cell line, with inhibition percentages of 96.4%, 87.6%, 82.6%, and 88.7%, respectively. Epirubicin and doxorubicin were used as positive control, and DMSO for negative control ( Dai et al, 2018 ). The cytotoxic activities of the V. trifolia aerial parts were evaluated in an in vivo study using three different extracts: methanol, ethyl acetate, and chloroform.…”

Section: Biological Activities Of V Trifoliamentioning

confidence: 99%

A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

Mottaghipisheh,

Kamali,

Doustimotlagh

et al. 2024

Front. Pharmacol.

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Plants, renowned for their rich reservoir of metabolites, play a pivotal role in addressing health-related issues. The Verbenaceae family stands out, showcasing immense potential in preventing and treating chronic diseases. Vitex trifolia L. (V. trifolia), a shrub with a rich history in traditional medicine, particularly in Eastern Asia, has garnered attention for its diverse therapeutic applications. This comprehensive review aims to bridge traditional knowledge and contemporary insights by investigating ethnopharmacology, phytochemistry, and pharmacological effects of V. trifolia. The keyword “V. trifolia” and its synonyms were searched within the main scientific databases including PubMed, Web of Science, ScienceDirect, Google Scholar, and Baidu Scholar (from 1974 to 2022, last search: 21.10.2023). Phytochemical analyses reveal a spectrum of secondary metabolites in V. trifolia, including terpenoids, flavonoids, lignans, phytosterols, anthraquinones, and fatty acids. Notably, terpenoids and flavonoids emerge as the main bioactive metabolites. Pharmacological studies validate its therapeutic potential, demonstrating significant antioxidant, anti-inflammatory, hepatoprotective, anticancer, anti-amnesic, antimicrobial, antiviral, anti-malaria, antispasmodic activities, and reported insecticidal effects. Despite existing literature exploring pharmacological attributes and secondary metabolites of related species, a conspicuous gap exists, specifically focusing on the pharmacological activities and novel methods of purification of pure metabolites from V. trifolia. This review aimed to fill this gap by delving into traditional medicinal applications, exploring secondary metabolites comprehensively, and providing an in-depth analysis of pharmacological effects of pure metabolites. Combining traditional uses with contemporary pharmacological insights, this article sought to serve as a crucial reference for future research and practical application of V. trifolia. This approach contributes substantially to understanding the plant, fostering scientific inquiry, and facilitating its broader application in healthcare.

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Section: Biological Activities Of V Trifoliamentioning

confidence: 99%

A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

Mottaghipisheh,

Kamali,

Doustimotlagh

et al. 2024

Front. Pharmacol.

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Analytical Method Development for Authentication of Alpinia galanga Rhizome Based on Phenylpropanoid Markers by RP-HPLC-UV

Saifudin,

Yuni Astuti,

Nur Hidayati

et al. 2024

RJPT

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Current reports have revealed that Alpinia galanga rhizome is among the most promising medicinal plants for possible cancer treatments. Their active markers have been proposed as phenylpropanoid group derivatives. The geographical origins may result in the chemical constituent diversity that might affect A. galanga bioactivity. A rapid and economic HPLC-UV method has been developed to allow the analysis of four chemical markers, namely trans-p-coumaryl alcohol (1), p-coumaryl diacetate (2), [1’S]-1’-acetoxy chavicol (3), and trans-p-coumaryl diacetate (4). Separation was achieved on the C-18 column using a methanol-water solvent system without any modifiers. The samples were collected from twelve cultivation centers of A. galanga in Indonesia: Karangpandan, Karanganyar Solo, Wonogiri, Klaten, Selogiri, Boyolali, Jogja, Kudus, Singkawang, Banjarmasin, and Lampung. Their chemical profiles were examined based of HPLC-UV technique. The chromatography system was able to reveal all of the markers. Interestingly, all of the samples displayed significant T47D breast cancer cell inhibitory activity with apparent IC50 values of 27 to 65 µg/mL. The presence of 1 or 2 in a high concentration did not significantly contribute to the inhibitory effect, but the presence of 3 and 4 in a certain percentage might maintain the activity. Furthermore, on the basis of principal component analysis (PCA), A. galanga samples collected from different geographical origins could be featured. This efficient HPLC-based technique possesses a good prospect of being applied for industrial purposes.

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T47D cell-inhibiting indonesian medicinal plants and active constituents of Alpinia galanga rhizome

Cited by 2 publications

References 0 publications

A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.

Analytical Method Development for Authentication of Alpinia galanga Rhizome Based on Phenylpropanoid Markers by RP-HPLC-UV

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