Studies have shown that algae and seaweed have cytotoxic activity. This study was aimed to determine the cytotoxic activity of Spirulina platensis and Ulva compressa Linn. extracts against cancer cell lines. The cytotoxic activity of the extract was carried out using the MTT ((3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. Results showed that the ethanol extract and methanol extract of Spirulina platensis have no cytotoxic effect against HeLa, WiDr, MCF7 and T47D cells. Water extract of Spirulina platensis had no cytotoxic activity on T47D and Vero cells. Water extracts of Spirulina platensis increase MCF7 cell growth. Phycocyanin powder also stimulates MCF7 cell growth. Ethanol extract of Ulva compressa Linn. exhibited potentially cytotoxic activity against MCF7 and moderate cytotoxic against WiDR cells with IC50 values are 31.86 μg/ mL and 104.93 μg/mL, respectively. It can be concluded that extract of Spirulina platensis has no potential to be developed for cancer therapy. Ulva compressa Linn has the potential to be developed as an anti-cancer. Further research for study the mechanism of anticancer of Ulva compressa Linn on MCF7 was needed.
Avocado plants are widely used as traditional medicine in Indonesia. This research aimed to determine the cytotoxic and antiproliferation activity of avocado seed extract and fractions on the T47D breast cancer cell line. Extraction was done by maceration method using 96% ethanol, then fractionation was done by liquid-liquid partition using n-hexane, chloroform, and ethyl acetate. Cytotoxic and antiproliferation tests were done by the MTT method. Apoptosis activity was investigated by the double staining method, using acridine orange-propidium iodide as a staining reagent. Results showed that the n-hexane fraction of avocado seed had a cytotoxic activity with IC50 27.9 µg/mL. N-hexane fraction of avocado seed inhibited proliferation and induced apoptosis of T47D cell line.
This descriptive research investigated the influence of the flap poster on students' creativity in studying human respiratory system. Samples were 34 eight grade students in one of Private International Schools in Bogor, in which they were divided into experimental or control class, 17 students for each class. Qualitative data were obtained by using rubric and questionnaire. Results showed that experimental class students' creativity was higher than control class students, in which this indicates that flap poster can facilitate students in developing their creativity. Furthermore, results also indicated that when the flap poster was implemented in learning Human Respiratory concept, experimental class achieved better results in every creativity dimension compared to control class.Kata kunci: flap poster, creativity, human respiratory system ABSTRAK Penelitian deskriptif ini menyelidiki pengaruh penggunaan flap poster terhadap kreativitas siswa dalam mempelajari materi Sistem Pernapasan Manusia. Sampel adalah 34 siswa kelas delapan di salah satu sekolah swasta internasional yang ada di Bogor. Siswa kemudian dibagi menjadi kelompok eksperimen dan kontrol dengan 17 siswa untuk masing-masing kelas. Data kualitatif diperoleh dengan menggunakan rubrik dan kuesioner. Hasil menunjukkan bahwa siswa di kelas eksperimen memiliki kreativitas yang lebih tinggi dibandingkan dengan kelas kontrol, dan ini mengindikasikan bahwa flap poster dapat memfasilitasi siswa dalam mengembangkan kreativitasnya. Selain itu, hasil juga mengindikasikan bahwa ketika flap foster diimplementasikan dalam mempelajari konsep Pernapasan Manusia, kelas eksperimen meraih hasil yang lebih baik dalam semua dimensi kreativitas dibandingkan dengan kelas kontrol.
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